Core: Biorepository and Clinical Trial Office Shared Resource

核心：生物样本库和临床试验办公室共享资源

• 批准号: 10911638
• 负责人: Gnana Sakuntala Warshamana-Greene
• 金额: $ 3.06万
• 依托单位: SOUTH CAROLINA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10911638
• 关键词: Academic Medical Centers; Address; African ancestry; Biological; Black Populations; Blood; Breast Cancer Patient; Cancer Center; Caring; Clinical; Clinical Research; Clinical Trials; Communities; Data; Development; Enrollment; Ethnic Origin; Faculty; Funding; Future; Goals; Health Services Research; Infrastructure; Leadership; Malignant Neoplasms; Malignant neoplasm of prostate; Medical center; Minority; Morbidity - disease rate; Outcome; Patients; Population Heterogeneity; Provider; Quality of life; Research; Research Personnel; Research Project Grants; Resource Sharing; South Carolina; Specimen; Survivors; Tissues; Universities; anticancer research; biobank; cancer care; cancer health disparity; care delivery; clinical center; clinical trial implementation; community setting; ethnic diversity; implementation facilitation; improved; mortality; outcome disparities; patient oriented; patient population; racial diversity; racial minority; research study; rural area

BIOREPOSITORY AND CLINICAL TRIALS OFFICE SHARED RESOURCE SUMMARY The establishment and implementation of the South Carolina Cancer Disparities Research Center (SC CADRE) Biorepository/Clinical Trials Office (CTO) Shared Resource is expected to significantly expand the research capacity of the SC CADRE investigators at South Carolina State University (SCSU), thus enhancing their ability to compete for independent, R01-level funding. This new, dual-component Shared Resource will also augment SCSU's ability to attract additional junior faculty researchers who will have access to biospecimens from racially and ethnically diverse patient populations as well as to clinical trials infrastructure at the Regional Medical Center of Orangeburg Mabry Cancer Center (RMC-MCC). The overarching goal of the Biorepository/CTO Shared Resource is to support the development of cancer research at SCSU through both a Biorepository component and a CTO component. The Biorepository component will give SC CADRE investigators access to the RMC-MCC's patient blood and tissue specimens that were previously unavailable for research due to the lack of a biorepository infrastructure. Likewise, the CTO component will facilitate the implementation of clinical trials, providing an infrastructure for SCSU investigators to conduct research in their Orangeburg, SC community as well as providing the Orangeburg community immediate access to other NCI- approved clinical trials which have not been available to date. This Shared Resource will support the implementation of two initial SC CADRE clinical trials in Years 1-3 which will provide the biological and outcomes data needed to evaluate the hypothesized relationships that are being assessed in each of the three initial SC CADRE Full and Pilot Research Projects. Additionally, this Biorepository/CTO Shared Resource will support future SC CADRE Full and Pilot Research Projects as well as other NCI-approved clinical research studies at the RMC-MCC, with the goal of enhancing participation of diverse populations in cancer clinical research.

生物样本库和临床试验办公室共享资源 概括 南卡罗来纳州癌症差异研究中心（SC CADRE）生物样本库/临床试验办公室（CTO）共享资源预计将显着扩展 南卡罗来纳州立大学 (SCSU) 的 SC CADRE 研究人员的研究能力，从而增强 他们有能力竞争独立的 R01 级资金。这个新的双组件共享资源将 还增强了 SCSU 吸引更多初级教师研究人员的能力，他们将有机会获得 来自不同种族和民族的患者群体的生物样本以及临床试验基础设施 奥兰治堡马布里癌症中心区域医疗中心 (RMC-MCC)。该组织的总体目标是 生物库/CTO 共享资源旨在通过以下方式支持 SCSU 癌症研究的发展 一个 Biorepository 组件和一个 CTO 组件。生物储存库组件将提供 SC CADRE 研究人员可以获取以前无法获得的 RMC-MCC 患者血液和组织样本 由于缺乏生物样本库基础设施而无法进行研究。同样，CTO 组件将促进 实施临床试验，为 SCSU 研究人员进行研究提供基础设施 奥兰治堡, SC 社区以及为奥兰治堡社区提供直接访问其他 NCI- 迄今为止尚未获得批准的临床试验。该共享资源将支持 在第 1-3 年实施两项初步 SC CADRE 临床试验，这将提供生物学和 评估三者中每一个中正在评估的假设关系所需的结果数据 初始 SC CADRE 全面和试点研究项目。此外，该 Biorepository/CTO 共享资源将 支持未来的 SC CADRE 全面和试点研究项目以及其他 NCI 批准的临床研究 RMC-MCC 的研究，旨在加强不同人群对癌症临床的参与 研究。