Investigating the impact of physical activity in modulating PCOS risk among peripubertal females

调查体力活动对调节青春期前后女性 PCOS 风险的影响

基本信息

批准号：
10591971
负责人：
Rachel Whooten
金额：
$ 19.42万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-01 至 2027-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10591971
关键词：
Adolescence Adolescent Adult Advisory Committees Affect Age Androgens Area Attenuated Behavior Behavior Therapy Behavioral Biometry Cardiovascular Diseases Caregivers Childhood Chronic Disease Clinical Clinical Trials Design Collection Communities Complex Data Development Diabetes Mellitus Dissemination and Implementation Endocrine Endocrine Physiology Endocrinologist Enrollment Epidemiology Female Female Adolescents Focus Groups Functional disorder Goals Health Health Care Costs Health Services Health behavior Hormones Hyperandrogenemia Infertility Insulin Insulin Resistance Intervention Irregular Menstruation K-Series Research Career Programs Knowledge Lead Life Cycle Stages Literature Longitudinal cohort Measurement Measures Mental Depression Mentored Patient-Oriented Research Career Development Award Mentorship Metabolic Metabolic Diseases Methods Morbidity - disease rate National Institute of Diabetes and Digestive and Kidney Diseases Natural History Obesity Outcome Phenotype Physical activity Physiological Polycystic Ovary Syndrome Prevention Prevention strategy Primary Prevention Process Public Health Randomized Reproductive Health Research Research Personnel Research Priority Risk Series Strenuous Exercise Structure Target Populations Teenagers Time Training Treatment Efficacy Woman Work actigraphy career cohort comorbidity critical period design disorder prevention early adolescence effective intervention efficacy trial evidence base exercise intervention feasibility testing follow-up girls implementation intervention implementation science improved insight insulin sensitivity intervention participants longitudinal analysis metabolomics multidisciplinary obesity prevention pilot trial preventive intervention reproductive skills therapy design tool young woman

项目摘要

PROJECT ABSTRACT Polycystic Ovary Syndrome (PCOS) affects 1 out of 10 women worldwide. While PCOS is primarily characterized by menstrual irregularity and hyperandrogenemia, it is also associated with multiple comorbidities – including diabetes, cardiovascular disease, depression, and infertility – that lead to substantial morbidity and health care costs. A complex interaction between adiposity, decreased insulin sensitivity, and increased androgen concentrations underlies the pathophysiology of PCOS. These signs often first appear in early adolescence, representing a key opportunity for preventive interventions. While physical activity is a promising strategy for targeting the factors underlying PCOS development, there is a significant literature gap regarding effective strategies for use in PCOS prevention. The goal of this proposal is to identify the time course of changes in insulin dynamics and androgen concentrations in females from mid-childhood through adolescence and the impact of physical activity during early adolescence on these endpoints (Aim 1) and use implementation science methods to refine (Aim 2) and pilot a targeted and evidence-based physical activity intervention in peripubertal girls ages 8-10 at risk for PCOS while assessing the interventions’ feasibility, acceptability, and preliminary efficacy in relation to physical activity levels, insulin sensitivity, and androgen concentrations (Aim 3). The findings from this study will inform the development, dissemination, and implementation of effective and scalable preventive interventions, a high priority area for the NIDDK. Additionally, by specifically targeting young females at risk for later metabolic disease, this proposal takes a life-course approach to chronic disease prevention. The PI, Dr. Whooten, is an early career clinician investigator and pediatric endocrinologist, as well as health services researcher. She will use this career development award to build her skills in (1) the longitudinal analysis of epidemiological cohorts, (2) design and implementation of behavioral interventions informed by an implementation science approach, and (3) collection and measurement of objective behavioral and physiologic outcomes which will be essential for evaluating intervention efficacy. Dr. Whooten will work closely with a multidisciplinary mentorship and advisory team with expertise in epidemiology, objective measurement of health behaviors, measurement of endocrine physiologic outcomes, implementation science, and biostatistics to carry out her stated career objectives and specific aims.

项目摘要多囊卵巢综合症 (PCOS) 影响着全球十分之一的女性。主要特征是月经不规律和高雄激素血症，它也与患有多种合并症——包括糖尿病、心血管疾病、抑郁症和不孕不育——导致大量的发病率和医疗保健费用。肥胖、胰岛素敏感性降低和雄激素浓度升高之间的关系这些症状通常首先出现在青春期早期，身体活动是预防性干预的一个重要机会。针对 PCOS 发展的潜在因素的策略，有大量文献在预防 PCOS 的有效策略方面存在差距该提案的目标是：确定女性胰岛素动态和雄激素浓度变化的时间过程从童年中期到青春期以及早期身体活动的影响青少年期关注这些终点（目标 1），并使用实施科学方法来完善（目标 2）并在青春期周围试点有针对性的、基于证据的体力活动干预 8-10 岁有 PCOS 风险的女孩，同时评估干预措施的可行性、可接受性和与体力活动水平、胰岛素敏感性和雄激素相关的初步疗效浓度（目标 3）。本研究的结果将为开发、传播、以及实施有效和可扩展的预防性干预措施，这是此外，NIDDK 专门针对有罹患代谢性疾病风险的年轻女性，该提案采用生命全程方法来预防慢性疾病。是一名早期职业临床医生调查员和儿科内分泌学家，以及健康服务她将利用这个职业发展奖来培养她在 (1) 纵向方面的技能。流行病学队列分析，（2）行为干预措施的设计和实施通过实施科学方法提供信息，以及 (3) 收集和测量行为目标和生理结果对于评估干预至关重要 Whooten 博士将与多学科指导和咨询团队密切合作。具有流行病学、客观测量健康行为、测量内分泌生理结果、实施科学和生物统计学来开展她的研究明确的职业目标和具体目标。