Pathways to enrolling diverse Latinos in autopsy studies: Insights from a largelongitudinal study

让不同拉丁裔参加尸检研究的途径：大型纵向研究的见解

基本信息

批准号：
10592154
负责人：
Alejandra Morlett Paredes
金额：
$ 11.63万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10592154
关键词：
Age Aging Agreement Altruism Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Area Attitude Autopsy Belief Brain California Chicago Cognitive Communities Complex Consent Data Dementia Development Diagnosis Dimensions Disparity Education Educational Materials Enrollment Ensure Etiology Face Focus Groups Foundations Funding Goals Happiness Health High Prevalence Infrastructure Intention Intervention Investigation K-Series Research Career Programs Knowledge Latino Latino Population Lead Measures Mediating Mentored Research Scientist Development Award Mentors Methods Minority Modeling Neurocognitive Neurosciences Organ Donations Participant Pathology Pathway interactions Perception Persons Pilot Projects Population Populations at Risk Postdoctoral Fellow Procedures Process Productivity Publications Questionnaires Religious Belief Research Research Methodology Research Personnel Research Project Grants Resources Sample Size Scientist Study of Latinos Surveys Techniques Time Training Trust Underserved Population Universities brain tissue career career development cohort community engagement design diagnostic tool education research improved insight instrument neuropathology optimism pilot test post intervention programs recruit skills social culture symposium

项目摘要

PROJECT ABSTRACT This is an application for a K01 award for Dr. Alejandra Morlett Paredes, a postdoctoral fellow in the Neurosciences department at the University of California, San Diego (UCSD). Dr. Morlett Paredes is establishing herself as a young researcher conducting research to further understand Latino’s intentions to consent and participate in brain donation studies and those that include invasive procedures for Alzheimer’s Disease and Related Dementias (ADRD) research. This K01 award will provide Dr. Morlett Paredes with the support and time necessary to accomplish the following goals: (1) gain proficiency in community engagement and recruitment; (2) gain proficiency in mixed methods and survey research methodologies; (3) gain proficiency in neuropathology of dementias; and (4) to develop grantsmanship and professional skills. To achieve these goals, Dr. Morlett Paredes has assembled an expert mentoring team, including her primary mentor: Dr. Hector M. González (expertise in neuroscience) and co-mentoring team: Drs. Lisa Barnes and David X. Marquez (experts in community-based recruitment with underserved populations), Dr. Mark R. Luborsky (expert in mixed methods and survey development) and Dr. Anne Hiniker (expert in Alzheimer’s disease neuropathology and brain autopsy process). The goal of the proposed project is to develop a survey instrument and culturally-tailored educational material that will measure intention to consent and participate in brain donation studies for ADRD research among older and diverse Latinos. Dr. Morlett Paredes will achieve this goal through the following specific aims: Aim 1: (a) Develop and validate a new questionnaire, informed by the Organ Donation Model, to assess dimensions of older Latinos’ intent to participate in brain donation research amongst community based and UCSD ADRC participants; (b) Design culturally-tailored educational information through use of focus group techniques. Implement the new instrument developed in Aim 1a to pilot test the impact of these materials by comparing pre- and post-intervention scores on attitudes and intention to consent and participate in brain donation research using UCSD ADRC participants and older community-based Latinos from the San Diego area. Aim 2: Implement the new survey instrument in a large cohort of diverse older Latinos from the SOL-INCA to obtain information on attitudes and intention to participate in brain donation research. If validated, this study will be used to develop an R01 to enroll diverse Latinos in autopsy studies at ADRCs across the US proximal to 4 SOL-INCA Field Centers in Bronx, Chicago, Miami, and San Diego, beginning with the UCSD ADRC.

项目摘要这是 Alejandra Morlett Paredes 博士的 K01 奖申请，他是该大学的博士后研究员。 Morlett Paredes 博士正在加州大学圣地亚哥分校 (UCSD) 建立神经科学系。她自己作为一名年轻的研究人员进行研究，以进一步了解拉丁裔同意和同意的意图参与大脑捐赠研究以及包括阿尔茨海默病和侵入性手术的研究该 K01 奖项将为 Morlett Paredes 博士提供支持和时间。实现以下目标所必需的：(1) 熟练掌握社区参与和招聘；(2) (3) 熟练掌握神经病理学痴呆症；(4) 发展资助能力和专业技能为了实现这些目标，莫莱特博士。 Paredes 组建了一支专家指导团队，其中包括她的主要导师：Hector M. González 博士（神经科学领域的专家）和共同指导团队：Lisa Barnes 博士和 David X. Marquez 博士（神经科学领域的专家） Mark R. Luborsky 博士（混合方法专家）和调查发展）和 Anne Hiniker 博士（阿尔茨海默病神经病理学和脑尸检专家）过程）。拟议项目的目标是开发一种调查工具和针对文化的教育材料这将衡量老年人 ADRD 研究中同意和参与脑部捐赠研究的意愿 Morlett Paredes 博士将通过以下具体目标实现这一目标：目标 1：(a) 根据器官捐赠模型制定并验证一份新的调查问卷，以评估器官捐赠的维度老年拉丁美洲人有意参与社区和加州大学圣地亚哥分校 ADRC 的大脑捐赠研究参与者； (b) 通过使用焦点小组技术设计适合文化的教育信息。实施目标 1a 中开发的新仪器，通过比较预测试来试点测试这些材料的影响。以及干预后对同意和参与大脑捐赠研究的态度和意愿的评分使用 UCSD ADRC 参与者和来自圣地亚哥地区的老年社区拉丁美洲人目标 2：实施新的调查工具针对来自 SOL-INCA 的一大群不同的老年拉丁美洲人，以获取有关如果得到验证，这项研究将用于制定参与大脑捐赠研究的态度和意图。 R01 旨在招募不同的拉丁裔参加美国各地靠近 4 SOL-INCA Field 的 ADRC 的尸检研究布朗克斯、芝加哥、迈阿密和圣地亚哥的中心，从 UCSD ADRC 开始。