TRANSforma Tu Salud Dejando de Fumar: Advancing smoking cessation among transgender individuals

TRANSforma Tu Salud Dejando de Fumar：促进跨性别者戒烟

• 批准号: 10741034
• 负责人: Ines Aristegui
• 金额: $ 32.5万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-22 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10741034
• 关键词: 2 arm randomized control trial; Abstinence; Address; Adherence; Argentina; Behavior; Behavioral Research; Birth; Clinical Research; Cotinine; Country; Disparity; Effectiveness; Epidemiology; Ferrous fumarate; Fright; Gender Identity; HIV; Health; Healthcare; Image; Income; Individual; Intervention; Interview; Latin American; Latino; Latino Population; Lesbian Gay Bisexual Transgender; Literature; Medical; Mentors; Mexico; Modality; Modification; Multimedia; Participant; Persons; Pharmacy facility; Pilot Projects; Population; Prevalence; Printing; Procedures; Puerto Rico; Randomized; Randomized, Controlled Trials; Reporting; Research; Research Design; Research Personnel; Resources; Smoke; Smoker; Smoking; Smoking Cessation Intervention; Social support; Suicide attempt; Testing; Text; Tobacco; Work; arm; career; community based participatory research; cost; efficacy evaluation; experience; follow up assessment; follow-up; gender affirmation; gender dysphoria; gender expression; health care service; health care settings; housing instability; mHealth; maltreatment; nicotine replacement; pilot test; programs; recruit; satisfaction; sex; smoking abstinence; smoking cessation; social; standard of care; stressor; systematic review; text messaging intervention; transgender; translational study; usability; virtual

PROJECT SUMMARY Mobile health (mHealth) interventions are a promising modality for overcoming barriers and providing culturally appropriate treatment among transgender individuals. mHealth interventions may be appropriate among transgender individuals, as emergent evidence suggests that virtual spaces are used to access gender affirming support and resources. Moreover, mHealth interventions may enable authentic self-expression among transgender individuals, which is not always possible offline. Over the past 7 years, our team has developed Decídetexto, a culturally accommodated smoking cessation text messaging intervention for U.S. Latino smokers. Decídetexto has been expanded to different Latin American countries/regions (e.g., Mexico and Puerto Rico), and has been adapted to different populations (e.g., U.S. Latino smokers living with HIV). A recently completed randomized controlled trial (RCT) with U.S. Latino smokers (n=457) demonstrated that U.S. Latinos receiving the Decídetexto intervention were significantly more likely than those receiving standard of care (smoking cessation printed materials) to be smoking abstinent at Month 6 (34.1% vs 20.6%; p<0.001). Despite the proven effectiveness of Decídetexto among U.S. Latinos, we have identified that this intervention does not adequately address unique barriers to smoking cessation encountered by transgender individuals (e.g., low social support, gender dysphoria as a stressor, need for gender affirming medical procedures). We propose to integrate our expertise in mHealth, smoking cessation, transgender health care, community-based participatory research, and cultural accommodation to develop, pilot test (R21), and then formally evaluate (R33) TRANSformá Tu Salud Dejando de Fumar (Spanish for “TRANSform Your Health by Quitting Smoking”) – a culturally accommodated smoking cessation intervention for transgender individuals. TRANSformá Tu Salud Dejando de Fumar will consist of 1) a 12-week WhatsApp-based program that facilitates longitudinal and bidirectional multimedia-based (i.e., text, image, video, and audio) dialogue with participants, and 2) integration with an e-Pharmacy to access nicotine replacement therapy (NRT) at no cost. R21 Aim 1: Develop TRANSformá Tu Salud Dejando de Fumar, a culturally accommodated smoking cessation intervention for transgender individuals. R21 Aim 2: Assess the feasibility, acceptability, and preliminary impact of TRANSformá Tu Salud Dejando de Fumar among transgender individuals. R33 Aim 1: Assess the efficacy of TRANSformá Tu Salud Dejando de Fumar compared to standard of care on smoking abstinence at Month 6 among transgender individuals. R21-R33 Capacity building. We will build capacity for mHealth behavioral research through the engagement of early career investigators in mentored activities and through academic partnerships between the U.S. and Argentina.

项目概要 移动医疗（mHealth）干预措施是克服障碍和提供文化服务的一种有前途的方式 移动健康干预措施可能适合跨性别者。 跨性别者，因为新的证据表明虚拟空间被用来获得性别肯定 此外，移动医疗干预措施可以实现真实的自我表达。 跨性别者，这在线下并不总是可能的，在过去的 7 年里，我们的团队不断发展。 Decídetext，一种针对美国拉丁裔吸烟者的文化适应戒烟短信干预措施。 Decídetexto 已扩展到不同的拉丁美洲国家/地区（例如墨西哥和波多黎各）， 并已适应不同人群（例如，最近完成的感染艾滋病毒的美国拉丁裔吸烟者）。 针对美国拉丁裔吸烟者 (n=457) 的随机对照试验 (RCT) 表明，美国拉丁裔吸烟者接受 与接受标准护理（吸烟）的患者相比，接受 Decídetext 干预的可能性明显更大 戒烟印刷材料）在第 6 个月戒烟（34.1% vs 20.6%；p<0.001）。 Decídetext 在美国拉丁裔中的有效性，我们发现这种干预措施并没有充分 解决跨性别者在戒烟方面遇到的独特障碍（例如，社会支持低、 性别不安作为一种压力源，需要性别肯定的医疗程序）。 移动医疗、戒烟、跨性别医疗保健、基于社区的参与性研究等方面的专业知识 开发文化适应、试点测试 (R21)，然后正式评估 (R33) TRANSformá Tu Salud Dejando de Fumar（西班牙语，意为“通过戒烟改变你的健康”）——一个文化包容的地方 对跨性别者的戒烟干预。 包括 1) 为期 12 周的基于 WhatsApp 的计划，促进基于多媒体的纵向和双向 （即文本、图像、视频和音频）与参与者对话，以及 2) 与电子药房集成以访问 免费尼古丁替代疗法（NRT）。 R21 目标 1：开发 TRANSformá Tu Salud Dejando de Fumar，一种适应文化的戒烟方法 R21 目标 2：评估可行性、可接受性和初步影响。 TRANSformá Tu Salud Dejando de Fumar 在跨性别者中的应用 R33 目标 1：评估 TRANsformá Tu Salud Dejando de Fumar 的功效。 TRANSformá Tu Salud Dejando de Fumar 与第 6 个月戒烟护理标准的比较 R21-R33 我们将建设移动医疗行为能力。 通过让早期职业研究人员参与指导活动和通过学术研究来进行研究 美国和阿根廷之间的伙伴关系。