Harvard Clinical and Translational Science Center

哈佛临床和转化科学中心

基本信息

批准号：
10622007
负责人：
Lee Marshall Nadler
金额：
$ 1090.42万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-01 至 2030-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10622007
关键词：
Acceleration Address Adopted Boston COVID-19 pandemic Center for Translational Science Activities Clinical Clinical Data Clinical Research Clinical Sciences Clinical Trials Network Clinical effectiveness Collaborations Communities Community Health Competence Democracy EHR research Ecosystem Education Effectiveness Electronic Health Record Elements Equity Evaluation Faculty Geography Goals Health Health Sciences Healthcare Human Informatics Infrastructure Institution Institutional Review Boards Intervention Laboratories Leadership Learning Logic Measures Medical Medicine Mentors Methodology Methods Modeling Multi-Institutional Clinical Trial Ohio Oregon Output Population Heterogeneity Process Assessment Public Health Informatics Public Health Schools Research Research Design Research Personnel Resources Safety Science Secure Special Population Training Translational Research Vision Work catalyst clinical implementation clinical translation cohort digital education resources equity, diversity, and inclusion experience first-in-human health inequalities improved innovation insight interoperability medical schools meetings open data open source patient population pre-clinical prototype research and development sharing platform success tool translational barrier

项目摘要

PROJECT SUMMARY/ ABSTRACT Clinical and translational research (CTR) across Harvard is conducted at 17 independent and geographically dispersed institutions, including Harvard Medical School (HMS), Harvard T. H. Chan School of Public Health, and 15 HMS-affiliated academic health care centers. Each of these institutions is fiscally and operationally independent with their own governance, faculty, IRB, and electronic health records. Harvard Catalyst (HC) serves as the sole coordinating entity for CTR and has brought these institutions together as a federated CTR network. Since 2008, HC has developed a substantial portfolio of educational and CTR resources to meet the needs of the CTR workforce at Harvard and, when their value has been demonstrated at Harvard, disseminated them to the CTSA consortium. Moving forward, HC’s overarching vision is to partner with our CTR workforce, institutions, and communities to become a living clinical and translational science (CTS) learning laboratory. The CTS learning laboratory will continuously assess and reassess the hub’s CTR strengths and weaknesses, developing and implementing programmatic innovations to improve the efficiency, quality, effectiveness, and impact of CTR. Using the principles and methodologies of CTS and guided by a logic model, HC is committed to achieving these goals and overcoming translational roadblocks. Seven translational roadblocks have been prioritized that can be mitigated or overcome: 1) educational resources are not reaching all learners and have been focused on investigators, rather than investigational teams; 2) extensive research resources are frequently invisible and difficult to access; 3) substantial structural and regulatory barriers limit cross-institutional collaborations; 4) research and clinical data need to be connected and their access democratized; 5) CTR workforce is not sufficiently diverse and must be grown in all domains; 6) there is limited access to and participation by diverse populations in research; and 7) insufficient mechanisms exist to support implementation of CTR evidence into practice. HC will also focus on better understanding and meeting the needs of early-stage and underrepresented in medicine investigators and their teams, as well as diverse patient populations and communities, while working to diversify the workforce and reduce health inequities. Multiple initiatives are proposed to address five specific aims: 1) train and diversify the CTR workforce; 2) connect trainees and CTR teams with HC resources; 3) partner with community stakeholders to improve research participation; 4) democratize health informatics; and 5) use CTS to overcome significant CTR roadblocks. HC is eager to learn from other CTSA hubs and is committed to dissemination and sharing across the CTSA consortium. The insights derived from employing CTS approaches will be used to overcome translational roadblocks and advance the collective national goal of improving human health.

项目概要/摘要哈佛大学的临床和转化研究 (CTR) 在 17 个独立的地理机构进行分散的机构，包括哈佛医学院 (HMS)、哈佛大学陈曾熙公共卫生学院、以及 15 个 HMS 附属学术医疗保健中心，每个机构在财政和运营上都有所作为。独立，拥有自己的治理、教师、IRB 和电子健康记录 (HC)。作为 CTR 的唯一协调实体，并将这些机构聚集在一起作为联合 CTR 自 2008 年以来，HC 开发了丰富的教育和 CTR 资源组合，以满足哈佛 CTR 员工的需求，当他们的价值在哈佛得到体现时，将它们分发给 CTSA 联盟，展望未来，HC 的总体愿景是与我们合作。 CTR 员工、机构和社区成为一门活生生的临床和转化科学 (CTS) 学习实验室 CTS 学习实验室将不断评估和重新评估中心的 CTR。优势和劣势，制定和实施计划创新以提高效率，使用 CTS 的原则和方法并以 CTR 为指导的质量、有效性和影响。逻辑模型，HC 致力于实现这些目标并克服转化障碍七。已优先考虑可减轻或克服的转化障碍：1) 教育资源没有覆盖所有学习者，并且关注的是调查人员，而不是研究团队 2) 广泛的研究资源经常是看不见的且难以获取；3）大量的结构和资源；监管限制跨机构合作；4）研究和临床障碍需要联系起来 5) CTR 员工队伍不够多元化，必须在所有领域发展； 6) 不同人群参与研究的机会有限；7) 不足；支持 CTR 实施证据付诸实践的现有机制也将侧重于更好地实施。了解并满足医学研究者及其早期阶段和代表性不足的需求团队以及不同的患者群体和社区，同时努力实现劳动力多元化和减少健康不平等提出了多项举措来实现五个具体目标：1）培训和多样化。 CTR 员工；2) 将学员和 CTR 团队与 HC 资源联系起来；3) 与社区合作；利益相关者提高研究参与度；4）使健康信息学民主化；5）使用 CTS 来克服 HC 渴望向其他 CTSA 中心学习，并致力于传播和推广。通过使用 CTS 方法获得的见解将在 CTSA 联盟中共享。克服转化障碍，推进改善人类健康的国家集体目标。