Preclinical Cardiovascular Disease among Adolescents and Young Adults in Haiti

海地青少年和年轻人的临床前心血管疾病

基本信息

批准号：
10619786
负责人：
Lindsey Reif
金额：
$ 17.39万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-01 至 2027-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10619786
关键词：
Address Adolescent Adolescent and Young Adult Adult Age Age of Onset Area Black American Blood Pressure Cardiovascular Diseases Caring Cessation of life Chronic Clinic Collaborations Communities Complement Data Development Development Plans Disease Disease Outcome Dyslipidemias Early Intervention Ensure Environment Epidemic Epidemiologist Epidemiology Event Evidence based intervention Face Friends Future Generations Goals HIV HIV-1 HIV-infected adolescents Haiti Health High Prevalence Household Incidence Intervention Knowledge Life Cycle Stages Life Expectancy Life Style Measures Mental Depression Mentorship Methods Microalbuminuria Modification Morbidity - disease rate National Heart, Lung, and Blood Institute New York Obesity Outcome Paper Participant Population Prevalence Prevention Primary Prevention Process Prospective, cohort study Provider Psychosocial Factor Publishing Research Research Methodology Research Personnel Risk Risk Factors Services Smoking Stress Time Training Training Support Unhealthy Diet United States National Institutes of Health Viral Load result Youth adolescent health aged antiretroviral therapy cardiometabolism cardiovascular disorder epidemiology cardiovascular disorder risk career career development cohort comorbidity design disability early onset effectiveness evaluation epidemiology study evidence base experience follow-up global health high risk high-risk adolescents implementation framework implementation science improved lifestyle factors low income country member mortality multidisciplinary perinatal HIV population based pragmatic implementation pre-clinical prehypertension premature prevent preventive intervention psychosocial screening skills social stigma therapy duration young adult

项目摘要

PROJECT SUMMARY Dr. Lindsey Reif is a global health epidemiologist with a career goal to leverage epidemiologic research to implement high-impact health interventions for adolescents and young adults living with HIV (AYALH). Over the past decade, she has published 10 first-author papers focused on evaluating health outcomes and interventions among AYALH in Haiti. AYALH, who have survived decades of HIV, now face HIV-related comorbidities, specifically cardiovascular disease (CVD), as they age into adulthood. Her K01 objective is to expand her training and research to focus on HIV-related preclinical CVD— asymptomatic cardiometabolic abnormalities indicating the onset of CVD—among AYALH. She will adapt evidence-based interventions to prevent early onset CVD with impact for AYALH across the lifecourse. Her training objectives are to build expertise in: 1) CVD epidemiology among AYALH, 2) mixed-methods, and 3) implementation science in order to design and implement interventions to prevent CVD morbidity and mortality. Her career development plan includes multidisciplinary mentorship from a team that brings decades of experience in research among AYALH, HIV and CVD epidemiology, and implementation science across global health settings. The team has an impeccable track record of mentorship in global health research. Dr. Reif will also take complementary advanced coursework to support her training objectives. Her K01 is supported by a robust research and training environment that leverages a 40-year collaboration between Weill Cornell (New York) and GHESKIO (Haiti). Dr. Reif’s research plan establishes the epidemiology of preclinical CVD among AYALH and adapts an evidence-based intervention to prevent the onset of preclinical CVD and its progression. She will conduct a prospective cohort study among 500 HIV+ and 500 HIV- participants ages 18-30 years, followed for 3 years in Haiti. In Aim 1, she will evaluate the prevalence, age of onset and progression of preclinical CVD (pre- hypertension, microalbuminuria, and dyslipidemia) by HIV serostatus. She will evaluate risk factors in 3 domains: lifestyle, HIV-related, and psychosocial. She hypothesizes clusters of risk factors, driven by HIV- related and psychosocial factors, are associated with preclinical CVD among AYALH. In Aim 2, she will adapt the evidence-based WHO HEARTS technical package for AYALH in LICs using mixed methods and implementation science. This K01 addresses the knowledge gap of the epidemiology of preclinical CVD among AYALH and informs the adaptation of evidence-based CVD interventions to prevent premature disability and death among this population as they emerge into adulthood. Dr. Reif’s training and career development plan complement and expand her existing skillset and culminate in the submission of an NIH R01 facilitating her transition to independent investigator.

项目概要 Lindsey Reif 博士是一位全球健康流行病学家，其职业目标是利用流行病学研究来对感染艾滋病毒的青少年和年轻人（AYALH）实施高影响力的健康干预措施。过去十年，她发表了 10 篇第一作者论文，重点关注评估健康结果和海地 AYALH 的干预措施随着年龄的增长，她的 K01 目标是减少合并症，特别是心血管疾病 (CVD)。扩大她的培训和研究，重点关注艾滋病毒相关的临床前心血管疾病——无症状心脏代谢她将采取循证干预措施来应对 AYALH 中出现的 CVD 异常。预防早发 CVD，对 AYALH 的整个生命过程产生影响。她的培训目标是建立以下方面的专业知识：1) AYALH 中的 CVD 流行病学，2) 混合方法， 3) 实施科学，以设计和实施预防心血管疾病发病率的干预措施她的职业发展计划包括来自团队的多学科指导，该团队带来了死亡。在 AYALH、HIV 和 CVD 流行病学以及实施科学方面拥有数十年的研究经验该团队在全球卫生领域拥有无可挑剔的指导记录。赖夫博士还将学习补充性高级课程来支持她的培训目标。 K01 得到强大的研究和培训环境的支持，该环境充分利用了 40 年的合作威尔康奈尔（纽约）和 GHESKIO（海地）之间。 Reif 博士的研究计划建立了 AYALH 中临床前 CVD 的流行病学，并采用了她将进行一项基于证据的干预措施，以预防临床前 CVD 的发生及其进展。对 500 名 HIV+ 和 500 名 HIV- 参与者（年龄 18-30 岁）进行的前瞻性队列研究，随访 3 年在目标 1 中，她将评估临床前 CVD 的患病率、发病年龄和进展情况。根据 HIV 血清状态，她将评估 3 种危险因素。她渴望了解由艾滋病毒驱动的一系列风险因素。相关因素和心理社会因素与 AYALH 中的临床前 CVD 相关。在目标 2 中，她将适应。采用混合方法和方法的基于证据的 WHO HEARTS 低收入国家 AYALH 技术包本 K01 解决了临床前 CVD 流行病学方面的知识差距。 AYALH 并告知调整基于证据的 CVD 干预措施以防止过早残疾和赖夫博士的培训和职业发展计划指出了这一人群在成年后的死亡情况。并扩展她现有的技能，并最终提交 NIH R01，以帮助她过渡为独立调查员。