Asian Americans & Racism: Individual and Structural Experiences (ARISE)

亚裔美国人

基本信息

批准号：
10900989
负责人：
Van My Ta Park
金额：
$ 343.21万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-21 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10900989
关键词：
Aging Alcohol consumption Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk American Area Asian Americans Biological Markers Blood Buffers COVID-19 pandemic California Chinese Chronic Clinical Cognition Cognitive Communities Data Data Analyses Data Collection Databases Diabetes Mellitus Discrimination Education Family Foreigner Frequencies Functional disorder Funding Future Glial Fibrillary Acidic Protein Health Hypertension Immigrant Immigration Impaired cognition Individual Koreans Language Life Cycle Stages Light Memory Mental Depression Minority Modeling Multilingualism Neighborhoods Not Hispanic or Latino Obesity Outcome Pacific Islander Participant Prejudice Prevalence Prevalence Study Race Recording of previous events Registries Religion Religion and Spirituality Reporting Research Resources Respondent Risk Risk Factors Role Severities Site Smoking Social support Socioeconomic Status Source Stereotyping Subgroup Surface Surveys United States Vietnamese Visit anti-Asian cardiometabolic risk cardiometabolism cognitive performance cognitive testing cohesion cohort collaborative approach dementia risk executive function experience follow-up hate crimes health disparity health inequalities human old age (65+)neurofilament pandemic disease perceived discrimination physical inactivity protective factors racial bias racial population racism recruit residential segregation resilience sex social determinants sociodemographics tau Proteins tau-1

项目摘要

Project Summary/Abstract Problem-free”, “perpetual foreigner”, “silent minority”, “all the same” – these are stereotypes that have long plagued Asian Americans (ASAs), often referred to as the “model minority”. ASAs, however, encompasses a diversity of cultures, languages, immigration experiences, socioeconomic status (SES), and religions. Racism and discrimination against ASAs are not new but resurfaced with new intensity during the COVID-19 pandemic. Individual and area level racism and discrimination are tied to significant health disparities that influence risk of Alzheimer’s Disease and Related Dementias (ADRD). For ASAs, racism and discrimination at the individual and area level (e.g., residential segregation; redlining) may result in potential cognitive health disparities; however, this area of research in ASAs is understudied. Limited research suggests that at least some ASA groups have lower ADRD risk than non-Hispanic White individuals. Identification of potential protective factors (e.g., family cohesion) that may mitigate racism-related risk is an important scientific opportunity. Studies examining the role of multi-level discrimination related to ASAs’ risk for ADRD are sorely needed but limited. Our proposed study, Asian Americans & Racism: Individual and Structural Experiences (ARISE), guided by the NIA health disparities framework, will develop a multi-site, multi-lingual cohort in California to study the prevalence as well as the impact of multi-level discrimination and resilience resources on associated risk for ADRD among 1,500 older (≥65 years old) Chinese, Korean, and Vietnamese Americans. We will leverage PI Park’s NIA-funded Collaborative Approach for AAPI Research and Education (CARE) registry as one of our recruitment sources. Our specific aims include: 1) Establish the ARISE cohort to determine the prevalence of life course experiences of multi-level discrimination among older Chinese-, Korean-, and Vietnamese Americans; 2) Evaluate the association of multi-level discrimination on cognitive performance and levels of AD biomarkers, overall and by ASA subgroup, sex, and primary language among ARISE participants. Secondary/exploratory Aim: Evaluate the association between multi-level discrimination and cognitive decline; and 3) Evaluate protective and risk factors that modify the effects of multi-level discrimination on cognitive performance and levels of AD biomarkers among ARISE participants. The scientific promise of ARISE is timely and necessary. The COVID-19 pandemic has exposed and exacerbated anti-Asian racism. ARISE will add to our limited understanding of ASAs who are under-represented and under-engaged in ADRD and aging research.

项目概要/摘要 “没有问题”、“永远的外国人”、“沉默的少数”、“都一样”——这些都是刻板印象长期以来一直困扰着亚裔美国人（ASA），通常被称为“模范少数族裔”。然而，涵盖了文化、语言、移民经历的多样性，社会经济地位 (SES) 以及宗教信仰和对 ASA 的歧视则不受此影响。新的，但在 COVID-19 大流行期间以新的强度重新出现。种族主义和歧视与显着的健康差异密切相关，而健康差异影响着种族歧视的风险。阿尔茨海默病和相关痴呆症 (ADRD)，针对 ASA、种族主义和歧视。个人和地区层面（例如，居住隔离；红线）可能会导致潜在的认知健康差异；然而，ASA 的这一领域研究还很有限。研究表明，至少某些 ASA 群体的 ADRD 风险低于非西班牙裔群体识别可能的潜在保护因素（例如家庭凝聚力）。减轻种族主义相关风险是一个重要的科学机会，旨在检验种族主义的作用。我们迫切需要与 ASA 的 ADRD 风险相关的多层次歧视。拟议的研究，亚裔美国人与种族主义：个人和结构经验（ARISE），在 NIA 健康差异框架的指导下，将开发一个多地点、多语言队列加利福尼亚州将研究多层次歧视的流行程度以及影响关于 1,500 名中国老年人（≥65 岁）ADRD 相关风险的复原力资源，我们将利用 PI Park 的 NIA 资助的合作项目。将 AAPI 研究和教育 (CARE) 注册中心作为我们的招聘来源之一。我们的具体目标包括： 1) 建立 ARISE 队列以确定生命的患病率老年中国人、韩国人和韩国人遭受多层次歧视的经历越南裔美国人；2）评估多层次歧视与认知的关联 AD 生物标志物的表现和水平，总体以及按 ASA 亚组、性别和主要分类 ARISE 参与者之间的语言次要/探索性目标：评估关联。多层次歧视和认知能力下降之间的关系；3) 评估保护性和风险性改变多层次歧视对认知表现和水平的影响的因素 ARISE 参与者的 AD 生物标志物的科学承诺是及时且有效的。 COVID-19 大流行暴露并加剧了反亚裔种族主义。将增加我们对 ASA 的有限了解，这些 ASA 代表性不足且参与度不足 ADRD 和衰老研究。