Sensory Mechanisms of Cadmium-Induced Behavioral Disorders Across Generations

镉引起的几代人行为障碍的感觉机制

基本信息

批准号：
10747559
负责人：
Delia S Shelton
金额：
$ 5.02万
依托单位：
UNIVERSITY OF MIAMI CORAL GABLES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-25 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10747559
关键词：
Ablation Acute Adolescent Adult Adverse effects Affect Agriculture Animal Behavior Animals Applications Grants Area Attention Deficit Disorder Behavior Behavior Disorders Behavioral Biological Biological Assay Biology Brain Cadmium Calcium Calcium Oscillations Carcinogens Cells Chemicals Child Chocolate Chronic Cognitive Complement Data Depressed mood Development Diet Dietary Cadmium Dietary Supplementation Disease Doctor of Philosophy Elderly Environment Environmental Risk Factor Environmental Wind Epigenetic Process Etiology Exposure to Eye Fishes Food Fruit Future Generations Gene Expression Generations Genetic Genomics Goals Grain Grant Half-Life Health Heavy Metals Human Immunohistochemistry Immunotoxins Inductively Coupled Plasma Mass Spectrometry Industrialization Ingestion Intake Knowledge Laboratories Lasers Learning Life Link Maps Meat Memory Mental Retardation Mental disorders Mentors MicroRNAs Modeling Molecular Biology Mutagens National Institute of Environmental Health Sciences Necrosis Neurodevelopmental Disorder Neuropsychology Neurosciences Ocular Pathology Outcome Pathology Pathway interactions Peer Review Perception Phase Population Prevalence Prevention Publications Quantitative Reverse Transcriptase PCR Research Research Personnel Research Project Grants Research Support Research Training Reticular Formation Science Selenium Social Behavior Social Development Soil Technical Expertise Testing Therapeutic Effect Time Tissues Toxic effect Toxicogenomics Toxicology Transgenic Organisms Universities Vegetables Vision Visual Visual impairment Visualization Water Work Zebrafish autism spectrum disorder behavioral phenotyping career career development dietary epidemiology study experience hindbrain intergenerational neural neural circuit neurobehavioral neurobehavioral disorder neurocognitive disorder next generation sequencing non-smoking novel parent grant professor programs reproductive research and development response sensory mechanism skills superior colliculus Corpora quadrigemina symposium

项目摘要

PROJECT SUMMARY/ABSTRACT An area of needed exploration is environmentally-induced behavioral disorders. Studies show Cadmium (Cd) toxicity can manifest as behavioral disorders, cognitive challenges, and vision deficiencies in humans, but the pathway for these adverse effects is unknown. Its long biological half-life exacerbates the importance of understanding how early-life Cd exposure impacts later life outcomes and future generations. The parent grant has two aims focused on gaining a mechanistic understanding of cadmium-induced behavioral disorders across generations. Specific Aim 1: Identify the disrupted neural circuitry underlying cadmium-induced visuo-behavioral deficits using whole-brain activity mapping. Specific Aim 2: Inter- and transgenerational effects of cadmium-induced behavioral disorders. The parent grant for this proposal is R00ES030398 to launch Dr. Delia Shelton’s career as an independent scientific investigator as an Assistant professor in the Department of Biology at University of Miami, where she draws on her scientific background in animal behavior, toxicology, neuroscience and genomics. Dr. Shelton has extensive experience in understanding behavioral phenotyping and cadmium toxicity which is completed by professional skills in mentoring that she gained in her graduate studies and during the K99 phase of the grant, permitting her to become a successful independent researcher and leader in behavioral toxicology. In her new laboratory, Dr. Shelton proposes to test the hypothesis that chronic human dietary-relevant Cd exposure leads to visuo-behavioral disorders later in life and across generations. In the proposed supplement, Dr. Shelton will mentor the Diversity Supplement candidate, Myles Covington, in pursuing a research project that complements and extends the aims of the parent grant, thereby creating a unique opportunity. The focus of this application submitted under PA-21-071 “Research Supplements to Promote Diversity in Health-Related Research” is to support the research training and career development of Myles Covington through studying the potential therapeutic effects of selenium supplementation for dietary cadmium-induced toxicity on visually- guided behavior. Research and career development activities are proposed to expand their technical skill set, enhance their knowledge in toxicology, molecular biology and genomics, and provide opportunities for professional development including networking disseminating science at conferences and through peer- reviewed publications, which will enhance their ability to pursue a PhD in toxico-genomics.

项目概要/摘要需要探索的一个领域是环境引起的行为障碍研究表明镉 (Cd)。毒性可表现为人类行为障碍、认知障碍和视力缺陷，但这些不良反应的途径尚不清楚，其较长的生物半衰期加剧了其重要性。了解生命早期的镉暴露如何影响以后的生活结果和后代。有两个目标，重点是获得对镉引起的行为障碍的机制理解跨越几代人。具体目标 1：确定镉引起的视觉行为缺陷背后的受损神经回路使用全脑活动图。具体目标 2：镉引起的行为障碍的代际和跨代影响。该提案的家长拨款为 R00ES030398，用于启动 Delia Shelton 博士作为独立人士的职业生涯科学研究员，迈阿密大学生物系助理教授，她在那里谢尔顿博士借鉴了她在动物行为、毒理学、神经科学和基因组学方面的科学背景。在了解行为表型和镉毒性方面拥有丰富的经验，已完成凭借她在研究生学习和 K99 阶段获得的专业指导技能授予，使她成为行为毒理学领域成功的独立研究员和领导者。谢尔顿博士在她的新实验室中提议检验以下假设：慢性人类饮食相关的镉接触会导致晚年和几代人的视觉行为障碍。谢尔顿博士将指导多样性补充候选人迈尔斯·卡温顿 (Myles Covington) 开展一项研究项目这补充并扩展了母基金的目标，从而创造了一个独特的机会。根据 PA-21-071“促进健康相关多样性的研究补充”提交的本申请的内容研究”是通过研究支持迈尔斯·卡温顿的研究培训和职业发展补充硒对膳食镉引起的视觉毒性的潜在治疗作用建议开展研究和职业发展活动来扩展他们的技术技能，增强他们在毒理学、分子生物学和基因组学方面的知识，并为他们提供机会专业发展，包括在会议上和通过同行传播科学的网络审阅出版物，这将提高他们攻读毒物基因组学博士学位的能力。