Childhood Allergy and the NeOnatal Environment in St Louis (CANOE-STL) and the Impact of Wheezing Illnesses on Neurocognitive Development of Preschool Children

圣路易斯儿童过敏和新生儿环境 (CANOE-STL) 以及喘息疾病对学龄前儿童神经认知发展的影响

• 批准号: 10745142
• 负责人: Katherine Rivera-Spoljaric
• 金额: $ 148.78万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745142
• 关键词: Adrenal Cortex Hormones; Affect; Age; Allergic rhinitis; Asthma; Award; Behavioral; Brain; Child; Childhood; Chronic; Chronic Disease; Cognition; Cognitive; Cohort Studies; Communities; Data; Data Analyses; Development; Diabetes Mellitus; Disease; Educational Activities; Emergency department visit; Emotional; Emotions; Ensure; Environment; Environmental Risk Factor; Focus Groups; Health; Healthcare; Heart Diseases; Hospitalization; Hypersensitivity; IL17 gene; IL4 gene; IL5 gene; IL6 gene; Infant; Infant Development; Inflammatory; Inhalation; Interleukin-13; Interview; Language; Length; Linear Models; Measures; Mental Depression; Mental Health; Mothers; Motor; Neonatal; Neurocognitive; Newsletter; Nursery Schools; Oncology; Parents; Participant; Patients; Peripheral; Pharmaceutical Preparations; Physicians; Preschool Child; Protocols documentation; Publishing; Questionnaires; Recurrence; Reporting; Research; Severity of illness; Sickle Cell; Site; Social support; Socioeconomic Status; Steroids; Stress; Structure; Surveys; Toddler; Traumatic Brain Injury; United States National Institutes of Health; Visit; Wheezing; behavior measurement; care burden; cohort; design; early childhood; eosinophil; equity, diversity, and inclusion; experience; infancy; inflammatory marker; offspring; participant retention; pregnant; prenatal; psychosocial; recruit; sample collection; social; success

Project Summary Wheezing during preschool years is a common occurrence [1] causing significant healthcare burden [2] with frequent unscheduled physician visits, ED visits, hospitalizations, and treatment with inhaled and systemic corticosteroids along with other medications. Recurrent wheezing is often the antecedent to asthma, one of the most common chronic diseases of childhood. Though there is evidence of significant neurocognitive problems in children with other chronic health conditions such as oncological diseases, diabetes, heart disease, sickle cell, and traumatic brain injury [3], the impact of recurrent wheezing illnesses and associated treatment on the neurocognitive and emotional development of infants and preschool children has not been fully characterized. The ECHO cohort study has been collecting neurodevelopmental measures in children after the late preschool years; however, critical neurodevelopmental trajectories occur in early infancy [4]. Data suggest that these trajectories can be affected by pre-natal conditions, socioeconomic status, stress, disease severity, and/or medication use. A recent study, in non-asthmatic patients, showed that the use of systemic corticosteroids, a frequently administered treatment for wheezing illnesses, was associated with changes in brain structure [5]. Building on these findings, our overarching study objective is to understand the association of recurrent wheezing illnesses and its associated treatment on the neurocognitive and emotional development of infants and preschool children.

项目概要 学龄前儿童喘息是一种常见现象 [1]，造成严重的医疗负担 [2] 频繁的计划外就诊、急诊就诊、住院治疗以及吸入性和全身性治疗 皮质类固醇与其他药物一起使用。反复喘息通常是哮喘的先兆，哮喘是哮喘的先兆之一。 儿童期最常见的慢性疾病。尽管有证据表明存在严重的神经认知问题 患有其他慢性健康问题的儿童，如肿瘤疾病、糖尿病、心脏病、镰状细胞病、 和创伤性脑损伤 [3]，复发性喘息疾病及相关治疗对 婴幼儿和学龄前儿童的神经认知和情感发展尚未得到充分 特点。 ECHO 队列研究一直在收集儿童在 学龄前后期；然而，关键的神经发育轨迹发生在婴儿早期[4]。数据表明 这些轨迹可能受到产前条件、社会经济地位、压力、疾病严重程度、 和/或药物使用。最近一项针对非哮喘患者的研究表明，使用全身疗法 皮质类固醇是治疗喘息疾病的常用药物，与大脑的变化有关 结构[5]。基于这些发现，我们的总体研究目标是了解这种关联 复发性喘息疾病及其对神经认知和情绪的相关治疗 婴儿和学龄前儿童的发育。