Biomedical Resource Core

生物医学资源核心

基本信息

批准号：
10747705
负责人：
Paul A Welling
金额：
$ 28.59万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10747705
关键词：
Acceleration Address Affect Animals Basic Science Behavior Therapy Biological Models Biology Biometry Black race Calorimetry Chronic Kidney Failure Clinical Research Clinical Sciences Cohort Studies Collaborations Collection Communities Complex Consultations DASH diet Data Data Set Diabetic Nephropathy Diet Dietary Assessment Disease Outcome Disease Progression Disparity Electrolytes Equipment Fiber Food Fostering Genetic Models Germ-Free Goals Health Food Homeostasis Human Hypertension Immunologics Influentials Intervention Studies Investigation Joints Kidney Kidney Diseases Laboratories Laboratory Research Metabolic Metabolism Minority Modeling Molecular Mus Nutritional Obesity Obesity Epidemic Observational Study Pathway Analysis Periodicals Persons Phenotype Physiology Pilot Projects Population Population Heterogeneity Potassium Potassium Deficiency Prevention Procedures Process Protocols documentation Quality Control Race Research Research Design Research Personnel Research Project Grants Resources Role Services Sodium Specimen Stress Study models Technology Training Trans Fats Translational Research Translations Unhealthy Diet Validation biobank biomedical resource burden of illness carbohydrate metabolism caucasian American design dietary disease disparity disorder risk epidemiology study ethnic minority population experience experimental study feeding follow-up food insecurity fundamental research gene discovery health disparity health equity health equity promotion human model humanized mouse innovation lipid metabolism marginalized community member microbiome mouse model pre-clinical research racial disparity racial minority population saturated fat social social health determinants social stress social stressor socioeconomic disparity socioeconomics stressor sugar tool translational pipeline translational study

项目摘要

ABSTRACT The Biomedical Resource Core (BRC) of the Johns Hopkins O’Brien Center to Advance Kidney Health Equity will provide an innovative portfolio of research services, resources, and tools for investigators to understand and ameliorate disparities in kidney disease, towards ultimately achieving kidney health equity. With a focus on dietary and social stresses that drive kidney health disparities, the BRC is uniquely designed to address this fundamental challenge with a broad impact, advancing kidney research nationally. A Clinical Science Dietary and Social Stressor Laboratory (C-DSSL) directed by Dr. Lawrence Appel, and a Basic Science Dietary and Social Stressor Laboratory (B-DSSL), directed by Dr. Paul Welling provide expert consultation, proven protocols, training, access to materials and equipment; and will execute pilot studies or larger research projects. A joint consultation service, and a deliberate team approach meld the two laboratories, and create an innovative bidirectional pipeline that maximizes translation. The C-DSSL will provide the following services : 1) clinical study design; 2) dietary assessment; 3) access to numerous large cohort studies, with racially and socioeconomically diverse populations, deep phenotyping and collection of dietary data, stored biospecimens, and long follow-up periods; 4) feeding studies modeled on the Dietary Approaches to Stop Hypertension trials; 5) behavioral intervention studies; 6) translational studies in the community; 7) use of publicly available datasets; and 8) biostatistical support. The B-DSSL will provide investigators with comprehensive services and resources for preclinical research to determine the mechanistic underpinnings of human health disparity stressors, using mice as a model system; services will include: 1) study design; 2) humanized mouse diet protocols; 3) a comprehensive mouse kidney phenotyping core for exploring stress mechanisms from whole animal physiology to molecular mechanism; 4) a lipid and carbohydrate metabolism phenotyping core, equipped with state-of-the-art metabolic cages for calorimetry; 5) a core for studying immunological manifestations of dietary and social stressors in the kidney; 6) a microbiome core with a state-of-the-art germ- free facility; and 7) a mouse biobank of dietary and social stress models. All shared services and resources will undergo strict quality control, validation, and periodic review of demand and impact. In addition to the services provided by the laboratories and their integrated approach, the BRC will foster training and capacity building to maximize entry of early-stage investigators from diverse fields new to kidney health equity research. The BRC is committed to collaborating with the consortium broadly, and to freely sharing its specialized resources.

抽象的约翰·霍普金斯大学奥布莱恩中心的生物医学资源核心 (BRC) 旨在促进肾脏健康公平将提供创新的研究服务、资源和工具组合，供研究人员了解改善肾脏疾病的差异，最终实现肾脏健康公平。饮食和社会压力导致肾脏健康差异，BRC 的独特设计就是为了解决这个问题具有广泛影响的根本性挑战，推动全国肾脏研究。由 Lawrence Appel 博士指导的社会压力源实验室 (C-DSSL)，以及基础科学饮食和 Paul Welling 博士指导的社会压力源实验室 (B-DSSL) 提供专家咨询，经过验证协议、培训、材料和设备的获取；并将执行试点研究或更大规模的研究联合咨询服务和仔细的团队方法融合了两个实验室，并创建了一个最大化翻译的创新双向管道 C-DSSL 将提供以下服务：1) 临床研究设计；2) 饮食评估；3) 获得大量针对种族和群体的研究社会经济多样化的人群、深入的表型分析和饮食数据的收集、存储的生物样本、和长期随访；4）以饮食方法控制高血压试验为模型的喂养研究； 5) 行为干预研究； 6) 社区转化研究； 7) 公开资料的使用；数据集；和 8) 生物统计支持 B-DSSL 将为研究者提供全面的服务和支持。用于确定人类健康差异的机制基础的临床前研究资源压力源，使用小鼠作为模型系统；服务将包括：1）研究设计；2）人性化小鼠饮食； 3) 全面的小鼠肾脏表型分析核心，用于探索整体应激机制动物生理学到分子机制4）脂质和碳水化合物代谢表型核心；配备最先进的量热代谢笼5) 用于研究免疫学的核心；肾脏中饮食和社会压力的表现；6）具有最先进细菌的微生物组核心免费设施；7）饮食和社会压力模型的小鼠生物库所有共享服务和资源。将接受严格的质量控制、验证以及对需求和影响的定期审查。实验室提供的服务及其综合方法，BRC 将促进培训和能力建设旨在最大限度地吸引来自不同领域的早期研究人员进入肾脏健康公平研究。 BRC 致力于与该联盟广泛合作，并自由分享其专业知识资源。