Household Air Pollution, Adiposity, and Cardiorenal Disease Risk in Children

家庭空气污染、肥胖和儿童心肾疾病风险

基本信息

批准号：
10739062
负责人：
Margaret O. Murphy
金额：
$ 13.23万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10739062
关键词：
18 year old Address Adipocytes Adolescent Adolescent obesity Adult Adverse effects Air Animals Appearance Biological Markers Biometry Blood Pressure Cardiorenal syndrome Cardiovascular Abnormalities Cardiovascular Diseases Cardiovascular system Charcoal Child Childhood Chronic Chronic Kidney Failure Cities Classification Clinic Clinical Research Coal Coronary Arteriosclerosis Devices Diabetes Mellitus Diagnosis Diameter Disease Diurnal Rhythm Early Intervention Environment Environmental Exposure Environmental Impact Exposure to Filtration Fire - disasters Goals Health Health Care Costs High School Student Home Household Household Air Pollution Human Hyperlipidemia Hyperplasia Hypertension Hypertrophy IL6 gene Inflammation Inflammatory Intervention Investigation Kentucky Kidney Left Ventricular Hypertrophy Link Literature Measurement Measures Medical Mentors Morbidity - disease rate Nephrology Obesity Participant Particulate Matter Patient Recruitments Patients Pediatric Hospitals Pilot Projects Population Prevalence Prevention strategy Public Health Publishing Random Allocation Research Risk Risk Factors Role Rural Population Severities Surveys TNF gene Testing Training Programs Translational Research United States Variant Wood material Wood stove Youth adipokines adiponectin age group aged ambient air pollution blood pressure regulation burden of illness cardiovascular disorder risk cardiovascular health cardiovascular risk factor career career development circadian coarse particles cohort disorder risk fine particles high body mass index high risk high risk population improved insight instrumentation intercellular cell adhesion molecule low socioeconomic status meter mortality obesity in children pollutant rational design recruit risk stratification solid fuel statistics synergism systemic inflammatory response ultrafine particle ventilation wasting

项目摘要

ABSTRACT Childhood obesity is a major public health threat with rates increasing at an alarming rate worldwide. Currently 22.4% of children and adolescents are obese, approximately 16.7 million, with rates of obesity increasing in all age groups in the pediatric population. Obese children are more likely to be diagnosed with several major morbidities (hypertension, hyperlipidemia, coronary artery disease, and diabetes). The estimated annual health care costs of obesity- related illness are a staggering $190.2 billion or nearly 21% of annual medical spending in the United States. Household air pollution (HAP) is a term that describes the health and environmental impacts of pollutants produced from incomplete combustion of solid fuels such as wood, coal, charcoal, animal dung, crop wastes burnt on open fires or wood-burning stoves in poorly ventilated homes and releases suspended particulate matter (PM). There are few studies examining the role of household air pollution including PM2.5 in cardiovascular risk in the setting of pediatric obesity. An important component of cardiovascular health is a diurnal variation of blood pressure, where nocturnal levels are approximately 20% lower than daytime values. The absence of nocturnal BP-dipping in childhood may be an important indicator of early disease risks and our team has recently published evidence that childhood obesity is associated with non-dipping. The specific project proposed here will test the hypothesis that exposure to household air pollution increases cardiovascular risk in obese children through an inflammation- related disruption in diurnal BP regulation. This project will recruit patients aged 10-18 to define relationships between at-home air quality and hypertension risk factors. A pilot study to determine the impact of high efficacy particulate matter (HEPA) filtration units on air quality exposure and health risks will be measured in these patients as well. This research addresses a significant public health issue by understanding and identifying environmental exposures in a vulnerable high-risk group of rural children in order to develop new treatments to improve their health.

抽象的儿童肥胖是一个主要的公共卫生威胁，其发病率正以惊人的速度增长全世界。目前22.4%的儿童和青少年肥胖，约1670万人，儿科人群中所有年龄段的肥胖率都在增加。肥胖儿童是更有可能被诊断出患有几种主要疾病（高血压、高脂血症、冠状动脉疾病和糖尿病）。估计每年肥胖的医疗费用- 相关疾病的费用高达 1,902 亿美元，占美国年度医疗支出的近 21% 美国。家庭空气污染 (HAP) 是一个描述健康和健康的术语固体燃料不完全燃烧产生的污染物对环境的影响，例如在明火或燃木火炉上燃烧的木材、煤炭、木炭、动物粪便、农作物废物通风不良的房屋并释放悬浮颗粒物 (PM)。研究还很少检查包括 PM2.5 在内的家庭空气污染对心血管风险的影响小儿肥胖症。心血管健康的一个重要组成部分是昼夜节律变化夜间血压比白天低约 20%。这儿童时期没有夜间血压下降可能是早期疾病的一个重要指标风险，我们的团队最近发表的证据表明儿童肥胖与非浸渍。这里提出的具体项目将测试以下假设：家庭空气污染通过炎症增加肥胖儿童的心血管风险昼夜血压调节的相关破坏。该项目将招募10-18岁的患者来定义家庭空气质量与高血压危险因素之间的关系。一项试点研究确定高效颗粒物 (HEPA) 过滤装置对空气质量的影响还将对这些患者的暴露和健康风险进行测量。这项研究解决了一个通过了解和识别环境暴露的重大公共卫生问题农村儿童的弱势高危群体，以开发新的治疗方法来改善他们的健康。