Training Program in Rheumatic and Musculoskeletal Diseases Research

风湿病和肌肉骨骼疾病研究培训计划

基本信息

批准号：
10628089
负责人：
John D Mountz
金额：
$ 35.42万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-01 至 2028-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628089
关键词：
Musculoskeletal Diseases Research Rheumatism Training Programs

项目摘要

PROJECT SUMMARY The UAB Training Program in Rheumatic and Musculoskeletal Disease Research (Director: John D. Mountz, MD, PhD; co-Director: Kenneth Saag, MD, MSc; and Associate Director: Andre Ballesteros, PhD) is built on the longstanding strengths in adult and pediatric rheumatology, immunology, musculoskeletal medicine, and our expertise in both early and later phase translational investigation. Over a past 5 year funding period, we built a highly successful program with an outstanding group of core mentors, a comprehensive and flexible training plan, and a balanced mix of basic and clinical trainees from a diverse set of backgrounds. In this resubmission application, we seek to continue to focus on training and career development of highly qualified pre-doctoral and postdoctoral (PhD, MD/PhD, or MD) trainees who are committed to careers in biomedical research that will serve the mission of NIAMS. This program has brought together the Divisions of Clinical Immunology and Rheumatology and Pediatric Rheumatology, the Comprehensive Arthritis, Musculoskeletal, Bone, and Autoimmunity Center (CAMBAC), and other directly relevant departments and programs to provide a vibrant and effective interdisciplinary training environment. The proposed research training program will continue to enhance the integrated, interwoven fabric of collaborative science, which ranges from fundamental molecular discovery to applied clinical and translational research. It incorporates an established, well-funded faculty committed to training in rheumatic and musculoskeletal diseases (RMDs). We have organized our program around three groups of mentors represent a diverse set of UAB Departments and Programs at UAB: 1. Core Mentors: established, extramurally (primarily NIH) funded investigators with programs focused on RMDs committed to training the next generation of researchers; 2. Content Mentors: a) clinicians or researchers with expertise in RMDs but whose role is primarily supportive; or with research funding in areas complementary to, or synergistic with, RMDs; and 3. Mentors in Training: Early career faculty who will be developed into outstanding research mentors to further strengthen the RMD research environment. Trainees will be selected for their commitment to research and academic medicine, and the members of the UAB training faculty are fully committed to continuing to provide mentorship, support, and guidance to additional young investigators to help them develop into independent researchers who will advance our knowledge of RMDs. The UAB Rheumatology T32 program reflects a focused, relevant, multi-disciplinary translational research training program at UAB. Our training program has assembled an outstanding core of scientific mentors and is uniquely prepared and strongly committed to training of the next generation of rheumatic and musculoskeletal disease investigators and generate knowledge relevant to the mission and priorities of the NIAMS and the nation.

项目概要 UAB 风湿病和肌肉骨骼疾病研究培训计划（主任：John D. Mountz，医学博士，博士；联合主任：Kenneth Saag，医学博士、理学硕士；和副主任：Andre Ballesteros 博士）建立在在成人和儿童风湿病学、免疫学、肌肉骨骼医学以及我们的早期和后期转化研究的专业知识。在过去 5 年的资助期内，我们建立了项目非常成功，拥有优秀的核心导师团队，全面灵活的培训计划，来自不同背景的基础和临床学员的均衡组合。在这次重新提交中应用，我们寻求继续关注高素质博士前和博士生的培训和职业发展致力于生物医学研究职业的博士后（PhD、MD/PhD 或 MD）学员 NIAMS 的使命。该计划汇集了临床免疫学和风湿病学部门和小儿风湿病学、综合关节炎、肌肉骨骼、骨骼和自身免疫中心（CAMBAC）和其他直接相关的部门和计划，以提供充满活力和有效的跨学科的培训环境。拟议的研究培训计划将继续加强协作科学的综合、交织结构，范围从基础分子发现到应用临床和转化研究。它拥有一支资金雄厚、致力于培训的师资队伍风湿病和肌肉骨骼疾病（RMD）。我们围绕三组组织了我们的计划导师代表 UAB 的不同部门和项目： 1. 核心导师：已建立、外部（主要是 NIH）资助研究人员开展专注于 RMD 的项目，致力于培训下一代研究人员； 2. 内容导师： a) 具有 RMD 专业知识但其角色主要是支持性的；或在互补或协同领域提供研究经费 RMD； 3. 培训导师：将发展成为杰出研究人员的早期职业教师导师进一步加强 RMD 研究环境。学员将根据他们的承诺而被选拔研究和学术医学，UAB 培训教员的成员完全致力于继续为更多年轻研究者提供指导、支持和指导，帮助他们成长为独立研究人员将增进我们对 RMD 的了解。 UAB 风湿病学 T32 计划反映阿拉巴马大学的一个重点突出、相关、多学科的转化研究培训项目。我们的培训计划有组建了一支杰出的科学导师核心队伍，并做好了独特的准备并坚定地致力于培训下一代风湿病和肌肉骨骼疾病研究人员，并产生与以下疾病相关的知识 NIAMS 和国家的使命和优先事项。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Repositioning drugs by targeting network modules: a Parkinson's disease case study.

通过针对网络模块重新定位药物：帕金森病案例研究。

DOI：
发表时间：
2017
期刊：
影响因子：
3
作者：
Yue, Zongliang;Arora, Itika;Zhang, Eric Y;Laufer, Vincent;Bridges, S Louis;Chen, Jake Y
通讯作者：
Chen, Jake Y

ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages.

ACVR1R206H 延长了人诱导多能干细胞来源的巨噬细胞的炎症反应。

DOI：
发表时间：
2021-12
期刊：
影响因子：
4.1
作者：
Matsuo, Koji;Lepinski, Abigail;Chavez, Robert D;Barruet, Emilie;Pereira, Ashley;Moody, Tania A;Ton, Amy N;Sharma, Aditi;Hellman, Judith;Tomoda, Kiichiro;Nakamura, Mary C;Hsiao, Edward C
通讯作者：
Hsiao, Edward C

The Potential of Harnessing IL-2-Mediated Immunosuppression to Prevent Pathogenic B Cell Responses.

利用 IL-2 介导的免疫抑制来预防致病性 B 细胞反应的潜力。

DOI：
发表时间：
2021
期刊：
影响因子：
0
作者：
Papillion, Amber;Ballesteros
通讯作者：
Ballesteros

Juvenile Idiopathic Arthritis: Oligoarthritis and Polyarthritis.

幼年特发性关节炎：少关节炎和多关节炎。

DOI：
发表时间：
2018
期刊：
影响因子：
2.6
作者：
Crayne, Courtney B;Beukelman, Timothy
通讯作者：
Beukelman, Timothy

Satisfaction with modes of telemedicine delivery during COVID-19: A randomized, single-blind, parallel group, noninferiority trial.

COVID-19 期间对远程医疗交付模式的满意度：一项随机、单盲、平行组非劣效性试验。

DOI：
发表时间：
2022-11
期刊：
影响因子：
0
作者：
Danila, Maria I;Sun, Dongmei;Jackson, Lesley E;Cutter, Gary;Jackson, Elizabeth A;Ford, Eric W;DeLaney, Erin;Mudano, Amy;Foster, Phillip J;Rosas, Giovanna;Melnick, Joshua A;Curtis, Jeffrey R;Saag, Kenneth G
通讯作者：
Saag, Kenneth G