Training Program in Investigative Gastroenterology and Hepatology

胃肠病学和肝病学研究培训计划

• 批准号: 10628499
• 负责人: SCOTT L. FRIEDMAN
• 金额: $ 26.83万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628499
• 关键词: Gastroenterology; Hepatology; Training Programs

The burden of digestive diseases in the United States is staggering, with annual costs exceeding $140 billion, based on National Institutes of Health (NIH) estimates. To meet this challenge, a key mission of the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) is to support the training of a talented, diverse pool of young investigators who will attack scientific unmet needs to improve the lives of patients with gastrointestinal and liver diseases. The Icahn School of Medicine at Mount Sinai (ISMMS) has been a center of excellence for care in gastrointestinal and liver diseases for decades, with clinical fellowship programs in these disciplines consistently ranked among the best in the country. Moreover, ISMMS offers a fertile environment from which a cadre of outstanding candidates have launched successful careers in academic gastroenterology and hepatology. The overarching goal of this Training Program proposal is to leverage this outstanding environment to support the training of M.D., M.D./Ph.D or Ph.D. postdoctoral fellows by providing exceptional research opportunities and mentorship in three broad areas: A) Gastrointestinal inflammation and the microbiome; B) Non-alcoholic steatohepatitis (NASH), hepatic inflammation and fibrosis; and C) Genetics of gastrointestinal and liver diseases. The highly structured training program provides a tailored curriculum that integrates clinico-epidemiologic-, genetic-, environmental- and cellular/molecular research excellence. The program is built upon a foundation of world class research faculty who have outstanding track records of academic achievement and successful mentorship. The curriculum focuses on cross-disciplinary training in order to prepare trainees for the current and future challenges of gastrointestinal and liver disease research, which now requires integration of complementary research skill sets. To address this need, a highly selected pool of mentors has been chosen not only from within the Divisions of GI and Liver Diseases and other clinical disciplines, but who also represent outstanding multi-disciplinary institutes at the ISMMS. Each year this program will support 3 trainees (PGY 4 - PGY 6), with 15 candidates entering the program over 5 years. Each trainee will pursue an individualized research project and tailored curriculum formulated together with their primary and secondary mentors, curriculum committee and the Program Directors. Trainees will dedicate at least 90% effort in either the laboratory or clinical setting, and their progress will be monitored through quarterly meetings with their advisory committee and program directors. Overall quality and adaptability of the program will be ensured through oversight by internal and external advisory boards, based on compliance with defined metrics of success for both individual trainees and the overall program. This rigorously structured and closely monitored program, committed to excellence and built upon a rich scientific environment and outstanding faculty, will yield superbly trained future leaders in investigative gastroenterology and hepatology.

美国消化系统疾病的负担令人震惊，每年花费超过1400亿美元， 根据美国国立卫生研究院 (NIH) 的估计。迎接这一挑战是国家的一项重要使命 糖尿病、消化和肾脏疾病研究所 (NIDDK) 旨在支持培训有才华的、多元化的人才 一群年轻的研究人员将致力于解决未满足的科学需求，以改善患有癌症的患者的生活 胃肠道和肝脏疾病。 西奈山伊坎医学院 (ISMMS) 一直是胃肠道护理的卓越中心 几十年来，这些学科的临床研究金项目始终名列前茅 全国最好的。此外，ISMMS 还提供了一个肥沃的环境，可以培养优秀的骨干队伍。 候选人已在胃肠病学和肝病学领域开启了成功的职业生涯。首要的 该培训计划提案的目标是利用这一出色的环境来支持培训 M.D.、M.D./Ph.D 或 Ph.D.博士后研究员提供特殊的研究机会和指导 三大领域：A) 胃肠道炎症和微生物组； B) 非酒精性脂肪性肝炎 (NASH)、肝脏炎症和纤维化； C) 胃肠道和肝脏疾病的遗传学。高度 结构化培训计划提供量身定制的课程，整合了临床流行病学、遗传学、 卓越的环境和细胞/分子研究。该计划建立在世界一流的基础上 研究人员拥有杰出的学术成就和成功的指导记录。这 课程侧重于跨学科培训，以使学员为当前和未来的挑战做好准备 胃肠道和肝脏疾病研究，现在需要整合互补的研究技能 套。为了满足这一需求，我们不仅从各部门内部挑选了一批经过精心挑选的导师 胃肠道和肝脏疾病以及其他临床学科的专家，但他们也代表了杰出的多学科 ISMMS 的研究所。 该计划每年将支持 3 名学员（PGY 4 - PGY 6），超过 15 名候选人进入该计划 5年。每位学员都将进行个性化的研究项目和共同制定的定制课程 与他们的小学和中学导师、课程委员会和项目总监。学员将 在实验室或临床环境中投入至少 90% 的努力，他们的进展将通过以下方式进行监控 每季度与咨询委员会和项目主管举行会议。综合素质和适应性 将通过内部和外部咨询委员会的监督，在遵守以下规定的基础上确保计划的实施 为个别受训者和整个项目定义了成功的衡量标准。这种结构严谨、 密切监控的计划，致力于卓越并建立在丰富的科学环境和杰出的 教师，将培养训练有素的未来胃肠病学和肝病学领域的领导者。