Biological and social mediators of child wellbeing among ethnic groups in Fragile Families

脆弱家庭中族裔群体儿童福祉的生物和社会中介因素

基本信息

批准号：
10627765
负责人：
DANIEL A. NOTTERMAN
金额：
$ 58.81万
依托单位：
PRINCETON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10627765
关键词：
15 year old African Age Alleles American Assessment tool Attention Award Behavior Behavioral Genetics Biological Biological Assay Biological Markers Biosocial Birth Black race Blood Body mass index Characteristics Child Child Behavior Child Development Child Health Child Welfare Cities Cognition Collection Communities Computational Biology Consensus Copy Number Polymorphism DNA DNA Methylation Data Data Set Dryness Epigenetic Process Ethnic Population Family Funding Gene Expression Genes Genetic Genotype Health Hispanic Immigrant Individual Leadership Length Letters Longitudinal Studies Maternal Behavior Maternal Health Measurement Measures Mediation Mediator Mental Depression Methylation Mothers Neonatal Outcome Parents Pathway interactions Personal Satisfaction Phenotype Physical environment Policy Maker Population Poverty Price Problem behavior Quantitative Trait Loci Research Research Design Resources Saliva Sampling Science Scientist Services Social Environment Social Sciences Source Spottings Standardization Stress Testing Variant Vulnerable Populations Work behavior influence behavioral outcome cognitive ability cohort economic outcome epigenome-wide association studies ethnic minority ethnic minority population experimental study externalizing behavior genome-wide health of the mother meetings multi-ethnic polygenic risk score population based racial minority sample collection social social science research statistics symposium telomere tool

项目摘要

Project Summary Since 2000, the Fragile Families and Child Wellbeing Study (FFCWS) has provided the social science community with data on a longitudinal birth cohort of nearly 5000 American children born in large cities. FFCWS contains a large number of racial and ethnic minorities: 47% Black children, 27% Hispanic children (17% children born to immigrant Hispanic parents). Approximately 40% of the families live below the poverty line. These features make the data unique among other large-scale, longitudinal studies, and thus well-suited for studying the health and wellbeing of vulnerable populations. Under the current award (R01HD076592), our team has developed a large portfolio of genetic, epigenetic and telomere length (TL) data for children at ages 9 and 15 years. While originally funded to produce an analysis of 197 SNP variants in 72 genes (in a subset of the subjects), we have been able to leverage price reductions and other funding to provide genotypes on approximately 3000 children. These data will be made available to the research community this year, as will TL data for all children at 9 and 15 years of age. The DNA methylation effort has expanded to 2200 paired samples of children (at 9 and 15 years) from the originally funded 500 samples. We plan to make these data available in 2020, when measurement is complete. Continuing the tradition of service that has marked FFCWS from the beginning, in the first year of this renewal project, we will: Aim 1, develop a portfolio of relatively new measures to include: a) multiple polygenetic scores (PGS), including several that exploit gene expression or experimental data to enhance the predictive power for particular phenotypes, b) CNV annotated to gene, c) epigenetic constructs for children, such as methylation age, methylation quantitative trait loci (meQTL) and epigenome-wide association study (EWAS)-derived summary scores, based on genetic and DNA methylation data. All of these derived measures would be completed and made publicly available by year 1 of an award. These statistics will provide important new tools for the genetic assessment of ethnic minority populations. Aim 2, genotype the FFCWS mothers with a multi-ethnic array, allowing a study of parental effects on child health, behavior, and wellbeing through both genetic (including genetic nurturance) and social pathways. This work takes on greater value due to recent calls to expand genome- wide work for non-European ancestry (in particular African and Hispanic) individuals and in children. In Aim 3, we explore best practices around collection, processing and storage of DNA for large scale TL research involving saliva, fresh blood, and stored neonatal dried blood spots (nDBS). These experiments will help fuel a consensus conference associated with the Biomarker Network meeting held with the Population Association of America.

项目概要自 2000 年以来，脆弱家庭和儿童福祉研究 (FFCWS) 为社会科学界提供了包含近 5000 名在大城市出生的美国儿童的纵向出生队列数据。 FFCWS 包含一个大量种族和族裔少数群体：47% 是黑人儿童，27% 是西班牙裔儿童（17% 出生于西班牙裔移民父母）。大约40%的家庭生活在贫困线以下。这些功能使这些数据在其他大规模纵向研究中是独一无二的，因此非常适合研究健康和弱势群体的福祉。根据当前奖项（R01HD076592），我们的团队开发了遗传、表观遗传和 9 岁和 15 岁儿童的端粒长度 (TL) 数据。虽然最初资助是为了进行分析 72 个基因中的 197 个 SNP 变异（在受试者的一个子集中），我们已经能够利用降价和其他资金用于为大约 3000 名儿童提供基因型。这些数据将提供给今年，研究界将发布所有 9 岁和 15 岁儿童的 TL 数据。 DNA甲基化此项工作已从最初资助的 500 名儿童配对样本（9 岁和 15 岁）扩大到 2200 名样品。我们计划在 2020 年测量完成后提供这些数据。在更新的第一年，延续了 FFCWS 从一开始就标志的服务传统项目中，我们将：目标 1，制定一系列相对较新的措施，包括：a) 多重多基因评分（PGS），包括利用基因表达或实验数据来增强预测能力的几种特定表型，b) 基因注释的 CNV，c) 儿童的表观遗传结构，例如甲基化年龄，甲基化数量性状位点（meQTL）和全表观基因组关联研究（EWAS）得出的总结分数，基于遗传和 DNA 甲基化数据。所有这些衍生措施都将完成并在奖项第一年公开。这些统计数据将为遗传研究提供重要的新工具少数民族人口评估。目标 2，使用多种族阵列对 FFCWS 母亲进行基因分型，允许通过遗传（包括遗传养育）和社会途径。由于最近呼吁扩大基因组，这项工作具有更大的价值对非欧洲血统（特别是非洲和西班牙裔）个人和儿童进行广泛的工作。在目标 3 中，我们探索有关大规模 TL 研究的 DNA 收集、处理和存储的最佳实践，涉及唾液、新鲜血液和储存的新生儿干血斑 (nDBS)。这些实验将有助于达成共识与美国人口协会举行的生物标记网络会议相关的会议。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Characteristics of salivary telomere length shortening in preterm infants.

早产儿唾液端粒长度缩短的特征。

DOI：
发表时间：
2023
期刊：
影响因子：
3.7
作者：
Schneper, Lisa M;Drake, Amanda J;Dunstan, Taylor;Kotenko, Iulia;Notterman, Daniel A;Piyasena, Chinthika
通讯作者：
Piyasena, Chinthika

Telomere Time-Why We Should Treat Biological Age Cautiously.

端粒时间——为什么我们应该谨慎对待生物年龄。