Research Training in Translational Gastroenterology and Hepatology

转化胃肠病学和肝病学研究培训

基本信息

批准号：
10626836
负责人：
SUBRA KUGATHASAN
金额：
$ 36.5万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-01 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10626836
关键词：
Gastroenterology Hepatology Research Training

项目摘要

Project Summary In recent years, major advances in patient care in gastroenterology and hepatology have largely been driven by the application of translationally-oriented research employing animal models and human subjects. Increasingly, cross-pollination of basic and clinical research approaches is producing novel insights into gastrointestinal (GI) and liver biology as well as disease pathogenesis. The over-arching goal of this Training Grant (TG) is to prepare outstanding post-doctoral MD, MD/PhD and PhD researchers for successful and impactful careers in translational gastroenterology and hepatology. The Training Program (TP) emphasizes work at the interface between basic biology and translational medicine in order to fill important gaps in knowledge and develop effective therapeutics. The TP incorporates core goals of embracing diversity, equity and inclusivity at all stages: candidacy outreach, applicant and mentor selection, retention and oversight of trainees, and selected invited speakers. The TP is built upon the strengths of a highly experienced group of 20 NIH-supported trainee-focused mentors (8 from Pediatrics, 9 from Internal Medicine, and 3 from other Departments). The mentor pool consists of 10 of whom are primarily basic researchers, 4 principally clinical researchers, and 6 whose research portfolios are split evenly between basic and clinical research. Since many adult GI and liver diseases have origins in childhood that often continue through life, mentors from both adult and pediatric subspecialties are included. This TG application focuses efforts on enrolling 2 post-doctoral Trainees (MD, MD/PhD or PhD) each year. Trainees develop expertise and provide feedback as digestive health researchers under the oversight and guidance of the TP Executive Committee and mentors, integrating Internal and External Advisory Board input. For those who will benefit from advanced degrees, the TP is incorporates a structured degree program in Masters of Science in Clinical Research or a Certificate Program in Translational Research via the Laney Graduate School/Georgia Clinical and Translational Science Alliance. Mentees benefit from a balanced Scholarship Oversight Committee with basic and translational expertise, coursework for the Responsible Conduct of Research (RCR) training and a mentee-driven Individual Development Plan (IDP). Completion of individualized TP (coursework, mentored research experience, environmental exposure, advice and professional development) within a culture of talks and symposia for education and career development via the Enrichment Program of the TP, provide a rich and lasting springboard for mentees' careers.

项目概要近年来，胃肠病学和肝病学患者护理的重大进展很大程度上是由动物模型和人类受试者的转化型研究的应用推动的。基础和临床研究方法的交叉授粉越来越多地产生了对胃肠道（GI）和肝脏生物学以及疾病发病机制的新见解。该培训补助金 (TG) 的总体目标是为杰出的博士后医学博士、医学博士/博士和博士研究人员做好准备，使其在转化胃肠病学和肝病学领域取得成功和有影响力的职业生涯。培训计划（TP）强调基础生物学和转化医学之间的交叉点，以填补重要的知识空白并开发有效的治疗方法。 TP 纳入了在各个阶段拥抱多样性、公平性和包容性的核心目标：候选人推广、申请人和导师的选择、学员的保留和监督以及选定的受邀演讲者。 TP 建立在由 20 名 NIH 支持的以实习生为中心的导师组成的经验丰富的团队的优势之上（8 名来自儿科，9 名来自内科，3 名来自其他科室）。导师库由 10 名主要是基础研究人员、4 名主要是临床研究人员以及 6 名研究人员在基础研究和临床研究之间平均分配的人员组成。由于许多成人胃肠道和肝脏疾病起源于童年，并且往往持续一生，因此来自成人和儿科亚专业的导师也包括在内。该TG申请的重点是每年招收2名博士后培训生（MD、MD/PhD或PhD）。学员在 TP 执行委员会和导师的监督和指导下，整合内部和外部顾问委员会的意见，作为消化健康研究人员发展专业知识并提供反馈。对于那些将从高级学位中受益的人，TP 包含临床研究理学硕士学位的结构化学位课程或通过莱尼研究生院/佐治亚州临床和转化科学联盟提供的转化研究证书课程。学员受益于平衡的奖学金监督委员会，该委员会拥有基础和转化专业知识、负责任的研究行为（RCR）培训课程以及学员驱动的个人发展计划（IDP）。通过 TP 强化计划，在教育和职业发展的讲座和研讨会文化中完成个性化 TP（课程作业、指导研究经验、环境接触、建议和专业发展），为学员的职业生涯提供丰富而持久的跳板。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

It Takes Two to Make It Right: Dual Biologic and Small Molecule Therapy for Treatment-Refractory Pediatric Inflammatory Bowel Disease.

需要两个方法才能解决问题：双重生物疗法和小分子疗法治疗难治性小儿炎症性肠病。

DOI：
发表时间：
2021
期刊：
影响因子：
4.9
作者：
Geem, Duke;Kugathasan, Subra
通讯作者：
Kugathasan, Subra

Resolution of recurrent pediatric acute liver failure with liver transplantation in a patient with NBAS mutation.

NBAS 突变患者通过肝移植解决复发性小儿急性肝衰竭。

DOI：
发表时间：
2021-11
期刊：
影响因子：
1.3
作者：
Geem, Duke;Jiang, Wenxiao;Rytting, Heather B;Chandrakasan, Shanmuganathan;Salem, Anand;Stevens, James P;Karpen, Saul J;Magliocca, Joseph F;Romero, Rene;Rodriguez, Dellys Soler
通讯作者：
Rodriguez, Dellys Soler

Single-Center Retrospective Review of the Presentation and Initial Care of Esophageal Button Battery Impactions 2007-2020.

2007-2020 年食管纽扣电池嵌塞的表现和初步护理的单中心回顾性审查。

DOI：
发表时间：
2023-04-01
期刊：
影响因子：
1.4
作者：
Sinclair, Elizabeth M;Agarwal, Maneesha;Santore, Matthew T;Sauer, Cary G;Riedesel, Erica L
通讯作者：
Riedesel, Erica L

Comparing Eosinophilic Esophagitis in a Black and Non-Black Pediatric Cohort.

比较黑人和非黑人儿科人群中的嗜酸性粒细胞性食管炎。

DOI：
发表时间：
2022-10-01
期刊：
影响因子：
2.9
作者：
Edwards;Moraczewski, Jason;Offerle, Thomas;Sinclair, Elizabeth M;Xiang, Yijin;Gillespie, Scott;Kruszewski, Patrice
通讯作者：
Kruszewski, Patrice

Advances in treatment of glucocorticoid-induced osteoporosis.

糖皮质激素引起的骨质疏松症的治疗进展。