Center for Skeletal Research (Overall Application)

骨骼研究中心（整体应用）

基本信息

批准号：
10626806
负责人：
Marie Demay
金额：
$ 84.17万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-19 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10626806
关键词：
Advisory Committees Award Biological Assay Biology Boston Cell Separation Cells Clinical Investigator Collaborations Communication Communities Complement Core Facility Country Data Dental Schools Development Diagnosis Diagnostic tests Discipline Disease Educational workshop Effectiveness Endocrine Equity Faculty Feedback Fostering Funding General Hospitals Goals Grant Histologic Histology Human Institution Laboratories Laboratory Research Maine Massachusetts Medicine Mentors Methodology Methods Mus New England Osteoporosis Phenotype Postdoctoral Fellow Protocols documentation Radiology Specialty Rare Diseases Research Research Personnel Resources Sampling Science Scientist Series Services Signal Transduction Site Suggestion System Techniques Travel United States National Institutes of Health Universities Update Work X-Ray Computed Tomography base bone bone cell bone imaging calcium metabolism environmental enrichment for laboratory animals experience innovation medical schools meetings member microCT novel novel diagnostics novel therapeutics phosphorus metabolism posters programs single-cell RNA sequencing skeletal skeletal disorder success symposium tool transcriptome sequencing web site

项目摘要

The overall goal of the Center for Skeletal Research is to foster interdisciplinary and collaborative work that leads to a deeper understanding of skeletal biology and disease. The Center will build upon and expand a community of bone scientists in the Endocrine Unit and other Units at the Massachusetts General Hospital, other Harvard institutions, and Boston University and other institutions in Boston and the broader New England region. These scientists are diverse, including clinical investigators and laboratory investigators using a broad array of approaches from multiple disciplines. The mechanisms that the Center will use to accomplish its goal include Core Facilities, a Pilot and Feasibility Grant Program, and an enrichment program. The Cores will include an Administrative Core, a Skeletal Phenotyping Core and a Bone Cell Analysis Core. These Cores will emphasize the development of new techniques that can drive the science of Center investigators, as well as the provision of expert and efficient service. The services include histology, microCT imaging, human and mouse bone cell isolation, bulk and single cell RNA sequencing of bone, and bone signaling assays. The Administrative Core will direct the research cores, a Pilot and Feasibility Program, and also an enrichment program. The enrichment program will include a monthly seminar series featuring talks by junior investigators of the Center, a methods workshop series, a Pilot and Feasibility Program, an Innovation Awards program (travel awards and mini-grant program), and a yearly Symposium/poster session. The goal of the Pilot and Feasibility Grant Program will be to allow young investigators to develop sufficient data to obtain their own grants; in that context, a vigorous mentoring program will complement the funding. The seminar series will foster collaboration and communication among Center scientists. Young investigators will present current data in some sessions, while others will bring in distinguished bone scientists from outside of Boston to enrich the environment. This series will also include presentations by Core Directors that explain the techniques used in the Cores and will provide a forum for feedback by Center investigators that will include suggestions for novel Core services. An Administrative Core will assure effective functioning of these activities through regular meetings of Core Directors that, four times a year, will also involve meeting with an Advisory Committee made up of senior investigators within the Center, as well as investigators from elsewhere with relevant experience leading similar programs. The Center will be committed to sharing its innovations with the broader community of bone scientists across the country.

骨骼研究中心的总体目标是促进跨学科和协作工作，有助于更深入地了解骨骼生物学和疾病。该中心将建立并扩展马萨诸塞州总医院内分泌科和其他科室的骨科学家群体，其他哈佛大学机构、波士顿大学以及波士顿和更广泛的新英格兰地区的其他机构地区。这些科学家是多种多样的，包括临床研究人员和实验室研究人员，他们使用广泛的来自多个学科的一系列方法。该中心将用来实现其目标的机制包括核心设施、试点和可行性补助计划以及丰富计划。核心将包括管理核心、骨骼表型分析核心和骨细胞分析核心。这些核心将强调新技术的发展，可以推动中心研究人员的科学发展，以及提供专业、高效的服务。服务包括组织学、显微 CT 成像、人体和小鼠骨细胞分离、骨的批量和单细胞 RNA 测序以及骨信号传导测定。这行政核心将指导研究核心、试点和可行性计划以及丰富项目程序。丰富项目将包括每月一次的研讨会系列，由初级研究人员进行演讲中心的一系列方法研讨会、试点和可行性计划、创新奖计划（旅行奖和小额赠款计划），以及每年一次的研讨会/海报会议。试点的目标和可行性资助计划将允许年轻的研究人员开发足够的数据来获得他们自己的数据补助金；在这方面，强有力的指导方案将补充资金。系列研讨会将促进中心科学家之间的合作与交流。年轻的研究人员将展示当前数据在某些会议上，而其他会议将邀请来自波士顿以外的杰出骨骼科学家来丰富环境。本系列还将包括核心董事的演讲，解释在核心，并将提供一个论坛，供中心调查人员提供反馈，其中包括对新颖的建议核心服务。行政核心将通过定期确保这些活动的有效运作核心董事会议每年举行四次，其中还包括与咨询委员会的会议由中心内的高级调查员以及来自其他地方具有相关经验的调查员组成领导类似的计划。该中心将致力于与更广泛的社区分享其创新成果全国各地的骨科学家。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.

赖氨酰氧化酶样 2 可预防小鼠进行性和衰老相关的膝关节骨关节炎。

DOI：
发表时间：
2019-09-27
期刊：
影响因子：
5.6
作者：
Tashkandi, Mustafa;Ali, Faiza;Alsaqer, Saqer;Alhousami, Thabet;Cano, Amparo;Martin, Alberto;Salvador, Fernando;Portillo, Francisco;C Gerstenfeld, Louis;Goldring, Mary B;Bais, Manish V
通讯作者：
Bais, Manish V

A hypomorphic variant in the translocase of the outer mitochondrial membrane complex subunit TOMM7 causes short stature and developmental delay.

线粒体外膜复合物亚基 TOMM7 易位酶的亚等位变异会导致身材矮小和发育迟缓。

DOI：
发表时间：
2023-01-12
期刊：
影响因子：
0
作者：
Young, Cameron;Batkovskyte, Dominyka;Kitamura, Miyuki;Shvedova, Maria;Mihara, Yutaro;Akiba, Jun;Zhou, Wen;Hammarsjö, Anna;Nishimura, Gen;Yatsuga, Shuichi;Grigelioniene, Giedre;Kobayashi, Tatsuya
通讯作者：
Kobayashi, Tatsuya

Impaired 1,25-dihydroxyvitamin D3 action underlies enthesopathy development in the Hyp mouse model of X-linked hypophosphatemia.

1,25-二羟基维生素 D3 作用受损是 X 连锁低磷血症 Hyp 小鼠模型中附着点病发生的基础。

DOI：
发表时间：
2023-09-08
期刊：
影响因子：
8
作者：
Rana, Rakshya;Baker, Jiana T;Sorsby, Melissa;Jagga, Supriya;Venkat, Shreya;Almardini, Shaza;Liu, Eva S
通讯作者：
Liu, Eva S

Impaired Growth Plate Maturation in XLH Is due to Both Excess FGF23 and Decreased 1,25-Dihydroxyvitamin D Signaling.

XLH 生长板成熟受损是由于 FGF23 过量和 1,25-二羟基维生素 D 信号传导减少所致。

DOI：
发表时间：
2023-11-20
期刊：
影响因子：
4.8
作者：
Yadav, Prem Swaroop;Kobelski, Margaret M;Martins, Janaina S;Tao, Tao;Liu, Eva S;Demay, Marie B
通讯作者：
Demay, Marie B

Reversing the miRNA -5p/-3p stoichiometry reveals physiological roles and targets of miR-140 miRNAs.

逆转 miRNA -5p/-3p 化学计量揭示了 miR-140 miRNA 的生理作用和靶标。