Childhood Antecedents of Adult Cardiometabolic health: A Prospective Study of Low-Income Men

成人心脏代谢健康的童年前因：低收入男性的前瞻性研究

基本信息

批准号：
10635802
负责人：
ANNA L MARSLAND
金额：
$ 7.53万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10635802
关键词：
Address Adolescence Adult Age Attenuated Biological Markers Blood Pressure Buffers Cardiometabolic Disease Cardiovascular Diseases Cause of Death Child Childhood Chronic Disease Communities Development Diabetes Mellitus Disadvantaged Disease Dyslipidemias Economic Conditions Economically Deprived Population Epidemiology Family Growth Health Health behavior Immunologic Factors Income Individual Informal Social Control Insulin Resistance Intervention Investigation Knowledge Life Link Longitudinal prospective study Low income Mediating Metabolic Pathway Methods Mothers Neighborhoods Obesity Outcome Pathogenesis Pathway interactions Phase Physiologic pulse Policies Poverty Prevention Prevention program Process Prospective Studies Race Reporting Research Risk Risk Assessment Risk Factors Role Sampling Schools Shapes Stress Testing Toddler Woman aged base boys cardiometabolic risk cardiometabolism cardiovascular disorder risk cardiovascular health carotid intima-media thickness community-level factor disorder risk early childhood emerging adult experience health disparity high risk informant intergenerational intervention program low socioeconomic status lower income families men middle childhood novel parent project physical conditioning pre-clinical prevent programs prospective protective factors recruit resilience socioeconomic adversity socioeconomic disadvantage socioeconomic disparity socioeconomics stem systemic inflammatory response teacher transmission process young man

项目摘要

Project Summary/Abstract Cardiovascular disease (CVD) and diabetes are leading causes of death among adults in the US, with incident disease following years of accumulating risk conferred through various metabolic pathways (obesity, dyslipidemia, insulin resistance), immune factors (e.g., systemic inflammation), and rising blood pressure. The pathogenesis of CVD and cardiometabolic health begins in childhood, thus it is imperative to identify factors that contribute to emerging cardiometabolic health disparities. Like other chronic diseases, CVD and diabetes track a socioeconomic gradient, with greater lifelong health risk among individuals born into disadvantaged circumstances. However, no prospective studies have carefully characterized links between early socioeconomic disadvantage and adult health, addressing whether poverty during particular developmental stages is especially harmful and delineating developmentally salient risk factors that may link economic disadvantage to cardiometabolic disease (CMD) risk. Guided by the family stress framework, we propose that family-, school- and community-level factors during critical phases of development are pathways through which socioeconomic disadvantage in childhood shapes cardiometabolic health. We also consider the role of child- based protective factors that might buffer the effects of poverty on adult health outcomes. Finally, we explore how race and SES intersect to shape risk for CMD in adulthood and whether adult health behaviors are pathways through which economic disadvantage gives rise to greater propensity for CMD. The project will assess the cardiovascular health of a diverse sample of 248 adult men (aged 31-33 years) who participated in the Pittsburgh Mother & Child Project (PMCP). The parent project recruited a sample of 310 toddlers from low income families and has followed them closely to early adulthood, permitting a comprehensive assessment of risk and protective factors. We will consider whether these factors relate to biomarkers of cardiometabolic health risk and preclinical markers of CVD – carotid intima media thickness and pulse wave velocity. By testing novel contextual pathways at the family, school, and neighborhood levels this investigation will help to identify contexts that can be targeted by programs and policies aimed at reducing socioeconomic disparities in adult health.

项目概要/摘要心血管疾病（CVD）和糖尿病是美国成年人死亡的主要原因，经过多年通过各种代谢积累的风险后发生疾病途径（肥胖、血脂异常、胰岛素抵抗）、免疫因素（例如全身性炎症），以及心血管疾病的发病机制和心脏代谢健康。从童年开始，因此必须确定有助于新兴的因素与其他慢性疾病一样，心血管疾病和糖尿病也存在着差异。社会经济梯度，出生于以下国家的个体终生健康风险更大然而，没有前瞻性研究仔细描述不利的情况。早期社会经济劣势与成人健康之间的联系，解决贫困是否在特定的发育阶段尤其有害并且会影响发育可能将经济劣势与心脏代谢疾病（CMD）风险联系起来的显着风险因素。在家庭压力框架的指导下，我们建议家庭、学校和社区层面发展关键阶段的因素是社会经济发展的途径儿童时期的不利影响了心脏代谢健康。可能缓冲贫困对成人健康结果影响的保护因素。最后，我们探讨种族和社会经济地位如何交叉影响成年后 CMD 的风险，以及是否成人健康行为是经济劣势导致更大影响的途径该项目将评估 248 名不同样本的心血管健康状况。参加匹兹堡母婴项目的成年男性（31-33岁） (PMCP) 母项目招募了来自低收入家庭的 310 名幼儿样本。一直密切关注他们直至成年早期，从而可以对风险进行全面评估我们将考虑这些因素是否与生物标志物有关。心脏代谢健康风险和 CVD 的临床前标志物——颈动脉内膜中层厚度通过测试家庭、学校和脉搏波速度。这项调查将有助于确定社区层面的目标环境旨在减少成人健康方面的民主差异的方案和政策。