Administrative Supplements for NIAID Regional Biocontainment Laboratories (RBL)

NIAID 区域生物防护实验室 (RBL) 的行政补充

• 批准号: 10630718
• 负责人: Farhang Alem
• 金额: $ 403.99万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630718
• 关键词: 2019-nCoV; Address; Administrative Supplement; Alphavirus; Animal Diseases; Animal Model; Animals; Applied Research; Award; Basic Science; Biochemistry; Biological Assay; Biology; Biomedical Engineering; Biomedical Research; Bunyaviridae; COVID-19 pandemic; Cells; Chikungunya virus; Clinical; Collaborations; Communicable Diseases; Community Health; Containment; Core Facility; Coronavirus; Development; Diagnostic; Ensure; Epidemic; Evaluation; FDA approved; Faculty; Family; Ferrets; Flaviviridae; Funding; Goals; Government; Histology; Image; Immunomodulators; In Vitro; Infection; Infectious Diseases Research; Infrastructure; Investments; Laboratories; Laboratory Research; Leadership; Methodology; Modernization; Molecular; National Institute of Allergy and Infectious Disease; Orthobunyavirus; PET/CT scan; Parents; Pathogenesis; Pathogenicity; Peer Review; Pharmaceutical Preparations; Population; Publishing; Rapid screening; Readiness; Reagent; Reporter; Research; Research Personnel; Rodent; Sampling; Security; Seeds; Sterilization; Students; System; Systems Analysis; Systems Biology; Talents; Technology; Therapeutic; Togaviridae; Universities; Vaccines; Venezuelan Equine Encephalitis Virus; Virus; Water; Western Equine Encephalitis Virus; advanced system; animal imaging; animal tissue; arm; base; cellular imaging; combat; extracellular vesicles; global health; human disease; imager; improved; in vivo; industry partner; innovation; instrument; instrumentation; member; multiple omics; neutralizing antibody; novel; operation; pandemic disease; pandemic preparedness; particle; pathogenic bacteria; pathogenic virus; pre-clinical; programs; recruit; research and development; sequencing platform; small molecule; technology development; therapeutic candidate; therapeutic development; tissue processing; transcriptomics; vaccine candidate; vaccine development

Project Summary/Abstract: The ongoing COVID pandemic has demonstrated the need for state-of-the-art facilities and infrastructure to improve our preparedness for subsequent epidemics and/or pandemics. George Mason University (GMU), leveraging the Regional Biocontainment Laboratory, designated as the Biomedical Research Laboratory (BRL), has established a biomedical research program with a strong emphasis on newly emerging and re- emerging viral and bacterial pathogens with the potential to cause severe human and animal diseases. The specific viral pathogen families of greatest pandemic concern currently investigated in the BRL are: Togaviridae, Bunyaviridae, Coronaviridae, and Flaviviridae. Several faculty members in five departments at GMU (Systems Biology, Biology, Bioengineering, Biochemistry, and Global and Community Health) as well as external collaborators conduct research on basic and applied research to include pathogenicity, infection mechanisms, and development of diagnostics, vaccines and therapeutics. The infectious disease portfolio at GMU was $8.8 million in FY21 and is expected to grow by at least 3X in the next five years. To realize this goal, GMU leadership is making aggressive, strategic investments in new faculty hires and seed funding, as well as creating broader access to the BRL. More than 244 peer-reviewed articles on infectious diseases research have been published by GMU investigators since 2010. The BRL staff is dedicated to supporting GMU faculty, students, and their collaborators to develop new translational solutions for pandemic preparedness. Research with translational promise includes 1) development of additional vaccine candidates that confer broad-spectrum protection against multiple strains of alphaviruses or coronaviruses, 2) evaluation of host-based therapeutics that have demonstrated in vitro broad- spectrum efficacy against alphaviruses (VEEV, EEEV, WEEV, CHIKV), bunyaviruses (RVFV) and coronaviruses (SARS-CoV-2) in rodent and nonrodent animal models including ferrets, and 3) development of new platform technologies including extracellular vesicle (EV)-based immunomodulators and reporter viruses that can facilitate rapid screening of clinical and nonclinical samples for neutralizing antibodies. Our high containment facility supported by a team of operations and technical staff, creates opportunities for a broad base of internal and external investigators to conduct in vitro and in vivo research and development on newly emerging and re-emerging viral and bacterial pathogens. GMU is requesting funds to supplement the funded G20 parent award, “Facility and Building System Upgrades Support for the Mason Biomedical Research Laboratory” to resolve additional specific instrumentation and facility gaps that will support the creation of a modern, comprehensive, agile and resilient preclinical biomedical research pipeline to address national and global pandemic preparedness.

项目摘要/摘要： 持续的新冠疫情表明需要最先进的设施和基础设施 提高我们对随后的流行病和/或大流行病的准备程度 乔治梅森大学 (GMU)， 利用被指定为生物医学研究实验室的区域生物防护实验室 （BRL），建立了一个生物医学研究计划，重点关注新兴和重新开发的生物医学研究计划。 新出现的病毒和细菌病原体有可能引起严重的人类和动物疾病。 目前 BRL 中调查的最受大流行关注的特定病毒病原体家族是： 披膜病毒科、布尼亚病毒科、冠状病毒科和黄病毒科的几位教员。 GMU（系统生物学、生物学、生物工程、生物化学以及全球和社区健康）以及 外部合作者进行基础和应用研究，包括致病性、感染性 机制以及诊断、疫苗和治疗方法的开发。 2021 财年，GMU 的传染病投资组合为 880 万美元，预计本财年将增长至少 3 倍 为了实现这一目标，GMU 领导层正在对新教师进行积极的战略投资。 招聘和种子资金，以及创建更广泛的 BRL 访问权限 超过 244 篇同行评审文章。 自 2010 年起，GMU 研究人员就发表了关于传染病研究的论文。 BRL 员工致力于支持 GMU 教师、学生及其合作者开发新的 具有转化前景的研究包括 1) 开发其他候选疫苗，可针对多种菌株提供广谱保护 甲病毒或冠状病毒，2）评估已在体外广泛证明的基于宿主的疗法 针对甲病毒（VEEV、EEEV、WEEV、CHIKV）、布尼亚病毒（RVFV）和 啮齿类和非啮齿类动物模型（包括雪貂）中的冠状病毒（SARS-CoV-2），以及 3） 新平台技术，包括基于细胞外囊泡（EV）的免疫调节剂和报告病毒 有助于快速筛选临床和非临床样本中的中和抗体。 我们的高密闭设施由运营和技术人员团队支持，为 广泛的内部和外部研究人员基础进行体外和体内研究和开发 新出现和重新出现的病毒和细菌病原体正在申请资金来补充。 资助 G20 家长奖“为梅森生物医学中心提供设施和建筑系统升级支持” “研究实验室”旨在解决其他特定仪器和设施的差距，以支持 创建现代、全面、敏捷和有弹性的临床前生物医学研究管道，以解决 国家和全球大流行病防范。