Characterizing Cannabis Use and its Impact on Smoking Cessation Among Socioeconomically Disadvantaged Adults Participating in Smoking Cessation Treatment

参与戒烟治疗的社会经济弱势成年人的大麻使用特征及其对戒烟的影响

• 批准号: 10629665
• 负责人: Darla Elizabeth Kendzor
• 金额: $ 5万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629665
• 关键词: Abstinence; Address; Administrative Supplement; Adult; Alcohol consumption; Cancer Etiology; Cannabis; Carbon Monoxide; Cellular Phone; Cessation of life; Characteristics; Cigarette; Cigarette Smoker; Collaborations; Data; Dependence; Distal; Enrollment; Exposure to; Frequencies; Goals; Incidence; Income; Intervention; Intervention Trial; Knowledge; Legal; Low income; Malignant Neoplasms; Malignant neoplasm of lung; Marijuana Dependence; Marijuana Smoking; Mental Health; Modality; Nicotine Withdrawal; Outcome; Parents; Participant; Patient Self-Report; Pattern; Perception; Positioning Attribute; Prevalence; Psyche structure; Recording of previous events; Reporting; Research; Research Personnel; Respiratory Signs and Symptoms; Risk; Schedule; Severities; Smoke; Smoker; Smoking; Smoking Cessation Intervention; Time; Tobacco; Tobacco use; Tobacco-Related Carcinoma; Treatment outcome; Withdrawal Symptom; base; cigarette craving; cigarette smoking; diaries; follow up assessment; follow-up; improved; interest; low socioeconomic status; marijuana use; marijuana user; mortality; non-smoker; physical conditioning; respiratory health; response; secondhand cannabis smoke; smartphone based assessment; smoking abstinence; smoking cessation; smoking prevalence; smoking-related cancer; sociodemographics; socioeconomic disadvantage; success; tobacco cessation intervention

This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT- CA-22-070, Administrative Supplements for Examining Patterns of Tobacco and Cannabis Use. The prevalence of cannabis use is elevated among adults who smoke, and particularly among those with low socioeconomic status. However, the impact of cannabis use on smoking cessation remains unclear. The proposed administrative supplement will leverage an ongoing smoking cessation intervention trial for low-income adult smokers (R01CA251451) to collect new data to characterize baseline and daily cannabis and tobacco use and co-use patterns, compare cannabis users and non-users on respiratory symptoms and mental/physical health, and evaluate the impact of cannabis use on daily smoking and point prevalence smoking abstinence at post-quit follow-up. Data from 135 adults enrolled in the ongoing parent trial will be included in the proposed analyses, to be completed within the 1-year supplement time frame. All participants will provide information about their tobacco and cannabis use at baseline, prior to initiating smoking cessation treatment, and they will complete smartphone-based assessments of their expired carbon monoxide (CO), self-reported tobacco and cannabis use, and other relevant factors over a 7-week period (1- week pre-quit day through 4 weeks post-quit, and during post-quit weeks 8 and 12). Follow-up assessments of CO- verified 7-day point prevalence smoking abstinence will focus on follow-ups at 4, 8, and 12 weeks post-quit to fit within the 1-year supplement time frame. The supplement will address the following specific aims: 1) Characterize cannabis use characteristics among low-income adults participating in tobacco cessation treatment, including a) baseline and daily prevalence, frequency, intensity, and modalities of cannabis use (e.g., combusted vs. non-combusted) as well as reasons for use, b) baseline cannabis dependence severity and harm perceptions, c) daily prevalence of tobacco and cannabis co-use assessed via smartphone-based daily diaries, and d) interest at baseline and follow-up in reducing or abstaining from cannabis use; 2) At baseline, compare past 30-day cannabis users with non-users on sociodemographic characteristics, tobacco use history, physical and mental health, alcohol use, respiratory symptoms, exposure to cannabis secondhand smoke, expired CO levels, and cigarette dependence; 3) Evaluate the within-day and distal relationships between cannabis use and smoking cessation, including: a) the relation between baseline cannabis use (past 30-day use vs. non-use) and smoking cessation outcomes at follow-up (4, 8, and 12 weeks post-quit), b) the within-day relations of cannabis use with cigarette craving, withdrawal symptom severity, and smoking during the weeks following a scheduled quit attempt via smartphone-based assessments, and c) the relation of cannabis use frequency (i.e., near daily use, days of use) during the first 4 weeks following a scheduled smoking quit attempt with CO-verified point prevalence smoking abstinence at follow-ups. Findings will yield important information about the impact of cannabis use during smoking cessation treatment, and identify factors that can be targeted in cessation interventions.

本申请是为了响应被确定为 NOT- 的特殊利益通知 (NOSI) 而提交的 CA-22-070，检查烟草和大麻使用模式的行政补充。患病率 吸烟的成年人，尤其是社会经济地位较低的成年人，大麻的使用率较高。 然而，使用大麻对戒烟的影响仍不清楚。拟议的行政 补充剂将利用针对低收入成年吸烟者正在进行的戒烟干预试验 （R01CA251451）收集新数据来描述基线和日常大麻和烟草使用和共同使用模式， 比较大麻使用者和非使用者的呼吸道症状和心理/身体健康，并评估其影响 大麻使用对日常吸烟的影响以及戒烟后随访中戒烟的点流行率。数据来自135 参加正在进行的家长试验的成年人将被纳入拟议的分析中，该分析将在 1 年内完成 补充时间范围。所有参与者都将提供有关他们在基线、之前使用烟草和大麻的信息 开始戒烟治疗，他们将完成基于智能手机的过期评估 一氧化碳 (CO)、自我报告的烟草和大麻使用情况以及 7 周内的其他相关因素 (1- 戒烟前一周至戒烟后 4 周，以及戒烟后第 8 周和第 12 周）。 CO 的后续评估 经验证的 7 天点戒烟率将重点关注戒烟后 4、8 和 12 周的随访，以适应戒烟情况 1年的补充期限。该增刊将解决以下具体目标：1）描述大麻的特征 参与戒烟治疗的低收入成年人的使用特征，包括 a) 基线和 大麻使用的每日流行率、频率、强度和方式（例如，燃烧与非燃烧）以及 使用原因，b) 基线大麻依赖严重程度和危害认知，c) 烟草和烟草的日常流行率 通过基于智能手机的每日日记评估大麻共同使用，以及 d) 基线兴趣和后续减少或 戒除大麻； 2) 在基线上，将过去 30 天的大麻使用者与非使用者进行比较 社会人口特征、吸烟史、身心健康、饮酒、呼吸系统 症状、接触大麻二手烟、过期一氧化碳水平和香烟依赖； 3）评估 大麻使用与戒烟之间的日内和远端关系，包括： a) 大麻使用基线（过去 30 天使用与不使用）和随访时的戒烟结果（4、8 和 12 戒烟后几周），b）吸食大麻与对香烟的渴望、戒断症状严重程度的日内关系，以及 通过基于智能手机的评估，在计划戒烟尝试后的几周内吸烟，以及 c) 关系 计划吸烟后前 4 周内大麻使用频率（即接近每天使用、使用天数） 随访时通过共同验证的戒烟流行率进行戒烟尝试。研究结果将产生重要成果 有关戒烟治疗期间使用大麻的影响的信息，并确定可影响戒烟治疗的因素 戒烟干预的目标。