Improvements to the Regional Biocontainment Research Facilities at the University of Missouri

密苏里大学区域生物防护研究设施的改进

• 批准号: 10631453
• 负责人: Christian L. Lorson
• 金额: $ 234.07万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631453
• 关键词: 2019-nCoV; Aerosols; Animal Experimentation; Animals; Communities; Containment; Contracts; Decontamination; Emerging Communicable Diseases; Equipment; Faculty; Family suidae; Funding; Goals; Grant; Hepatitis B Virus; Housing; Human; Infection; Infectious Diseases Research; Laboratories; Missouri; National Institute of Allergy and Infectious Disease; Parents; Principal Investigator; Research; Research Personnel; Rodent; Secure; Services; Students; System; Translational Research; United States National Institutes of Health; Universities; biocontainment facility; biodefense; human pathogen; influenzavirus; pathogenic virus; research facility; respiratory virus; whole animal imaging

The objective of the parent G20 grant is to provide state of the art, highly safe and secure biocontainment facilities and services to faculty, student and staff researchers at the MU Laboratory for Infectious Diseases, one of 12 NIH/NIAID Regional Biocontainment Laboratories. The LIDR/MURBL is currently host to more than 60 researchers. Our research community is successful in grant funding with 14 Principal Investigators currently active in federally and privately funded grants/contracts. The current ABSL3 facility supports aerosol challenge of rodents, but larger animal challenges cannot occur due to a lack of appropriate containment housing. The goal of this G20 supplement project is to expand the capabilities of the MURBL to serve the biodefense and emerging infectious disease research for the region. Towards this objective, we propose to renovate the east suite of the ABSL3, including the installation of a specialized ante room and effluent decontamination system, to allow for the housing of large animals in biocontainment. These upgrades would serve the immediate needs of MU faculty of the RBL who are conducting translational research on SARS-CoV-2, influenza virus, and hepatitis B virus. Aim 1: Add open caging capabilities to the ABSL3 at LIDR for housing swine and other large animals following challenge with respiratory viruses that are pathogenic to humans. We propose to build open caging capacity in the ABSL3 at LIDR for housing up to 10 pigs or other large animals that have been experimentally infected with various human pathogens. The request includes funds for remodeling in the anteroom as well as the animal holding room/building effluent system to permit effluent decontamination, and necessary HVAC upgrades. Aim 2: Purchase and install equipment for whole animal imaging following infection. We propose to add capabilities for whole animal imaging, which will allow for reduction of research animals used at LIDR.

母公司 G20 赠款的目标是提供最先进、高度安全的 密苏里大学实验室为教职员工、学生和研究人员提供的生物防护设施和服务 传染病，NIH/NIAID 12 个区域生物防护实验室之一。 LIDR/MURBL 是 目前拥有 60 多名研究人员。我们的研究团体成功提供了 14 项资助 首席研究员目前活跃于联邦和私人资助的赠款/合同领域。目前的ABSL3 设施支持啮齿类动物的气溶胶挑战，但由于缺乏 适当的安全壳。该 G20 补充项目的目标是扩展 MURBL 为该地区的生物防御和新发传染病研究提供服务。朝这个方向 为了实现这一目标，我们建议翻新ABSL3的东侧套房，包括安装专门的 前厅和污水净化系统，以便在生物防护中容纳大型动物。 这些升级将满足 RBL 的 MU 教师的迫切需求，他们正在开展 SARS-CoV-2、流感病毒和乙型肝炎病毒的转化研究。 目标 1：为 LIDR 的 ABSL3 添加开放式笼养功能，用于饲养猪和其他大型动物 在受到对人类致病的呼吸道病毒的挑战后。我们建议建立开放 LIDR 的 ABSL3 的笼养能力可容纳多达 10 头猪或其他大型动物 实验上感染了各种人类病原体。该请求包括用于改造的资金 接待室以及动物饲养室/建筑污水系统，以进行污水净化，以及 必要的暖通空调升级。 目标 2：购买并安装感染后进行整体动物成像的设备。我们建议添加 整个动物成像的能力，这将减少 LIDR 使用的研究动物。