Sterilization Improvement Grant

灭菌改进补助金

• 批准号: 9120170
• 负责人: Patrick J. Sinko
• 金额: $ 49万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-10 至 2018-08-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9120170
• 关键词: Affect; Animal Experimentation; Biomedical Engineering; Decontamination; Dimensions; Ensure; Equipment; Expenditure; Funding; Future; Grant; Location; Modeling; New Jersey; Pharmacy Schools; Principal Investigator; Public Health Schools; Research; Research Infrastructure; Research Personnel; Resources; Rodent; Savings; Security; Side; Sterilization; Time; United States National Institutes of Health; Universities; Wood material; animal care; biosecurity; cost; improved; medical schools; meetings; operation; square foot; trafficking

 DESCRIPTION (provided by applicant): Rutgers, The State University of New Jersey (RU)-Office of Research Advancement (ORAd) requests funds to purchase and outfit a new bulk sterilizer so current as well as future expanding numbers of rodent cages in the Research Tower (RT) Animal Care Facility (ACF) on the Busch campus in Piscataway can be efficiently and effectively sterilized. The RT currently has two sterilizers (Amsco and Steris). Although both are low profile, they are old and have significant serviceability and throughput limitations. In fact, he Amsco sterilizer is in nearly non-operable condition and must be immediately replaced. In addition, neither of the current sterilizers is able to sterilize racks. Without the requested equipment, RU Principal Investigators (PIs) will continue to be challenged to maintain existing barrier rodent colonies or expand these colonies to meet future needs. NIH-funded animal research in RT-ACF will be significantly affected. The proposed new sterilizer has more than three times the capacity of the existing Amsco sterilizer proposed for replacement and will enable significantly faster sterilization of rodent racks, cages and associated equipment than the current model. The location of this new sterilizer will also allow it to serve a dual purpose, allowing decontamination of dirty racks when loaded from the Dirty Cage Wash side while providing sterilization of clean racks when used from the Clean Cage Wash side. Replacing the existing Amsco sterilizer will also enable us to reverse the dirty and clean cage wash to improve traffic flow as well as enhance biosecurity. Additional environmental savings in resources would likewise occur with the purchase of the requested rack/cage sterilizer. Although the ACF in the nearby School of Public Health Building (SPH) has a bulk sterilizer, logistical distance, bio-security and more importantly, a heavy sterilization load at the SPH-ACF precludes the RT-ACF from sending cages to the SPH-ACF for routine sterilization. Replacing outdated, poorly functional equipment at the RT-ACF with a new bulk sterilizer will greatly enhance ORAd's ability to support current NIH-funded Robert Wood Johnson Medical School (RWJMS) investigators as well as eventually allow for a consolidation of PIs from the Schools of Pharmacy (SOP) and Biomedical Engineering (BME) to the RT-ACF. Reducing the number of satellite ACFs will greatly reduce ORAd's operating costs and reduce the per diem burden on PIs and NIH. This equipment plus 2587 square feet (SF) space and supporting infrastructure upgrade fits existing facility dimensions, and utilizes most of the existing infrastructure. To ensure equipment operation Rutgers University will pay any additional expenditure in addition to that requested in this grant. Without a new bulk sterilizer in the short term, the RT-ACF may not meet the rodent needs of RU PIs so they can properly conduct NIH funded research.

 描述（由适用提供）：Rutgers，新泽西州立大学（RU） - 研究进步（ORAD）要求资金购买并适合新的体积消毒剂，因此，研究塔（RT）动物护理设施（ACF）在Busch校园内的PISCATAWAWER中的研究塔（RT）动物护理设施（ACF）的啮齿动物笼子的未来数量可以有效地效率，并有效地效率化。 RT目前有两个灭菌器（AMSCO和Steris）。尽管两者都是低调的，但它们是旧的，并且具有明显的服务性和吞吐量的限制。实际上，他的AMSCO灭菌剂几乎无法解决，必须立即更换。此外，当前的灭菌器都无法刻板印象架。如果没有要求的设备，RU首席调查人员（PIS）将继续受到挑战，以维持现有的障碍啮齿动物殖民地或扩大这些殖民地以满足未来的需求。 NIH资助的RT-ACF动物研究将受到重大影响。拟议的新灭菌剂具有用于替换的现有AMSCO灭菌剂的容量的三倍以上，并且将使啮齿动物架，笼子和相关设备的灭菌速度明显更快。这种新的灭菌器的位置还可以使其达到双重目的，从脏笼式洗涤侧装载时，可以净化肮脏的架子，同时从干净的笼式洗涤侧使用清洁架子。替换现有的AMSCO灭菌器还将使我们能够扭转肮脏和清洁的笼子清洗，以改善交通流量并增强生物安全性。购买所需的架子/笼灭害仪也会发生其他环境节省的资源。尽管公共卫生大楼（SPH）的ACF具有批量的灭菌，后勤距离，生物安全性，更重要的是，SPH-ACF的大量灭菌负荷阻止RT-ACF从将笼子发送到SPH-ACF进行常规灭菌。用新的散装灭菌器代替RT-ACF的过时，功能不佳的设备将增强Orad支持当前NIH资助的Robert Wood Johnson医学院（RWJMS）的研究人员的能力，并最终允许PIS巩固药房（SOP）和Biomedical Engineering（BME）（BME）。减少卫星ACF的数量将大大降低Orad的运营成本，并减少PIS和NIH上的Diem烧伤。该设备加上2587平方英尺（SF）空间和支持基础设施升级适合现有设施尺寸，并利用大多数现有基础架构。为了确保设备操作运营，罗格斯大学还将支付任何其他支出，除了本赠款中要求的支出。在短期内，如果没有新的散装灭菌剂，RT-ACF可能无法满足RU PIS的啮齿动物需求，因此他们可以正确地进行NIH资助的研究。