Portable automated device for rapid venous blood draws and point of care diagnostic analysis
用于快速静脉抽血和护理点诊断分析的便携式自动化设备
基本信息
- 批准号:9145737
- 负责人:
- 金额:$ 69.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-20 至 2019-05-31
- 项目状态:已结题
- 来源:
- 关键词:Accident and Emergency departmentAccountingAddressAdultAmbulatory CareAreaBedside TestingsBiological AssayBloodBlood CellsBlood CirculationBlood PlateletsBlood TestsBlood VolumeBlood capillariesBlood specimenCardiacCaringCellsChildhoodClinicalCollaborationsCollectionComputer softwareCoupledCytometryDetectionDevelopmentDevicesDiagnosticDisciplineElderlyElectronicsElementsEmergency CareEmergency MedicineEmergency SituationEngineeringEnsureFlow CytometryGlassGoalsHealthHematologyHospitalsHumanImageImmunoassayImmunochemistryIn VitroInfantLaboratoriesLifeLiquid substanceManualsMeasurementMedicalMedicineMethodsMicrofabricationMicrofluidic MicrochipsMicrofluidicsMilitary PersonnelNeedlesNeonatalOpticsOutcomeOutpatientsPatient CarePatientsPlasma ProteinsProceduresProcessProtein AnalysisProteinsPumpQuality of CareReagentRecording of previous eventsResearchResourcesRobotRoboticsSafetySamplingSiteSpecimenStreamSupervisionSystemTechniquesTechnologyTest ResultTestingTimeTranslatingTranslationsTroponinUnited StatesUniversity HospitalsValidationVeinsVenipuncturesVenousVenous blood samplingWhole BloodWood materialbaseblood fractionationcostdesigndiagnostic accuracyengineering designhealth care deliveryimage guidedimaging platforminstrumentinterestoptical imagingpoint of carepoint-of-care diagnosticsprogramsprototyperesearch clinical testingresponsesample collection
项目摘要
DESCRIPTION: Diagnostic blood testing is the most ubiquitous clinical procedure in the US, with over 1 billion tests performed annually. The traditional method of blood testing involves performing a venipuncture, transporting samples to a centralized lab, analyzing the samples using large benchtop instruments, and relaying the results to the clinician. This is a labor intensive, time consuming, and expensive process, and unexpected delays often arise due either to difficulties in performing the venipuncture or the time needed to transport and analyze the sample. Particularly in the hospital emergency department (ED), rapid changes in a patient's condition necessitate immediate response, and thus delays can be life threatening. Point of care (PoC) blood testing has emerged as a way to potentially reduce turnaround times, and several devices based on capillary blood draws have achieved commercial translation. However, in comparison to centralized testing, the quantity of available assays remains limited for existing PoC testing, and the accuracy of results obtained with capillary blood remains controversial. Venous blood draws via a venipuncture allows for the collection of a larger volume of blood, yielding more dependable results as the specimen comes directly from the circulation. However to date, no fully automated venous access devices are available, either as independent units, or coupled with POC testing platforms. To address these current limitations, our group is developing a portable, automated device that performs venipuncture and provides quantitative diagnostic results in 15 to 30 minutes at the point of patient care. The portable device will operate by imaging a patient's veins, autonomously introducing a needle into a selected vein, drawing blood into microfluidics chips, and performing on-board blood analysis via an integrated optical imaging platform. A single device will be able to support the throughput of most emergency departments; in this way, the proposed device would serve as an all-in-one portable STAT lab for rapid, automated emergency diagnostics. Outside of emergency medicine, the device could furthermore have strong impact in areas such as ambulatory and outpatient facilities, pediatric and geriatric care, as well as military use.
描述:诊断血液检测是美国最普遍的临床程序,每年进行超过 10 亿次检测。传统的血液检测方法包括进行静脉穿刺、将样本运送到集中实验室、使用大型台式仪器分析样本,以及进行血液检测。将结果转发给临床医生是一个劳动密集型、耗时且昂贵的过程,并且由于进行静脉穿刺的困难或运输和分析样本所需的时间,经常会出现意外的延误。特别是在医院急诊科 (ED),患者病情的快速变化需要立即做出反应,因此延误可能会危及生命。护理点 (PoC) 血液检测已成为一种可能缩短周转时间的方法,并且有多种设备。然而,与集中测试相比,现有的 PoC 测试可用的检测数量仍然有限,并且通过静脉抽血获得的结果的准确性仍然存在争议。静脉穿刺可以采集更多的血液,由于样本直接来自循环系统,因此可以产生更多的相关结果。然而,迄今为止,还没有完全自动化的静脉接入设备,无论是作为独立的单元,还是与 POC 测试平台结合使用。为了解决当前的这些限制,我们的团队正在开发一种便携式自动化设备,可以在患者护理时进行静脉穿刺并在 15 至 30 分钟内提供定量诊断结果。该便携式设备将通过对患者的静脉进行成像来进行操作。拟议的方案是,将针头自动插入选定的静脉,将血液吸入微流体芯片,并通过集成光学成像平台进行机载血液分析。该设备将作为一个一体化便携式 STAT 实验室,用于快速、自动化的紧急诊断,除了急诊医学之外,该设备还可以在门诊和门诊设施、儿科和老年护理以及军事等领域产生强大的影响。使用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Martin L Yarmush其他文献
Martin L Yarmush的其他文献
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{{ truncateString('Martin L Yarmush', 18)}}的其他基金
Merging Innovation, Translational Medicine, and Entrepreneurship in Biomedical En
融合生物医学领域的创新、转化医学和创业精神
- 批准号:
8471108 - 财政年份:2012
- 资助金额:
$ 69.63万 - 项目类别:
Merging Innovation, Translational Medicine, and Entrepreneurship in Biomedical En
融合生物医学领域的创新、转化医学和创业精神
- 批准号:
8265155 - 财政年份:2012
- 资助金额:
$ 69.63万 - 项目类别:
Merging Innovation, Translational Medicine, and Entrepreneurship in Biomedical En
融合生物医学领域的创新、转化医学和创业精神
- 批准号:
8726984 - 财政年份:2012
- 资助金额:
$ 69.63万 - 项目类别:
Merging Innovation, Translational Medicine, and Entrepreneurship in Biomedical En
融合生物医学领域的创新、转化医学和创业精神
- 批准号:
9134519 - 财政年份:2012
- 资助金额:
$ 69.63万 - 项目类别:
Cellular Composite Device for Combination Therapy of Acute Liver Failure
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- 批准号:
7771273 - 财政年份:2010
- 资助金额:
$ 69.63万 - 项目类别:
Cellular Composite Device for Combination Therapy of Acute Liver Failure
用于急性肝衰竭联合治疗的细胞复合装置
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8063890 - 财政年份:2010
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Extended Storage of Tissues and Organs in Subzero Environments
组织和器官在零度以下环境中的长期储存
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8231028 - 财政年份:2009
- 资助金额:
$ 69.63万 - 项目类别:
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