Direct Deposition of Polymer Fibers for Use as a Surgical Sealant

直接沉积聚合物纤维用作手术密封剂

• 批准号: 9027181
• 负责人: PETER KOFINAS
• 金额: $ 37.28万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2019-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9027181
• 关键词: Acute; Address; Adhesions; Adhesives; Anastomosis - action; Animals; Architecture; Behavior; Biocompatible Materials; Biological Assay; Body Temperature; Body Weight Changes; Cell Survival; Chemicals; Chemistry; Child; Childhood; Chronic; Clinical; Clinical Treatment; Complication; Deposition; Development; Differential Scanning Calorimetry; Exhibits; Extravasation; Family suidae; Fiber; Fibrin; Gases; Gel Chromatography; Generations; Glutaral; Glycolates; Goals; Hemostatic Agents; Hydrogels; Hydrophobicity; Implant; In Vitro; Inflammatory Response; Institutes; Intestines; Intramuscular; Investigation; Laboratories; Lead; Longevity; Maryland; Measurement; Mechanics; Medical; Modeling; Modification; Molecular Weight; Monitor; Morbidity - disease rate; Morphology; Mus; Operative Surgical Procedures; Outcome; Phase; Polymers; Pre-Clinical Model; Preparation; Procedures; Process; Property; Research; Risk; Safety; Scanning Electron Microscopy; Skin; Source; Spectrum Analysis; Speed; Surface; Surgical incisions; Swelling; Techniques; Technology; Testing; Tissues; Toxic effect; Transmission Electron Microscopy; Traumatic injury; Universities; Water; Work; absorption; base; biodegradable polymer; biomaterial compatibility; clinical application; clinical efficacy; cost; design; disease transmission; ethylene glycol; hydrophilicity; improved; in vivo; in vivo Model; innovation; insight; mortality; pre-clinical; pressure; public health relevance; scaffold; seal; surgery material; tissue reconstruction; tissue repair; tool; wound

 DESCRIPTION (provided by applicant): Tissue reconstruction and closure of incisions and wounds is pertinent to almost all surgical interventions and traumatic injuries. This project aims to develop a medical sealant that reduces cost, inflammatory response and disease transmission risk, while improving procedural outcomes. Current clinical options suffer from a combination of high cost, poor material properties, and biocompatibility issues. Utilizing a technique called solution blow spinning, polymer fibers can be deposited directly onto any surface. Solution blow spinning has the potential to be a powerful tool in surgery and in biomaterials fabrication. The overall objective of this proposal is to investigate the use of solution blow spun polymer blends of poly(ethylene glycol) (PEG) and poly(lactic-co-glycolic acid) (PLGA) for use as a surgical sealant in an intestinal anastomosis model. The hypothesis for this research is: solution blow spun PLGA/PEG blends will have advantages over existing sealant strategies, leading to better surgical procedure outcomes. This proposal has been designed to utilize the complementary expertise and facilities at the University of Maryland's Functional Macromolecular Laboratory (UMD) and the Sheikh Zayed Institute for Pediatric Surgical Innovation at Children's National. The Specific Aims of the proposed research are: 1. Adhesive optimization, characterization, and in vitro assessment 2. Polymer functionalization for improved adhesion and in vitro characterization 3. In vivo pre- clinical efficacy and biocompatibility of blow spun polymer sealants in acute and chronic pre-clinical models. This work aims to correlate material properties and deposition conditions to in vitro and in vivo efficacy, and will lead to greater insight into the development of effective surgical materials. Ultimately, successful development of the direct deposition of polymer fiber constructs using solution blow spinning onto any surface could lead to clinically translatable approaches in a diverse variety of surgical applications and in biomaterials fabrication.

 描述（由申请人提供）：组织重建以及切口和伤口的闭合几乎与所有外科手术和创伤性损伤相关。该项目旨在开发一种医用密封剂，可降低成本、炎症反应和疾病传播风险，同时改善手术结果。目前的临床选择面临着成本高、材料性能差和生物相容性问题的困扰，利用溶液吹纺技术，聚合物纤维可以直接沉积到任何表面上，有可能成为一种强大的工具。该提案的总体目标是研究聚乙二醇（PEG）和聚乳酸乙醇酸（PLGA）的溶液吹纺聚合物混合物在外科手术中的应用。这项研究的假设是：溶液吹纺 PLGA/PEG 混合物将比现有的密封剂策略具有优势，从而获得更好的手术结果。该提案旨在利用互补的专业知识和设施。马里兰大学功能大分子实验室 (UMD) 和国家儿童医院谢赫扎耶德儿科外科创新研究所的具体目标是： 1. 粘合剂优化、表征和体外评估 2. 聚合物功能化以提高粘合力和稳定性体外表征 3. 吹纺聚合物密封剂在急性和慢性临床前模型中的体内临床前功效和生物相容性。材料特性和沉积条件对体外和体内功效的影响，并将导致对有效手术材料开发的更深入了解，最终，使用溶液吹纺在任何表面上直接沉积聚合物纤维结构的成功开发可能会导致临床应用。在各种外科应用和生物材料制造中可转化的方法。