Sedentary Behavior and Cardiovascular Health in Young Women

年轻女性的久坐行为与心血管健康

基本信息

批准号：
10623317
负责人：
Bethany Barone Gibbs
金额：
$ 60.65万
依托单位：
WEST VIRGINIA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-20 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10623317
关键词：
Acceleration Accelerometer Activity Cycles Acute Address Adverse event Age Ancillary Study Autonomic Dysfunction Behavior Behavior Therapy Behavior assessment Behavioral Blood Pressure Body mass index Calibration Cardiac health Cardiovascular Diseases Cardiovascular system Cholesterol Clinical Data Development Disease Outcome Epidemiology Exposure to Female Glucose Guidelines High Risk Woman Indiana Intervention Laboratories Leisures Life Style Link Lipids Longitudinal cohort Measurement Measures Modality Monitor Mothers Nature Nulliparity Outcome Study Patient Self-Report Pattern Persons Physical activity Physiologic pulse Posture Pregnancy Pregnancy Outcome Recommendation Recording of previous events Reporting Research Resources Risk Risk Factors Role Self Correction Sex Differences Statistical Methods Sum Testing Thigh structure Time United States National Institutes of Health Woman adverse pregnancy outcome arterial stiffness behavior measurement blood pressure elevation cardiovascular disorder prevention cardiovascular disorder risk cardiovascular health cardiovascular risk factor clinical development cohort critical period design fasting glucose heart rate variability high risk high risk population improved innovation light intensity men middle age modifiable risk novel novel strategies post pregnancy prospective response sedentary lifestyle sex standard measure therapy development vigorous intensity young adult young woman

项目摘要

ABSTRACT Women have more rapid cardiovascular disease (CVD) risk development compared to men during young adulthood; yet, little research has studied factors that could curtail CVD risk development during this critical period for young women. The Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-Be Heart Health Study (nuMoM2b HHS) is a unique, multi-center, longitudinal cohort, originating during the first pregnancy, that is now studying associations between adverse pregnancy outcomes (APO) and modifiable CVD risk in women. This ancillary application to nuMoM2b HHS aims to test our hypotheses that sedentary behavior (SED) is a key, modifiable risk factor for CVD risk development in young women, including those with APO. SED is low-intensity behavior in a seated, reclining, or lying posture and has recently been identified as a CVD risk factor that is distinct from insufficient moderate-to-vigorous intensity activity (MVPA). Acute prolonged sitting results in marked, adverse responses such as increased blood pressure (BP), glucose, and lipids. Yet, major research gaps preclude the development and testing of specific SED-reduction interventions, especially for young women. Most studies measure SED poorly (e.g., by self-report) and do not statistically consider that SED is part of an all-day activity pattern (or composition). Further, mechanisms of how SED leads to CVD are unclear, further limiting intervention development. Last, almost no studies focus on young women. Our preliminary data suggest that SED is strongly associated with APOs and reduced cardiovascular health (e.g., BP) in young women post-pregnancy. Further, our laboratory has recently demonstrated novel associations between SED and mechanistic CVD measures, including greater arterial stiffness (higher pulse wave velocity [PWV]) and worse autonomic function (lower heart rate variability [HRV]). Collectively, SED is a novel, understudied risk factor for reduced cardiovascular health that our data suggest is highly relevant for young women. We have a unique, efficient, and time-sensitive opportunity to address these gaps by adding gold standard SED assessment via activPAL thigh-mounted accelerometer to the upcoming HHS2 exam. In this contemporary and diverse female cohort (n=4,050, age=36±6 years), we aim to quantify cross-sectional and longitudinal associations of SED with the clinical components of idea cardiovascular health (BP, BMI, total cholesterol, fasting glucose) by using state-of-the-art statistical methods that consider the compositional nature of SED and 24-hr activity and can correct existing, longitudinal self-reported SED via regression calibration. Also, we add HRV and PWV in Pittsburgh and Indiana (n=950) to efficiently study associations between SED and subclinical, mechanistic CVD outcomes in young women. Aim 3 will study interrelationships of SED, APO history, and ideal cardiovascular health to identify novel risk reductions strategies in this high-risk group with limited treatment options. This research will provide critical data to rigorously link SED, CVD risk, and contributing mechanisms and will inform age- and sex-specific SED interventions to test in young women, including those with APO.

抽象的与男性相比，年轻时女性患心血管疾病 (CVD) 的风险更快然而，很少有研究研究在这一关键时期可能减少 CVD 风险发展的因素。年轻女性的未产妊娠结局研究监测准妈妈的心脏健康状况。研究 (nuMoM2b HHS) 是一项独特的、多中心、纵向队列，起源于第一次怀孕期间，目前正在研究女性不良妊娠结局 (APO) 与可改变的 CVD 风险之间的关联。 nuMoM2b HHS 的这一辅助应用旨在测试我们的假设，即久坐行为 (SED) 是一个关键，年轻女性（包括患有 APO 的女性）发生 CVD 风险的可改变危险因素。 SED 是坐着、躺着或躺着的低强度行为，最近被确定为 CVD 不同于急性长时间久坐的危险因素。导致显着的不良反应，例如血压（BP）、血糖和血脂升高。研究差距阻碍了特定 SED 减少干预措施的开发和测试，特别是对于大多数研究对 SED 的测量效果不佳（例如通过自我报告），并且在统计上并未考虑到 SED 是全天活动模式（或组成）的一部分此外，SED 如何导致 CVD 的机制尚不清楚，最后，我们的初步数据几乎没有针对年轻女性的研究。表明 SED 与年轻女性的 APO 和心血管健康状况（例如血压）下降密切相关此外，我们的实验室最近证明了 SED 和怀孕后的新关联。机械性 CVD 措施，包括更大的动脉僵硬度（更高的脉搏波速度 [PWV]）和更糟糕的情况自主神经功能（较低的心率变异性 [HRV]）总体而言，SED 是一种新的、尚未得到充分研究的危险因素。我们的数据表明，心血管健康状况下降与年轻女性高度相关。我们有一个独特、高效且时间敏感的机会，可以通过添加黄金标准来解决这些差距在这个当代的 HHS2 考试中，通过安装在大腿上的 activPAL 加速度计进行 SED 评估。和多样化的女性队列（n=4,050，年龄=36±6岁），我们的目标是量化横截面和纵向 SED 与心血管健康临床要素（血压、体重指数、总胆固醇、禁食）的关联葡萄糖）通过使用最先进的统计方法，考虑 SED 和 24 小时的成分性质活动，并可以通过回归校准纠正现有的纵向自我报告 SED 此外，我们还添加了 HRV 和 HRV。匹兹堡和印第安纳州的 PWV (n=950) 有效研究 SED 与亚临床之间的关联，目标 3 将研究 SED、APO 病史和理想的相互关系。心血管健康，以确定治疗有限的高危人群的新风险降低策略这项研究将提供关键数据，将 SED、CVD 风险和影响机制严格联系起来。并将告知特定年龄和性别的 SED 干预措施，以对年轻女性（包括患有 APO 的女性）进行测试。