CORE B: METABOLIC AND MOLECULAR PHYSIOLOGY CORE

核心 B：代谢和分子生理学核心

基本信息

批准号：
9066636
负责人：
Andrea L Hevener
金额：
$ 32.66万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-05-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9066636
关键词：
Adipocytes Animals Area Arterial Fatty Streak Arts Biological Assay Biology Body Composition Cell Respiration Cells Collaborations Communities Complications of Diabetes Mellitus Conditioned Culture Media Consult Consultations Country Data Data Analyses Databases Diabetes Mellitus Diet Disease Dual-Energy X-Ray Absorptiometry Environment Epigenetic Process Evaluation Experimental Designs Faculty Feeding behaviors Fostering Gene Targeting Genetic Genetically Engineered Mouse Genomics Glucose Glycerol Glycerophospholipids Goals Hormones Human Human Genetics Indirect Calorimetry Inflammation Inflammatory Institutes Institution Insulin Intervention Knockout Mice Laboratories Leadership Liquid Chromatography Los Angeles Magnetic Resonance Imaging Mass Fragmentography Metabolic Metabolism Methodology Microscopy Mission Mitochondria Molecular Movement Mus Nuclear Receptors Obesity Outcome Oxygen Consumption Pathogenesis Patient Care Peptides Pharmacologic Substance Phenotype Physiological Physiology Plasma Preparation Procedures Process Productivity Protocols documentation Publications Quality Control Research Research Personnel Resources Rodent Sampling Scientific Advances and Accomplishments Series Services Signal Transduction Skeletal Muscle Sphingolipids Standardization Sterols Strategic Planning Techniques Technology Time Tissues Training Transgenic Mice Translational Research Translations Travel United States National Institutes of Health Work adipokines animal tissue assay development base bench to bedside chemokine cost cost effective cytokine data integration experience extracellular fatty acid metabolism flexibility functional genomics improved in vivo insight instrumentation insulin sensitivity insulin tolerance macrophage man metabolic abnormality assessment metabolic phenotype monocyte novel outreach prenol prevent therapeutic target

项目摘要

NIH-initiated efforts to centralize expertise, instrumentation, and facilities to promote comprehensive evaluation of genetically engineered mice, tissues and cells has improved our understanding of functional genomics and disease pathobiology. The Metabolic and Molecular Physiology Core (MMPC) provides investigators at UCLA, UCSD, Cedars-Sinai, and the Salk Institute with a series of state-of-the-art and cost-effective molecular and physiological assays not readily available from national phenotyping centers. The MMPC is divided into four sub-cores: A) Insulin sensitivity and metabolism, B) Oxidative metabolism and mitochondrial biology, C) LIPID MAPS-lipidomics, and D) Inflammatory siganling, and each sub-core offers extensive training and consultation on a variety of topics from experimental design to data interpretation and integration. Specifically, the MMPC provides services to assess: movement, feeding behavior, indirect calorimetry, body composition, glucose/insulin tolerance, insulin action, substrate metabolism and oxidative capacity, mitochondrial function, circulating and tissue lipids (lipidomics), circulating hormones / adipokines / cytokines, and diabetes complications. The MMPC maintains a tissue bio-bank as well as a comprehensive database of standard protocols for a vast number of phenotyping techniques, and phenotypic outcomes for a wide variety of genetically engineered mice. The MMPC leadership includes top investigators from the fields of nuclear receptor biology, lipid metabolism, inflammation, and adipocyte and skeletal muscle biology including: Peter Tontonoz, Andrea Hevener, Karen Reue, Rajendra Tangirala, Edward Dennis, Oswald Quehenberger. Strengths of the MMPC include the well-rounded and complementary expertise of its leadership and the exceptional track record of productivity and high impact scientific publications. The collaborative spirit ofthe MMPC team fosters a collegial environment and supports service well-coordinated with other DRC cores and institutional resources. The central goal ofthe MMPC is to advance the scientific capabilities ofthe DRC membership in leading-edge metabolic analysis to improve overall research quality with enhanced translation of research ideas from cell, tissue and mouse to man.

NIH引发的努力集中了专业知识，仪器和设施，以促进对基因工程小鼠，组织和细胞进行全面评估的全面评估，从而提高了我们对功能基因组学和疾病病理生物学的理解。代谢和分子生理学核心（MMPC）为UCLA，UCSD，Cedars-Sinai和Salk Institute提供了研究人员，并提供了一系列最先进的和具有成本效益的分子和生理测定法，而不容易从国家表型中心获得。 MMPC分为四个子核：a）胰岛素敏感性和代谢，b）氧化代谢和线粒体生物学，c）脂质图 - 脂肪组学，d）炎症性siganling以及每个子核提供了对实验性化诠释和集成的各种主题的广泛培训和咨询。 Specifically, the MMPC provides services to assess: movement, feeding behavior, indirect calorimetry, body composition, glucose/insulin tolerance, insulin action, substrate metabolism and oxidative capacity, mitochondrial function, circulating and tissue lipids (lipidomics), circulating hormones / adipokines / cytokines, and diabetes complications. MMPC维持组织生物银行以及针对多种表型技术的标准方案的全面数据库，以及各种基因工程小鼠的表型结果。 MMPC领导层包括来自核受体生物学领域，脂质代谢，炎症和脂肪细胞和骨骼肌生物学领域的顶级研究人员，包括：Peter Tontonoz，Andrea Hevener，Karen Reue，Rajendra Tangirala，Edward Dennis，Osward Dennis，Osward Queheld Quehenberger。 MMPC的优势包括其领导能力的全面和补充专业知识以及生产力和高影响力科学出版物的出色记录。 MMPC团队的协作精神促进了一个大学环境，并支持与其他刚果民主共和国核心和机构资源协调的服务。 MMPC的核心目的是提高DRC成员在领先的代谢分析中的科学能力，以增强从细胞，组织和小鼠到MAN的研究思想的翻译来提高整体研究质量。