Pathophysiology, site of disease onset and mechanisms of spread in amyotrophic lateral sclerosis

肌萎缩侧索硬化症的病理生理学、发病部位和传播机制

• 批准号: nhmrc : 1123026
• 负责人: Dr Parvathi Menon
• 金额: $ 48.15万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathophysiology-site-disease-lateral-sclerosis/947077
• 关键词: Pathophysiology; site; disease; onset; mechanisms

Amyotrophic lateral sclerosis (ALS) is a fatal disease of the human motor system resulting in progressive paralysis of voluntary muscles and death within 5 years of symptom onset. A key unresolved issue in the understanding of where ALS starts and what factors drive the disease. This project will utilise sophisticated techniques to determine the site of onset, factors controlling disease spread and ultimately identify treatment targets that could slow down or even stop disease progression.

肌萎缩性侧索硬化症（ALS）是人类运动系统的致命疾病，导致症状发作的5年内进行自愿性肌肉和死亡进行性瘫痪。在理解ALS从哪里开始以及哪些因素推动疾病的关键问题。该项目将利用复杂的技术来确定发病部位，控制疾病扩散的因素，并最终确定可能减慢甚至停止疾病进展的治疗靶标。