Tetrad: Genetics, Cell Biology, Biochemistry and Molecular Biology Training Grant

四分体：遗传学、细胞生物学、生物化学和分子生物学培训补助金

• 批准号: 10621187
• 负责人: Natalia Jura
• 金额: $ 109.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621187
• 关键词: Biochemistry; Cellular biology; Genetic; Grant; Molecular Biology; Training

Project Summary/Abstract The mission of the Tetrad program is to transform a group of bright, motivated, and diverse trainees into independent, innovative, and rigorous leaders in academic science, biotechnology, and affiliated disciplines. Our mission requires balancing disciplinary specialization, which is essential for depth and rigor, with the flexibility to think broadly across disciplines, which drives scientific breakthroughs. Towards this goal, the Tetrad program provides training in the fundamental principles of Genetics, Cell Biology, and Biochemistry and the use of these principles to practice the scientific method across disciplines and with rigor. The approaches and concepts in these areas are applicable to nearly every aspect of modern biology. Therefore, we believe that by building a solid foundation in these core areas, we can best equip our trainees for the fast pace of biomedical discovery and the expanding landscape of science related career options. Thus, our training does not get obsolete with new technological innovations or changing biological paradigms, but instead contributes to driving such breakthroughs by empowering students to engage in curiosity driven research. The emphasis on fundamental principles is complemented with exposure to cutting-edge biomedical findings and techniques to increase our students’ curiosity and foster their ability to tackle questions of broad significance. Our mission also requires training in essential professional skills, such as effective and accurate communication of science, an ability to work in diverse teams and an ability to identify a productive career path. Therefore, training activities such as proposal writing courses and career development workshops are woven throughout the program. Finally, our mission requires that efforts to diversify the biomedical workforce do not rely simply on increased recruitment of underrepresented students, but also depend on efforts to ensure their continued success. Therefore, activities such as training our program faculty to mentor across differences are essential program components. The broad range of scientific problems studied by the 79 training faculty and their strong commitment to graduate training has enabled Tetrad to provide an environment that nurtures the excitement and curiosity that lies at the heart of doing science and empowers all our trainees to be impactful members of the biomedical workforce. We plan on appointing 13 students for a duration of 2 years. Therefore, we request a total of 26 annual slots as we anticipate that each year, we will have 13 first year students and 13 second year students on this training grant. Trainees will be chosen from a highly qualified pool of students.

项目概要/摘要 Tetrad 计划的使命是将一群聪明、积极、多元化的学员转变为 学术科学、生物技术和附属学科的独立、创新和严谨的领导者。 使命需要平衡学科专业化，这对于深度和严谨性至关重要，同时具有灵活性 跨学科广泛思考，推动科学突破，为实现这一目标，Tetrad 计划。 提供遗传学、细胞生物学和生物化学基本原理及其使用的培训 跨学科和严格实践科学方法的原则。 这些领域几乎适用于现代生物学的各个方面。 在这些核心领域打下坚实的基础，我们可以为学员提供最好的装备，以适应快速的生物医学发现 以及科学相关职业选择的不断扩大，因此，我们的培训不会随着科学的发展而过时。 新的技术创新或改变生物范式，而是有助于推动这种 通过让学生参与好奇心驱动的研究来实现突破。 通过接触尖端生物医学发现和技术来补充原则，以提高我们的能力 我们的使命还需要培养学生的好奇心并培养他们解决具有广泛意义的问题的能力。 基本专业技能的培训，例如有效和准确的科学传播、 在不同的团队中工作，并有能力确定富有成效的职业道路，因此，开展诸如此类的培训活动。 提案写作课程和职业发展研讨会贯穿整个计划。 使命要求生物医学队伍多元化的努力不能仅仅依赖于增加招聘 代表性不足的学生，还要靠努力来确保他们的活动不断取得成功。 例如培训我们的项目教师以跨越差异进行指导是重要的项目组成部分。 79 名培训教师研究了广泛的科学问题以及他们对研究生的坚定承诺 培训使 Tetrad 能够提供一个培养兴奋和好奇心的环境 科学研究的核心，使我们所有的学员成为生物医学队伍中有影响力的成员。 计划任命 13 名学生，为期 2 年，因此，我们要求总共 26 个年度名额。 预计每年我们将有 13 名一年级学生和 13 名二年级学生获得此培训补助金。 学员将从高素质的学生库中选拔。

项目成果

The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice.

ÏPA3 噬菌体核被自组装的 2D 晶格包围。

• 发表时间: 2023-02-18
• 影响因子: 16.6
• 作者: Nieweglowska, Eliza S;Brilot, Axel F;Méndez;Kokontis, Claire;Baek, Minkyung;Li, Junrui;Cheng, Yifan;Baker, David;Bondy;Agard, David A
• 通讯作者: Agard, David A

Quasi-prime peptides: identification of the shortest peptide sequences unique to a species.

准引物肽：鉴定物种特有的最短肽序列。

• 发表时间: 2023-06
• 作者: Mouratidis, Ioannis;Chan, Candace S Y;Chantzi, Nikol;Tsiatsianis, Georgios Christos;Hemberg, Martin;Ahituv, Nadav;Georgakopoulos
• 通讯作者: Georgakopoulos

Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics.

用于功能基因组学的工程 CRISPR-Cas12a 的高阶组合染色质扰动。

• 发表时间: 2024-02-09
• 作者: Hsiung, C C;Wilson, C M;Sambold, N A;Dai, R;Chen, Q;Misiukiewicz, S;Arab, A;Teyssier, N;O'Loughlin, T;Cofsky, J C;Shi, J;Gilbert, L A
• 通讯作者: Gilbert, L A

A hexasome is the preferred substrate for the INO80 chromatin remodeling complex, allowing versatility of function.

六体是 INO80 染色质重塑复合物的首选底物，具有多功能性。

• 发表时间: 2022-06-02
• 影响因子: 16
• 作者: Hsieh, Laura J;Gourdet, Muryam A;Moore, Camille M;Muñoz, Elise N;Gamarra, Nathan;Ramani, Vijay;Narlikar, Geeta J
• 通讯作者: Narlikar, Geeta J

Transcription factor binding site orientation and order are major drivers of gene regulatory activity.

转录因子结合位点的方向和顺序是基因调控活动的主要驱动因素。

• 发表时间: 2023-04-22
• 影响因子: 16.6
• 作者: Georgakopoulos;Deng, Chengyu;Agarwal, Vikram;Chan, Candace S Y;Zhao, Jingjing;Inoue, Fumitaka;Ahituv, Nadav
• 通讯作者: Ahituv, Nadav