Administrative Core

行政核心

• 批准号: 10407936
• 负责人: Takahisa Kanekiyo
• 金额: $ 39.18万
• 依托单位: MAYO CLINIC JACKSONVILLE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10407936
• 关键词: Accountability; Address; Administrative Personnel; Advisory Committees; Aging; Alzheimer' s Disease; Apolipoprotein E; Biochemical; Bioinformatics; Biological Models; Biology; Biometry; Clinic; Collaborations; Communities; Complex; Data Analytics; Data Set; Department chair; Ensure; Event; Genotype; Goals; Impaired cognition; Individual; Information Resources; Institution; Interdisciplinary Study; Knowledge; Knowledge Portal; LDL-Receptor Related Protein 1; Lead; Leadership; Neurology; Neurosciences; Pathogenesis; Pathogenicity; Pathway interactions; Positioning Attribute; Progress Reports; Property; Protein Isoforms; Publications; Quality Control; Reagent; Recording of previous events; Reproducibility; Research; Research Personnel; Resource Sharing; Resources; Risk; Role; Site; Structure; System; Therapeutic; United States National Institutes of Health; Universities; Washington; analytical method; base; data access; data management; data sharing; design; experience; innovation; medical schools; meetings; nervous system disorder; novel; programs; protective effect; research in practice; responsible research conduct; sharing platform; symposium; synergism; web portal; web site

PROJECT SUMMARY (APOE U19 Core A: Administrative Core) The Administrative Core will lead this U19 project by providing administrative, fiscal, and scientific oversight and promoting synergy of all Cores and Projects to address the ApoE Cascade Hypothesis. Core A will serve several functions to facilitate the scientific objectives and rigor of this U19. It will also serve the broader scientific community by sharing knowledge, resources, and datasets through a web portal and by promoting collaboration through an annual ApoE Symposium. Core A will cooperate fully with NIA initiatives with a dedicated leadership team and administrative personnel with relevant experience. As the Co-PIs of this U19 project and Co-Leaders of Core A, Drs. Guojun Bu (Mayo Clinic Jacksonville) and David Holtzman (Washington University in St. Louis) are recognized leaders in the apoE field; each has more than 25 years of experience studying apoE and apoE receptors as they relate to the pathogenesis of AD and other aging- related conditions. Drs. Bu and Holtzman have a long history of collaboration and are well positioned to share leadership roles for this U19 program at the two coordinating institutions. They also have strong leadership experience each serving as a Department Chair and an Associate Director of Alzheimer’s Disease Research Center at their respective institution. Together with Dr. Alison Goate, who will serve as the Site-PI at Icahn School of Medicine at Mount Sinai, they will ensure integration and synergy across the U19 by pursuing the following aims: Aim 1: Provide administrative structure, fiscal oversight, and site coordination for the U19 program. Aim 2: Assume responsibility for the quality control of the U19 activities by ensuring responsible conduct of research, rigor, and reproducibility of research practices, and by ensuring compliance with all internal and external regulatory requirements. Promote and track open-access publications and facilitate submission of progress reports to NIH. Aim 3: Promote the scientific direction and integration of the U19 components by organizing meetings of the Internal Steering Committee and External Advisory Committee. Aim 4: Develop and maintain an apoE website what will serve as knowledge portal, and resource and data sharing platform. Aim 5: Organize Annual ApoE Symposium for U19 investigators as well as the broader scientific community to interact and share research findings. These innovative aims will ensure that the robust and rigorous efforts by the U19 team investigators will lead to new discoveries to inform therapeutic strategies.

项目摘要（APOE U19核心A：行政核心） 行政核心将通过提供行政，财政和科学监督来领导这项U19项目 并促进所有核心和项目的协同作用，以解决APOE级联假设。核心A将服务 多种功能促进了U19的科学目标和严格性。它也将为更广泛的服务 科学界通过网络门户共享知识，资源和数据集并促进 通过年度APOE研讨会合作。核心A将与NIA计划完全合作 具有相关经验的敬业领导团队和行政人员。作为此U19的共同案例 核心A的项目和共同领导者，Drs。 Gujun BU（Mayo Clinic Jacksonville）和David Holtzman （圣路易斯的华盛顿大学）是Apoe Field的公认领导人；每个人都有25年以上 研究APOE和APOE受体与AD和其他衰老的发病机理有关的经验 相关条件。博士。 BU和Holtzman的协作历史悠久，有能力分享 这两个协调机构的U19计划的领导角色。他们也有强大的领导 每人都担任部门主席和阿尔茨海默氏病研究副主任 中心在各自的机构中。与Alison Goate博士一起，他将在Icahn担任现场PI 西奈山医学院将通过追求U19的整合和协同作用 以下目的：目标1：为U19提供行政结构，财政监督和现场协调 程序。目标2：通过确保负责任的U19活动的质量控制负责 进行研究实践的研究，严格和可重复性，并确保遵守所有人 内部和外部监管要求。促进和跟踪开放式出版物并促进 提交进度报告给NIH。目标3：促进U19的科学方向和整合 组件通过组织内部指导委员会和外部咨询委员会的会议。目的 4：开发和维护一个APOE网站，将作为知识门户以及资源和数据共享 平台。 AIM 5：组织U19研究人员的年度APOE研讨会以及更广泛的科学 互动和分享研究结果的社区。这些创新的目标将确保强大和 U19团队调查人员的严格努力将导致新发现，以告知治疗策略。