Brain networks for specific motor control impairments following stroke

中风后特定运动控制障碍的大脑网络

• 批准号: 10620400
• 负责人: Na Jin Seo
• 金额: $ 6.1万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620400
• 关键词: Alaska Native; American Indians; Award; Base of the Brain; Biomechanics; Brain; Clinical; Communication; Data; Development; Doctor of Philosophy; Electroencephalography; Engineering; Feedback; Female; Fostering; Hand; Impairment; Individual; Knowledge; Motor; Motor Cortex; Phase; Process; Rehabilitation Outcome; Rehabilitation therapy; Reporting; Research; Research Personnel; Scientist; Sensory; Stroke; Training Activity; Underrepresented Minority; Upper Extremity; career; design; grasp; hand dysfunction; hand rehabilitation; improved; innovation; insight; male; motor control; motor impairment; neurological rehabilitation; neuromechanism; parent grant; personalized medicine; post stroke; programs; rehabilitation paradigm; rehabilitation research; relating to nervous system; skills; stroke survivor

PROJECT SUMMARY / ABSTRACT The objective of the parent grant (R01 HD094731) is to determine if combining TheraBracelet with hand task practice is superior to hand task practice alone for recovery of hand function post-stroke in an adequately powered study. The parent grant Aim 2 focuses on determining the effect of TheraBracelet on sensorimotor grip control and neural communication within the cortical sensorimotor network. This diversity supplement will provide a new insight into the neural mechanisms for different grip control impairments among individual stroke survivors. Specifically, the aim of this diversity supplement is to determine the brain network responsible for the feedforward and feedback motor control in stroke survivors. It is hypothesized that feedforward motor control will be associated with connectivity within the motor cortices during the motor planning phase, while feedback motor control will be associated with connectivity between the sensory and motor regions during the motor execution phase. This research is expected to unveil the specific brain network responsible for the feedforward and feedback motor control of the upper extremity. Innovation is in investigating brain networks and motor controls together. This new knowledge will be critical for the development of a personalized post-stroke rehabilitation paradigm: This paradigm may involve first assessing individual motor control processes to determine the specific motor control that is responsible for clinical motor impairment, followed by design of a personalized treatment to target the specific brain network responsible for the impaired motor control. Most importantly, this award will foster the underrepresented minority candidate (Mr. Adam Baker) as a career DPT/PhD researcher. The training activities will focus on developing new research skills for Mr. Baker to perform the supplement research and begin his research career. Specifically, Mr. Baker will (1) enhance the overall knowledge of the neurorehabilitation research field, (2) acquire proficiency in quantifying, analyzing, and interpreting feedforward and feedback motor control biomechanics data and EEG-based brain network data, and (3) develop a successful application for a DPT/PhD program. Therefore, this supplement award will contribute to enhancing diversity in the biomedical workforce, as only 2,000 females are American Indian or Alaskan Native out of 1.76 million employed scientists and engineers holding doctorates according to NSF report (data suppressed for males due to reliability).

项目概要/摘要 家长资助 (R01 HD094731) 的目标是确定是否将 TheraBracelet 与手动任务结合起来 对于中风后手部功能的充分恢复而言，练习优于单独的手部任务练习 动力研究。家长资助目标 2 重点确定 TheraBracelet 对感觉运动握力的影响 皮质感觉运动网络内的控制和神经通讯。这种多样性补充将提供 对中风幸存者中不同握力控制障碍的神经机制的新见解。 具体来说，这种多样性补充的目的是确定负责前馈的大脑网络 和中风幸存者的反馈运动控制。假设前馈电机控制将是 与运动规划阶段运动皮质内的连接相关，而反馈运动 控制将与运动执行期间感觉区域和运动区域之间的连接相关联 阶段。这项研究预计将揭示负责前馈和 上肢的反馈运动控制。创新在于研究大脑网络和运动控制 一起。这些新知识对于个性化中风后康复的发展至关重要 范式：该范式可能涉及首先评估各个运动控制过程以确定具体的 负责临床运动障碍的运动控制，然后设计个性化治疗 针对导致运动控制受损的特定大脑网络。最重要的是，这个奖项将 培养代表性不足的少数族裔候选人（亚当·贝克先生）作为职业 DPT/博士研究员。培训内容 活动的重点是为贝克先生发展新的研究技能，以进行补充研究和 开始他的研究生涯。具体来说，贝克先生将 (1) 增强以下方面的整体知识： 神经康复研究领域，(2) 熟练掌握量化、分析和解释前馈 并反馈运动控制生物力学数据和基于脑电图的脑网络数据，以及（3）开发成功 申请 DPT/PhD 课程。因此，该补充奖将有助于增强多样性 生物医学劳动力，因为在 176 万人口中，只有 2,000 名女性是美洲印第安人或阿拉斯加原住民 根据 NSF 报告，雇用了拥有博士学位的科学家和工程师（由于男性的数据被抑制） 到可靠性）。