Deorphanization of Schistosome Cytochrome P450

血吸虫细胞色素 P450 的脱孤儿化

基本信息

批准号：
9035124
负责人：
DAVID LEE WILLIAMS
金额：
$ 23.25万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-15 至 2018-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9035124
关键词：
Accounting Adult Animals Antifungal Agents Arachidonic Acids Azoles Catabolism Cell membrane Cells Cessation of life Cholesterol Chronic Disease Clinical Communication Critiques Cytochrome P450 Data Detoxification Process Development Disease Drug Metabolic Detoxication Drug Targeting Drug resistance Ecdysteroids Eicosanoids Enzymes Ergosterol Escherichia coli Family Foundations Fungal Components Genes Genome Goals Hormones Human Imidazole Infection Insecta Investigation Label Lead Link Lipids Messenger RNA Metabolic Pathway Miconazole Molecular Target Orphan Parasites Pharmaceutical Preparations Pharmacology Pharmacotherapy Poison Polyunsaturated Fatty Acids Praziquantel Praziquantel resistance Production Proteins RNA Interference Recombinant Proteins Recombinants Reproduction Research Proposals Retinoids Schistosoma Schistosoma mansoni Schistosomiasis Secosteroids Signal Pathway Signaling Molecule Staging Structure-Activity Relationship Testing Vitamin A Vitamin D Xenobiotics Yeasts analog chemotherapy design disability drug development enzyme pathway evidence base improved inhibitor/antagonist metabolomics neglect novel therapeutics protein function public health relevance scaffold screening steroid hormone

项目摘要

DESCRIPTION (provided by applicant): The goal of this R21 Exploratory/Developmental Research proposal is to identify the function of the only cytochrome P450 protein present in Schistosoma mansoni, a causative agent of schistosomiasis. We hypothesize that the unique schistosome cytochrome P450 is essential for worm communication, survival, reproduction, and development and that its function can be identified by linking it to specific metabolic pathways. We believe that understanding the function of this protein will identify critical signaling pathway and will be useful in the discovery of new drugs for schistosomiasis, an important, neglected disease with more than 200 million people infected resulting in 200,000 deaths annually and untold chronic illness and disability. Only one drug is available for schistosomiasis treatment and there are concerns that drug resistance is evolving.

描述（由应用程序提供）：该R21探索性/发育研究建议的目标是确定Schistosoma Mansoni中存在的唯一细胞色素P450蛋白，这是血吸虫病的关键药物。我们假设独特的螺旋体细胞色素P450对于蠕虫的交流，生存，繁殖和发育至关重要，并且可以通过将其链接到特定的代谢途径来识别其功能。我们认为，了解该蛋白质的功能将识别关键的信号通路，并将在发现新药的血吸虫病新药中有用，这是一种重要的，被忽视的疾病，被感染超过2亿人，导致每年200,000人死亡，慢性病和残疾无数。只有一种药物可用于血吸虫病治疗，并且担心耐药性正在发展。