Center on Intersystem Regulation by Drugs of Abuse

滥用药物系统间监管中心

基本信息

批准号：
10611901
负责人：
ELLEN M UNTERWALD
金额：
$ 149.26万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-30 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10611901
关键词：
Absence of pain sensation Acceleration Address Alcohols Animals Behavior Biochemical Pharmacology Caliber Cannabinoids Cells Collaborations Core Facility Discipline Disease Drug Regulations Education Faculty Flow Cytometry Fostering Funding Future Generations G-Protein-Coupled Receptors Gene Expression Goals Grant HIV HIV Infections HIV-1 Health Care Costs Human Resources Immunology Individual Infection Inflammation Interdisciplinary Study Investigation Knowledge Measures Mentors Methods Mission Molecular Biology National Institute of Drug Abuse Neuroimmune Neurons Neurotransmitters Nicotine Opioid Pain Pain management Peer Review Pharmaceutical Preparations Physiological Pilot Projects Population Postdoctoral Fellow Prevention strategy Productivity Public Health Publications Research Research Personnel Research Project Grants Research Support Research Training Resources Scientist Self Administration Services Societies Students Substance Addiction Substance abuse problem System Techniques Technology Therapeutic Training United States National Institutes of Health Universities addiction behavioral economics career catalyst chemokine cytokine drug of abuse fluorescence microscope humanized mouse in vivo calcium imaging innovation medical schools miniaturize mouse model new technology next generation novel novel strategies opioid sparing programs psychostimulant synergism treatment strategy

项目摘要

The NIDA P30 Core Center, entitled “Center on Intersystem Regulation by Drugs of Abuse”, provides outstanding scientific expertise and resources to NIH investigators in order to advance research productivity and innovations in addiction research. The Center has proven to be a catalyst for interdisciplinary studies and has created synergy between investigators from diverse disciplines. The major themes of the Center that will be pursued in this 5 year renewal include: 1) mechanisms of addiction and identification of novel targets with therapeutic potential; 2) effects of drugs of abuse on HIV infection; 3) neuroimmune interactions, including cross-talk between classical neurotransmitter systems and chemokines/cytokines as related to addiction, pain, inflammation and HIV; 4) pain and analgesia with the goal of identifying opioid-sparing treatments for pain. Research is carried out on a broad spectrum of substances including opioids, cannabinoids, psychostimulants, nicotine and alcohol. The Center consists of five Research Support Cores: The Animal Core for Addiction Related Behaviors, Biochemical Pharmacology Core, Cell and Immunology Core, Integrated Physiological Systems and Pain Core, and the Molecular Biology Core, in addition to the Administrative and Pilot Project Cores. The Core personnel bring to the Center a broad array of expertise to address scientific questions related to drugs of abuse, addiction, pain and HIV from multiple approaches leading to research synergy. This unique aspect of the P30 Center at Temple encourages collaborations that extend beyond a single discipline to address novel hypotheses and significantly accelerate the progress of individual research programs. Implementation of several new state-of-the-art approaches are proposed in this renewal application that will add major strengths to the Center. The NIDA P30 Core Center will provide cutting-edge technologies to expand the impact of NIH-funded research projects related to NIDA's mission through collaborations nation-wide. In addition, research training and mentoring of early career scientists will continue to be an important function. The Center will serve as a national resource to stimulate innovative scientific discoveries that will result in new knowledge to bear on substance abuse.

NIDA P30 核心中心，题为“滥用药物系统间监管中心”，提供为 NIH 研究人员提供出色的科学专业知识和资源，以推进研究事实证明，该中心是成瘾研究的催化剂。跨学科研究，并在不同学科的研究人员之间建立了协同作用。该中心在这五年更新中将追求的主要主题包括：1）成瘾和具有治疗潜力的新靶点的识别；2) 滥用药物对人的影响； HIV感染；3）神经免疫相互作用，包括经典神经递质之间的串扰与成瘾、疼痛、炎症和 HIV 相关的系统和趋化因子/细胞因子 4) 疼痛和镇痛研究的目的是确定节省阿片类药物的疼痛治疗方法。广泛的物质，包括阿片类药物、大麻素、精神兴奋剂、尼古丁和酒精。五个研究支持核心中心：成瘾相关行为的动物核心，生化药理学核心、细胞和免疫学核心、综合生理系统和除了行政和试点项目核心之外，还包括疼痛核心和分子生物学核心。核心人员为中心带来广泛的专业知识来解决科学问题通过多种研究方法与滥用药物、成瘾、疼痛和艾滋病毒相关 Temple P30 中心的这一独特之处鼓励扩大合作。超越单一学科来解决新的假设并显着加速进展提出了几种新的最先进方法的实施。在此更新申请中，NIDA P30 核心中心将增添主要优势。提供尖端技术来扩大 NIH 资助的相关研究项目的影响 NIDA 的使命是通过全国范围内的合作开展研究培训和早期指导。职业科学家将继续发挥重要作用，成为国家资源。激发创新的科学发现，从而产生对实质内容有影响的新知识虐待。

项目成果

期刊论文数量（312）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Peptide Receptor Fpr1 Ccr2, following Activation of the Formyl Cross-desensitization of Ccr1, but Not

肽受体 Fpr1 Ccr2，在 Ccr1 甲酰交叉脱敏激活后，但不是

DOI：
发表时间：
1970-01-01
期刊：
影响因子：
0
作者：
Thomas J Rogers;Filip Bednar;Changcheng Song;Giuseppe Bardi;William
通讯作者：
William

Assessment of Blood-Brain Barrier Permeability Using Miniaturized Fluorescence Microscopy in Freely Moving Rats.

使用小型荧光显微镜评估自由活动大鼠的血脑屏障渗透性。

DOI：
10.1007/7651_2020_315
发表时间：
2021-03-11
期刊：
Methods in molecular biology
影响因子：
0
作者：
J. Barr;G. Brailoiu;E. Unterwald;E. Brǎiloiu
通讯作者：
E. Brǎiloiu

The role of DJ-1 in human primary alveolar type II cell injury induced by e-cigarette aerosol.

DJ-1 在电子烟气溶胶诱导的人原发性肺泡 II 型细胞损伤中的作用。

DOI：
10.1152/ajplung.00567.2018
发表时间：
2019-10-01
期刊：
American journal of physiology. Lung cellular and molecular physiology
影响因子：
0
作者：
K. Bahmed;Chih;H. Simborio;Loukmane Karim;M. Aksoy;S. Kelsen;D. Tomar;Madesh Muniswamy;J. Elrod;Elise M. Messier;R. Mason;E. Unterwald;T. Eisenstein;G. Criner;B. Kosmider
通讯作者：
B. Kosmider

Abrupt or precipitated withdrawal from morphine induces immunosuppression.

突然或突然戒断吗啡会引起免疫抑制。

DOI：
发表时间：
2002-06
期刊：
影响因子：
3.3
作者：
Rahim, Rahil T;Adler, Martin W;Meissler Jr, Joseph J;Cowan, Alan;Rogers, Thomas J;Geller, Ellen B;Eisenstein, Toby K
通讯作者：
Eisenstein, Toby K

Differential effects of agonists on adenylyl cyclase superactivation mediated by the kappa opioid receptors: adenylyl cyclase superactivation is independent of agonist-induced phosphorylation, desensitization, internalization, and down-regulation.

激动剂对 kappa 阿片受体介导的腺苷酸环化酶超活化的不同作用：腺苷酸环化酶超活化与激动剂诱导的磷酸化、脱敏、内化和下调无关。