Eye Movement Rehabilitation in Low Vision Patients

低视力患者的眼动康复

基本信息

批准号：
10612338
负责人：
Peter John Bex
金额：
$ 36.97万
依托单位：
NORTHEASTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10612338
关键词：
Activities of Daily Living Affect Age American Awareness Basic Science Behavior Blindness Clinical Computers Contrast Sensitivity Control Locus Coupling Cues Development Disease Disease Progression Economics Eye Eye Movements Eye diseases Feedback Goals Hand Health Impairment Lead Learning Location Low Prevalence Maps Mental Depression Methods Motor Movement New England Optometry Pathologic Patients Pattern Performance Persons Psychophysics Public Health Quality of life Questionnaires Reading Rehabilitation therapy Research Residual state Resolution Retina Retinal blind spot Saccades Scientist Scotoma Sensory Series Services Smooth Pursuit Standardization System Television Time Training Translating Universities Vision Visual Visual Acuity Visual System Visual impairment clinical application college evidence base experience eye hand coordination fovea centralis functional improvement gaze improved interest macula mortality oculomotor rehabilitation strategy sample fixation social visual feedback visual tracking

项目摘要

Project Summary/ Abstract Approximately 217 million people worldwide currently suffer from low vision, which impact a broad range of activities of daily living and is associated with depression and increased mortality. Over half of the patients presenting for low vision services have eye disease that affects the fovea and surrounding macula and leads to central vision loss (CVL). People with CVL are forced to use eccentric vision as a substitute for their impaired fovea, however eye movement control and visual function is impaired with eccentric vision. This proposal brings together basic and clinical vision scientists at Northeastern University, the Lighthouse Guild and New England College of Optometry in order to help people with CVL to learn to use their remaining vision more effectively. Recent evidence shows that rehabilitation methods can help improve oculomotor control and this can lead to improved functional outcomes. We have developed new feedback-based methods that aim to improve eccentric vision training in patients with CVL. In a series of studies we examine rehabilitation of fixation control, smooth pursuit eye movements that track moving objects and saccadic eye movements that abruptly change the point of regard. We examine how visual feedback, scotoma awareness methods and hand-eye coordination can improve eccentric vision usage. Improvements in oculomotor control are quantified with eye tracking methods and associated changes in visual function are quantified with acuity, contrast sensitivity and reading performance. The proposed research therefore develops and translates state-of-the-art methods in basic science to clinical applications. Accomplishing the proposed aims will provide new and improved methods for rehabilitation strategies for visual impairment. The ultimate goal of this proposal is to maximize the residual visual function of people with low vision and to help them to live independently, thereby improving quality of life and minimizing the economic and social burden of visual impairment.

项目概要/摘要目前全球约有 2.17 亿人患有低视力，这影响了广泛的日常生活活动与抑郁症和死亡率增加有关。超过一半的患者接受低视力服务的人患有影响中央凹和周围黄斑并导致中央视力丧失（CVL）。患有 CVL 的人被迫使用偏心视力来替代他们受损的视力然而，偏心视力会损害眼球运动控制和视觉功能。这个提议汇集了东北大学、灯塔协会和纽约大学的基础和临床视觉科学家英格兰视光学院旨在帮助CVL患者学会更多地利用他们的剩余视力有效地。最近的证据表明，康复方法可以帮助改善动眼神经控制，这可能会导致改善功能结果。我们开发了新的基于反馈的方法，旨在改进 CVL 患者的偏心视力训练。在一系列研究中，我们检查了固定的康复控制、平滑追踪移动物体的眼球运动和扫视眼球运动突然改变关注点。我们研究视觉反馈、暗点意识方法和手眼协调可以改善偏心视觉的使用。动眼神经控制的改善是通过眼动追踪方法进行量化，并通过敏锐度对视觉功能的相关变化进行量化，对比敏感度和阅读性能。因此，拟议的研究开发了基础科学的最先进方法并将其转化为临床应用程序。实现拟议目标将为康复提供新的和改进的方法视力障碍的策略。该提案的最终目标是最大化剩余视觉功能帮助视力低下的人独立生活，从而提高生活质量并最大限度地减少视力障碍视力障碍的经济和社会负担。