Northwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS Research

西北核心临床研究站点：艾滋病毒/艾滋病研究的跨组学

• 批准号: 10612741
• 负责人: Frank J Palella
• 金额: $ 401.48万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-10 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612741
• 关键词: Acceleration; Active Sites; Address; Advocacy; Aging; Agreement; Basic Science; Behavior; Big Data; Biological Assay; Biological Factors; Biological Markers; Biological Process; Biology; Blood; Blood specimen; Catalogs; Cells; Chronic; Clinical; Clinical Research; Cohort Studies; Collaborations; Collection; Communities; Complement; Complex; County; Data; Data Analyses; Data Collection; Data Set; Development; Diagnosis; Disease; Disease Outcome; Disease model; Enrollment; Ensure; Epidemic; Event; Funding; Gene Expression; Gene Expression Profile; Genes; Genetic; Genetic Determinism; Genetic Risk; Genome; Genotype; Goals; HIV; HIV Infections; HIV/AIDS; Health; Health Insurance Portability and Accountability Act; Health Policy; Healthcare; Heritability; Hospitals; Human; Image; Immune System Diseases; Immune response; Infection; Inflammation; Inflammation Mediators; Inflammatory; Information Technology; Informed Consent; Infrastructure; Interdisciplinary Study; Knowledge; Laboratories; Leadership; Link; Maintenance; Measures; Medical Records; Modeling; Modeling of Functional Interactions; Molecular Profiling; Office of Administrative Management; Outcome; Participant; Pathogenicity; Pathway interactions; Pattern; Persons; Pharmaceutical Preparations; Phenotype; Policies; Policy Developments; Populations at Risk; Practice Guidelines; Precision Medicine Initiative; Predisposition; Procedures; Production; Productivity; Property; Prospective Studies; Protocols documentation; Psychosocial Factor; Public Health; Quality Control; Recording of previous events; Reporting; Reproducibility; Research; Research Priority; Research Project Grants; Resources; Risk; Running; Science; Scientific Advances and Accomplishments; Scientist; Severity of illness; Shapes; Signal Pathway; Signaling Protein; System; Testing; Tissues; Training; United States National Institutes of Health; Universities; Variant; Virus; Virus Replication; Work; adjudication; clinical care; clinical research site; co-infection; cohort; comorbidity; cooking; data integration; epidemiology study; flexibility; follow-up; functional genomics; genetic variant; good laboratory practice; immune activation; improved; inclusion criteria; innovation; insight; microbiome; multidisciplinary; new therapeutic target; next generation; novel; participant enrollment; participant retention; patient engagement; predictive modeling; programs; protein expression; protein protein interaction; quality assurance; repository; resilience; response; risk variant; sample collection; social science research; vaccine development; virus host interaction

The Northwestern University and the Ruth M. Rothstein CORE Center of the Cook County Health & Hospitals System Clinical Research Site (NC CRS) addresses the highest research priorities in HIV/AIDS research through retention and maintenance of the cohort, collection and repository storage of blood samples, and development and implementation of the unified science agenda. Through the leadership we provide and the data and blood samples we collect, the NC CRS actively contributes to core protocols and thematic sub- studies to characterize the long-term, natural and treated history of HIV infection in a representative cohort of people at substantial risk of becoming infected with the virus. We strictly adhere to good practice guidelines, established policies and procedures, and robust quality assurance and quality control measures to ensure the accuracy, reproducibility, and integrity of the clinical and laboratory data and blood samples. Scientific and administrative management provides both the flexibility and means to conduct multidisciplinary research projects as well as the resources to respond rapidly to recent scientific progress. For the past 35 years, we have maintained a comprehensive portfolio of biomedical and social science research on HIV and its related coinfections, comorbidities, and other complications. The diversity of the work makes possible a broad and multidisciplinary view of these high priority topics for understanding the basic biology of HIV, immune dysfunction and chronic inflammation, and genetic determinants. Scientific questions take full advantage of the strengths of the cohort, namely, its duration and the continuity of data and blood samples that timespan provides. Data and blood samples are available from people before and after infection, before and after beginning medications, or before and after the development of comorbidities or their complications. Productive relationships across the combined cohort, as well as other consortia and organizations, have coalesced around specific issues to advance scientific knowledge, the health of people, and policy development. By capitalizing on the expertise and unique resources of a multidisciplinary team of experts, we will build on our studies of genome sequence, patterns of gene and protein expression, and metabolite concentrations and changes (trans-omics dataset), along with information from people's medical records, to identify genes and pathways that play a role in disease and determine how they interact with HIV. Hierarchal models that predict the network behavior that gives rise to a phenotype will unravel the complexity of disease to provide novel and important insights into biological processes for testing or generating a set of hypotheses about disease mechanisms. During the next 7-year funding cycle, the NC CRS will continue support for the cohort and trans- omics for HIV/AIDS research that complements and extends the NIH Precision Medicine Initiative that connects genotype and phenotype and aligns with the NIH Big Data Initiative that supports innovative and transformative approaches to advance understanding of human health and disease.

西北大学和库克县健康与医院 Ruth M. Rothstein CORE 中心 系统临床研究中心 (NC CRS) 致力于艾滋病毒/艾滋病研究的最高研究优先事项 通过保留和维护队列、收集和储存血液样本，以及 制定和实施统一的科学议程。通过我们提供的领导力和 我们收集的数据和血液样本，NC CRS 积极致力于核心协议和主题子项目 研究旨在描述代表性队列中艾滋病毒感染的长期、自然和治疗史 有感染该病毒的巨大风险的人。我们严格遵守良好实践准则， 既定的政策和程序，以及健全的质量保证和质量控制措施，以确保 临床和实验室数据以及血液样本的准确性、再现性和完整性。科学与 行政管理提供了进行多学科研究的灵活性和手段 快速响应最新科学进展的项目和资源。在过去的35年里，我们 保持着关于艾滋病毒及其相关疾病的全面的生物医学和社会科学研究组合 合并感染、合并症和其他并发症。工作的多样性使得广泛和 这些高度优先主题的多学科观点，以了解艾滋病毒的基本生物学、免疫 功能障碍和慢性炎症以及遗传决定因素。科学问题充分利用 该队列的优势，即其持续时间以及该时间跨度的数据和血液样本的连续性 提供。数据和血液样本可从感染前和感染后、感染前和感染后的人们获得 开始药物治疗，或出现合并症或其并发症之前和之后。富有成效 合并后的群体以及其他联盟和组织之间的关系已经围绕 促进科学知识、人民健康和政策制定的具体问题。通过大写 凭借多学科专家团队的专业知识和独特资源，我们将在我们的研究基础上 基因组序列、基因和蛋白质表达模式以及代谢物浓度和变化 （跨组学数据集）以及人们医疗记录中的信息，以识别基因和通路 它们在疾病中发挥作用并决定它们如何与艾滋病毒相互作用。预测的分层模型 产生表型的网络行为将揭示疾病的复杂性，从而提供新的和 对测试或生成一组有关疾病的假设的生物过程的重要见解 机制。在下一个 7 年资助周期内，NC CRS 将继续支持队列和跨 HIV/艾滋病研究组学补充和扩展了 NIH 精准医学计划 连接基因型和表型，并与支持创新和研究的 NIH 大数据计划保持一致 促进对人类健康和疾病的了解的变革性方法。

项目成果

A web-based positive-affect intervention to reduce stress and improve well-being in women living with HIV - feasibility and acceptability of a single-arm, pilot study.

基于网络的积极影响干预措施，旨在减轻艾滋病毒感染妇女的压力并改善其福祉——单臂试点研究的可行性和可接受性。

• 发表时间: 2024-01
• 影响因子: 1.7
• 作者: Freedman, Melanie E;Weber, Kathleen M;Yohannes, Tsion;Cohen, Mardge H;Moskowitz, Judith T
• 通讯作者: Moskowitz, Judith T

Cumulative Human Immunodeficiency Virus (HIV)-1 Viremia Is Associated With Increased Risk of Multimorbidity Among US Women With HIV, 1997-2019.

1997 年至 2019 年，累积人类免疫缺陷病毒 (HIV)-1 病毒血症与美国 HIV 感染女性多重发病风险增加相关。

• 发表时间: 2023-02
• 影响因子: 4.2
• 作者: Morton, Zoey P;Christina Mehta, C;Wang, Tingyu;Palella, Frank J;Naggie, Susanna;Golub, Elizabeth T;Anastos, Kathryn;French, Audrey L;Kassaye, Seble;Taylor, Tonya N;Fischl, Margaret A;Adimora, Adaora A;Kempf, Mirjam;Tien, Phyllis C;Of
• 通讯作者: Of