Free-living and in-lab effects of sedentary time on cardiac autonomic nervous system function in youth with overweight/obesity

久坐时间对超重/肥胖青少年心脏自主神经系统功能的自由生活和实验室影响

• 批准号: 10598404
• 负责人: Kelsey Lynn McAlister
• 金额: $ 4.66万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598404
• 关键词: Acute; Affect; Age; Automobile Driving; Autonomic nervous system; Behavior Therapy; Behavioral; Cardiac; Cardiovascular Diseases; Childhood; Cognition; Data Collection; Development; Devices; Disease Outcome; Disease Progression; Electrocardiogram; Equilibrium; Exercise; Frequencies; Funding; Health; Heart; Heart Rate; Hour; Individual; Interruption; Intervention; Knowledge; Link; Measures; Mediating; Methodology; Nervous System Physiology; Obesity; Outcome; Overweight; Pathway interactions; Persons; Phase; Physical activity; Physiological; Physiological Processes; Population; Prevention; Public Health; Randomized, Controlled Trials; Research Design; Research Personnel; Rest; System; Testing; Time; United States National Institutes of Health; Walking; Work; Youth; cardiovascular disorder risk; fighting; fitness; glucose metabolism; heart rate variability; high risk; improved; indexing; innovation; insight; mortality; response; sedentary

PROJECT ABSTRACT Cardiovascular disease (CVD) is a significant public health burden and remains the leading cause of mortality among the U.S population. CVD progression can originate during childhood, and youth with overweight and obesity (OW/OB) have an increased risk for CVD development. One mechanism that contributes to the development of CVD is imbalanced cardiac autonomic nervous system (ANS) function. The cardiac ANS governs the heart’s response to everyday conditions via sympathetic and parasympathetic modulation, in which balance of the sympathetic and parasympathetic systems indicates healthy cardiac ANS function. However, youth with OW/OB present overactivation of the sympathetic modulation of the heart, which is strongly associated with several adverse health outcomes. Studies in youth demonstrated that increased sedentary time (ST) is related to higher CVD risk. However, it is unknown whether the associations between ST and CVD are due to time displaced from physical activity to ST or due to underlying physiological processes stimulated by ST. Reduced cardiac ANS balance may be mediating the ST and CVD risk association, but few researchers have examined the associations between ST and cardiac ANS function, and none have examined associations within a day or within a person, and have not experimentally manipulated prolonged ST. Understanding the relationship of ST to cardiac ANS function may provide insight toward methodologies to alleviate CVD development, especially in youth with OW/OB who are at significantly higher risk for CVD. This project aims to leverage data collection opportunities from the NIH-funded Sedentary Breaks Study 3 (P.I. Dr. Britni Belcher; R01DK12333) to elucidate observational and experimental relationships between ST and cardiac ANS function via measures of heart rate variability in youth with OW/OB. The first phase of this project will investigate daily associations between objectively-measured ST and cardiac ANS function under habitual conditions. In the second phase, this project will have an innovative experimental component to determine the acute effects of interrupting ST on cardiac ANS function in-lab over seven consecutive days among three conditions: 1) continuous sitting (SIT), 2) sitting interrupted by 3-minute bouts of moderate-intensity walking every 30 minutes (SIT+WALK), and 3) sitting interrupted by a single 18-minute bout of moderate-intensity walking (EX).

项目摘要 心血管疾病（CVD）是一个重大的公共卫生负担，并且仍然是导致死亡的主要原因 在美国人群中，CVD 的进展可能起源于儿童期以及超重和青少年时期。 肥胖 (OW/OB) 会增加发生 CVD 的风险。 CVD 的发展是心脏自主神经系统 (ANS) 功能失衡所致。 心脏通过交感神经和副交感神经的调节对日常状况的反应，其中平衡 交感神经和副交感神经系统的异常表明心脏 ANS 功能健康。 OW/OB 表现出心脏交感神经调节的过度激活，这与以下因素密切相关： 一些不良的健康后果。 对青少年的研究表明，久坐时间 (ST) 增加与 CVD 风险增加有关，但事实并非如此。 未知 ST 和 CVD 之间的关联是否是由于从体力活动转移到 ST 的时间造成的 或由于 ST 刺激的潜在生理过程导致心脏 ANS 平衡降低。 ST 与 CVD 风险之间的关联，但很少有研究人员研究过 ST 与心脏病之间的关联 ANS 功能，没有人检查过一天内或人体内的关联，也没有进行过实验 了解 ST 与心脏 ANS 功能的关系可能会提供见解。 寻找缓解 CVD 发展的方法，尤其是患有 OW/OB 的青少年，他们的病情显着 CVD 风险较高。 该项目旨在利用 NIH 资助的久坐休息研究 3（P.I. Britni Belcher 博士；R01DK12333）阐明 ST 和 通过测量 OW/OB 青少年的心率变异性来测量心脏 ANS 功能 该项目的第一阶段。 将调查习惯性情况下客观测量的 ST 与心脏 ANS 功能之间的日常关联 在第二阶段，该项目将有一个创新的实验部分来确定。 实验室连续 7 天中断 ST 对三名患者中心脏 ANS 功能的急性影响 条件：1) 连续静坐 (SIT)，2) 每隔一段时间坐着进行 3 分钟的中等强度步行 30 分钟（坐+步行），以及 3）坐着，中间进行一次 18 分钟的中等强度步行（EX）。