SMART POR: Supporting and Mentoring Across Respiratory Topics in Patient Oriented Research

SMART POR：支持和指导以患者为导向的研究中的呼吸主题

• 批准号: 10591121
• 负责人: Valerie G Press
• 金额: $ 12.12万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591121
• 关键词: Accident and Emergency department; Address; Adult; Affect; Asthma; Caring; Chimera organism; Chronic Disease; Chronic Obstructive Pulmonary Disease; Cluster randomized trial; Collaborations; Consolidated Framework for Implementation Research; Data; Data Collection; Data Reporting; Development; Education; Effectiveness; Evaluation; Failure; Foundations; Hospital Societies; Hospitalization; Hospitals; Hybrids; Infrastructure; Intervention; Lead; Literature; Logic; Medicine; Mentors; Methodology; Methods; Midcareer Investigator Award in Patient-Oriented Research; Modeling; Names; National Heart, Lung, and Blood Institute; Outcome; Patient-Focused Outcomes; Patients; Peer Review; Persons; Pharmaceutical Preparations; Process; Program Evaluation; Program Sustainability; Publications; Qualitative Methods; Reporting; Research; Research Personnel; Research Project Grants; Review Literature; Site; Standardization; Testing; Time; Training; Visit; Walking; Work; acute care; care delivery; care outcomes; career; comparative; concept mapping; data acquisition; data harmonization; data standards; design; dissemination strategy; evidence base; experience; health care delivery; human centered design; implementation context; implementation framework; implementation intervention; implementation science; improved; improved outcome; innovation; mortality; novel; patient oriented research; post implementation; programs; prospective; pulmonary function decline; respiratory; therapy design; tool; trial comparing; virtual

PROJECT ABSTRACT Chronic Obstructive Pulmonary Disease (COPD) affects more than 16 million US adults, many of whom experience high rates of acute care revisits (emergency department and hospital) after initial COPD hospitalization. These frequent exacerbations, often due to transition of care (TOC) failures, lead to lung function decline and earlier mortality. Large multi-site studies are needed to address ongoing gaps in fundamental effectiveness and implementation data, before widescale implementation of effective COPD TOC programs and successful reduction of revisits. My current NHLBI R01 aims to address these gaps in effectiveness and implementation by testing COPD TOC programs across 20 diverse US hospitals to improve health care delivery and outcomes for patients with COPD. My R01 simultaneously uses implementation science (IS) and human-centered design (HCD) methods. While these methods are rigorous and complimentary, integrating these qualitative approaches in a prospective manner could optimize their potential to impact the design and implementation of interventions in order to obtain data and ultimately inform care transformation. Further, standardizing metrics for evaluating and reporting COPD TOC program and revisit data could significantly improve outcome comparisons between COPD TOC programs and studies. The K24 will allow me to address these methodology gaps by building upon my R01 research, mentoring program, and infrastructure to develop, test, and disseminate integrated IS and HCD qualitative and quantitative methods for use in Patient Oriented Research. I will collaborate with my mentees and R01 research team experts in IS and HCD methods to develop an integrated approach named "CHIMERA"; additionally, I will collaboratively develop harmonized reporting metrics called "SMART COPD". I will complete these aims by working with my mentees to develop, test, and disseminate the "CHIMERA" and "SMART COPD" tools. CHIMERA will use a step-wise approach to identify HCD and IS domains and methods, followed by the use of logic models and concept mapping of stakeholder assessments from my R01 Aim 1 to develop a CHIMERA “cross walk” methodology that integrates both methods. CHIMERA will be tested in conjunction with my R01 Aims 2 and 3, implementation and post-implementation. The SMART COPD metrics will be developed using systematic literature review and a modified Delphi approach, in which our R01 team will identify and prioritize COPD TOC Program metrics to standardize reporting. This K24 will allow me to provide mentoring opportunities to my mentees through development of novel research tools. The enriched research program of my K24 entitled: "SMART POR: Supporting and Mentoring Across Respiratory Topics in Patient Oriented Research" will also provide ample opportunities for me to support current and future research mentees to implement research and drive investigator-based careers.

项目摘要 慢性阻塞性肺疾病 (COPD) 影响着超过 1600 万美国成年人，其中许多人 初次慢性阻塞性肺病后，急性护理复诊（急诊科和医院）的比率很高 这些频繁的病情加重通常是由于护理过渡 (TOC) 失败导致的。 需要进行大型多中心研究来解决目前存在的差距。 在大规模实施有效的 COPD TOC 之前，基本有效性和实施数据 我当前的 NHLBI R01 旨在解决这些差距。 通过在美国 20 家不同医院测试 COPD TOC 计划的有效性和实施情况来改善 为慢性阻塞性肺病 (COPD) 患者提供医疗保健服务和结果 My R01 同时使用实施。 科学（IS）和以人为本的设计（HCD）方法，虽然这些方法是严格和的。 互补的，以前瞻性的方式整合这些定性方法可以优化它们的潜力 影响干预措施的设计和实施，以获得数据并最终为护理提供信息 此外，标准化评估和报告 COPD TOC 计划的指标并重新审视。 数据可以显着改善 COPD TOC 项目和 K24 研究之间的结果。 将使我能够通过 R01 研究、指导计划和 开发、测试和传播综合 IS 和 HCD 定性和定量方法的基础设施 在面向患者的研究中使用我将与我的学员和 R01 研究团队专家在 IS 和 另外，我将合作开发一种名为“CHIMERA”的综合方法的 HCD 方法； 制定称为“SMART COPD”的统一报告指标，我将通过与我的合作来完成这些目标。 开发、测试和传播“CHIMERA”和“SMART COPD”工具的学员将使用 逐步确定 HCD 和 IS 领域和方法，然后使用逻辑模型和 利益相关者评估的概念图，来自我的 R01 目标 1，以开发 CHIMERA“人行横道” 集成这两种方法的方法将与我的 R01 目标 2 和 3 一起进行测试， SMART COPD 指标将采用系统化方法制定。 文献综述和修改后的德尔菲法，我们的 R01 团队将确定 COPD TOC 并确定其优先顺序 标准化报告的计划指标将使我能够为我的工作提供指导机会。 我的 K24 的丰富研究项目的标题是： “SMART POR：以患者为导向的研究中呼吸主题的支持和指导”还将 为我提供充足的机会来支持当前和未来的研究学员实施研究和 推动以调查员为基础的职业生涯。