A novel transducer clip-on device to enable accessible and functional 3D ultrasound imaging

一种新型换能器夹式装置，可实现易于使用且功能齐全的 3D 超声成像

基本信息

批准号：
10587466
负责人：
Pengfei Song
金额：
$ 54.79万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-30 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10587466
关键词：
3-Dimensional 3D ultrasound Ablation Acoustics Address Adoption Advanced Development Anatomy Area Axillary lymph node group Basic Science Benchmarking Benign Biopsy Blood Blood flow Breast Cancer Patient Cardiology Cellular Phone Clinic Clinical Clinical Research Clip Code Data Dependence Development Devices Diagnosis Diagnostic Discipline of obstetrics Equipment Foundations Frequencies Gynecology Illinois Image Imaging technology Intervention Ionizing radiation Malignant - descriptor Medical Medical Device Designs Motion Neoadjuvant Therapy Operative Surgical Procedures Pathology Patients Performance Phase Play Procedures Radiology Specialty Resolution Role Scanning Solid Speed System Techniques Technology Texas Three-Dimensional Imaging Time Tissues Training Transducers Ultrasonic Transducer Ultrasonography Universities Water Work base chemotherapy clinical application clinical imaging cost disease diagnosis elastography falls handheld equipment imaging modality imaging study imaging system improved in vivo light weight malignant breast neoplasm meetings non-invasive imaging novel portability radiologist sensor technology research and development tool ultrasound user-friendly wireless wireless communication

项目摘要

PROJECT SUMMARY/ABSTRACT Three-dimensional ultrasound imaging (3D-US) is an essential clinical tool for visualizing, navigating, and investigating patient anatomy and pathologies in real time in 3D. Owing to its moderate cost and lack of ionizing radiation, 3D-US plays an important role in many clinical applications for diagnosis and intervention. Despite the significant clinical value and potential, 3D-US is not a widely accessible and capable technology with its current implementations: existing 3D-US solutions are challenged by many limitations such as low imaging speed, low functionality, bulky devices that are inconvenient to use, and a high cost of designated equipment. For decades, there has been a long-standing quest for developing an accessible, functional, and user-friendly 3D-US technology. In this proposal, we will develop a new 3D-US solution (called FASTER) that uses a novel, fast-tilting microfabricated acoustic reflector to achieve high-speed and high-functionality 3D-US imaging. The acoustic reflector is water-immersible and enclosed in a clip-on device that is compact, lightweight, and low-cost. It can be easily attached to and removed from different types of ultrasound transducers to turn a conventional 2D ultrasound system into 3D. Unlike conventional 3D-US technologies (e.g., wobbler transducers and 2D matrix arrays), FASTER does not require the procurement of additional ultrasound transducers for different applications. Also, FASTER achieves a much higher imaging volume rate (up to 1000 Hz) than conventional 3D-US technologies. FASTER is compatible with most ultrasound systems on the market ranging from premium scanners to portable and handheld devices. In this proposal, we will conduct basic technology development research and carry out preliminary clinical studies to build a solid technical foundation for the FASTER 3D-US technology. In Aim 1 we will focus on developing the Phase-1 FASTER device that uses a double-axis reflector for extended range of imaging volume rate and field-of-view (FOV). We will also develop Phase-1 FASTER into a stand-alone device that does not need external equipment and communicates wirelessly with the ultrasound system. Aim 2 will focus on developing advanced imaging modes for FASTER, including 3D blood flow imaging (3D-BFI) and 3D shear wave elastography (3D-SWE). Pilot clinical studies will be conducted for both Aims 1 and 2 to facilitate the development and optimization of the FASTER device and imaging sequences. In Aim 3 we will conduct a clinical study to evaluate the performance of FASTER 3D-US in characterizing suspicious axillary lymph nodes (ALNs) for breast cancer patients undergoing clinically indicated biopsy of ALN. We will also evaluate the performance of FASTER in localizing clipped ALNs from patients undergoing neoadjuvant chemotherapy. The study aims will be carried out by a team of experts in ultrasound imaging, micro sensors and systems, medical device design, and breast cancer from the campuses of University of Illinois Urbana- Champaign, Texas A&M University, and Mayo Clinic.

项目概要/摘要三维超声成像 (3D-US) 是一种重要的临床工具，用于可视化、导航和诊断以 3D 方式实时研究患者的解剖结构和病理情况。由于其成本适中且缺乏电离辐射，3D-US 在诊断和干预的许多临床应用中发挥着重要作用。尽管 3D-US 具有显着的临床价值和潜力，但就目前的情况而言，它还不是一项可广泛使用且功能强大的技术实现：现有的3D-US解决方案受到许多限制的挑战，例如成像速度低、低功能单一、设备体积大、使用不方便、指定设备成本高。几十年来，长期以来，人们一直在寻求开发一种易于访问、功能齐全且用户友好的 3D-US 技术。在本提案中，我们将开发一种新的 3D-US 解决方案（称为 FASTER），该解决方案使用新颖的快速倾斜技术微加工声学反射器可实现高速、高性能的 3D-US 成像。声学反射器可浸入水中，并封装在紧凑、轻便且低成本的夹式装置中。它可以可以轻松地连接到不同类型的超声换能器上或从其上拆卸，从而将传统的 2D 超声系统进入 3D。与传统的 3D-US 技术（例如摆动传感器和 2D 矩阵阵列），FASTER 不需要为不同的应用采购额外的超声换能器。此外，与传统 3D-US 相比，FASTER 实现了更高的成像体积速率（高达 1000 Hz）技术。 FASTER 与市场上的大多数超声系统兼容，包括高级超声系统扫描仪到便携式和手持设备。在这个提案中，我们将进行基础技术开发研究并开展前期临床研究，为FASTER 3D-US奠定坚实的技术基础技术。在目标 1 中，我们将重点开发使用双轴反射器的 Phase-1 FASTER 设备用于扩展成像体积速率和视场 (FOV) 范围。我们还将把第一阶段的 FASTER 开发为独立设备，不需要外部设备并与超声波进行无线通信系统。目标 2 将专注于开发 FASTER 的先进成像模式，包括 3D 血流成像 (3D-BFI) 和 3D 剪切波弹性成像 (3D-SWE)。将为目标 1 和 2 促进 FASTER 设备和成像序列的开发和优化。在目标 3 中，我们将进行临床研究以评估 FASTER 3D-US 在表征可疑腋窝方面的性能接受临床指示的 ALN 活检的乳腺癌患者的淋巴结 (ALN)。我们还将评估 FASTER 在定位接受新辅助治疗的患者截断的 ALN 方面的性能化疗。该研究的目标将由超声成像、微传感器和伊利诺伊大学厄巴纳分校校园的系统、医疗设备设计和乳腺癌- 尚佩恩、德克萨斯农工大学和梅奥诊所。