Sensitivity enhancement of MRI with a Wireless Amplified NMR Detector

使用无线放大 NMR 探测器增强 MRI 的灵敏度

• 批准号: 8990836
• 负责人: Chunqi Qian
• 金额: $ 24.52万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8990836
• 关键词: Amplifiers; Award; Biomedical Research; Blood Vessels; Brain; Career Transition Award; Catheters; Chemicals; Chronic; Contrast Media; Coupling; Detection; Development; Devices; Diagnosis; Dimensions; Doctor of Philosophy; Elements; Faculty; Ferritin; Frequencies; Gadolinium DTPA; Goals; Heating; Image; Imagery; Implant; In Situ; Individual; Institution; International; Journals; Kidney; Laboratories; Lead; Magnetic Resonance; Magnetic Resonance Imaging; Mentors; Mentorship; Microfabrication; Microscopy; Monitor; Morphologic artifacts; Motion; National Institute of Neurological Disorders and Stroke; Nephrons; Organ; Penetration; Positioning Attribute; Power Sources; Preparation; Pump; Renal function; Renal tubule structure; Research; Research Personnel; Resolution; Risk; Rodent; Running; Signal Transduction; Source; Structure; Techniques; Technology; Time; Tissue Engineering; Tissues; United States National Institutes of Health; Wireless Technology; Work; abstracting; base; bioimaging; career; clinical Diagnosis; contrast imaging; design; detector; disease diagnosis; histological studies; imaging detector; improved; in vivo; innovation; kidney imaging; magnetic field; manganese chloride; member; millimeter; miniaturize; new technology; next generation; novel; object motion; radio frequency; symposium; temporal measurement; tool

Abstract: Dr. Chunqi Qian is applying for the K99/R00 career transition award in preparation for his immediate career goal to become an independent faculty member in an academic institution. Dr. Qian's long term career goal is to develop advanced detection technologies for the next generation MRI diagnosis with better sensitivity and accuracy. To achieve this goal, Dr. Qian has been continuously working in the research field of magnetic resonance for many years. His PhD thesis work was highlighted by the prestigious professional journal, the Journal of Magnetic Resonance, for his novel implementation of the wireless coupling technique in the construction of a variable angle MR detector. During his postdoctoral research at the National High Magnetic Field Laboratory, Dr. Qian successfully constructed a broad range tunable detector with good homogeneity and efficiency for the world's highest field MRI at 21.1 Tesla. This important progress has thus enabled the practical exploitation of high field magnet for biomedical imaging. This work has also been honored by the Young Investigator Award during the International Conference in Magnetic Resonance Microscopy. As a research fellow at NIH, Dr. Qian has for the first time developed a very promising technology that can greatly enhance the MRI detection sensitivity of internal organs, based on the innovative design concept of wireless amplified detection. This new technology has already been applied to obtain high resolution images of rodent kidney in vivo, enabling the detection of individual glomeruli and renal tubules. To further improve the imaging resolution, Dr. Qian will reduce the motional artifact by dynamically tracking the object motion with implanted detector itself, as is mentioned in Aim 1. To maximize the image contrast, Dr. Qian will use different contrast agents to visualize different components of nephron and correlate these high resolution images with histological studies, as is mentioned in Aim 2. These two specific aims will be accomplished under the mentorship of Dr. Alan Koretsky, during which time Dr. Qian will receive complete support from the NINDS. After Dr. Qian obtains an independent faculty position, he will continue the development of the wireless amplifier technology and exploit its biomedical applications. As is summarized in Aim 3, Dr. Qian will fabricate miniaturized wireless amplified detectors with microfabrication techniques. As is summarized in Aim 4, Dr. Qian will construct arrayed wireless detectors to get a bigger field-of-view, where each detector can be individually manipulated by a specific pumping signal. It is anticipated that further development of the wireless amplifier technology will lead to such applications as the chronic monitoring of engineered tissues and the in situ chemical sensing inside the digestive track.

摘要：Chunqi Qian博士正在申请K99/R00职业过渡奖，以准备 他成为学术机构的独立教师的直接职业目标。 Qian博士的长期职业目标是为下一个开发高级检测技术 具有更好敏感性和准确性的生成MRI诊断。为了实现这一目标，Qian博士已经 多年来一直在磁共振的研究领域工作。他的博士学位 论文工作由著名的专业杂志，《磁性杂志》强调 共鸣，他在构建中的无线耦合技术的新颖实施 可变角度MR检测器。在他在国家高磁性的博士后研究中 现场实验室，Qian博士成功地构建了一个良好的可调探测器 特斯拉21.1的世界最高现场MRI的同质性和效率。这很重要 因此，进步使对生物医学成像的高场磁铁的实际开发。 这项工作还获得了国际期间的年轻调查员奖 磁共振显微镜会议。作为NIH的研究员，Qian博士为 第一次开发了一种非常有前途的技术，可以大大增强MRI检测 基于无线扩增的创新设计概念的内部器官的敏感性 检测。这项新技术已经应用于获得高分辨率的图像 啮齿动物肾脏在体内，可以检测单个肾小球和肾小管。进一步 改善成像分辨率，Qian博士将通过动态跟踪减少运动伪像 如AIM 1所述，具有植入检测器本身的对象运动本身。 图像对比，Qian博士将使用不同的对比剂可视化不同的组件 肾单位并将这些高分辨率图像与组织学研究相关联 AIM 2。这两个具体目标将在Alan Koretsky博士的指导下实现 在此期间，Qian博士将获得Ninds的全部支持。 Qian博士获得后 一个独立的教师职位，他将继续开发无线放大器 技术并利用其生物医学应用。正如AIM 3中总结的，Qian博士将 使用微加工技术制造微型无线扩增检测器。原来 Qian博士在AIM 4中总结了，将构建阵列的无线探测器，以使更大 视野，其中每个检测器可以通过特定的抽水信号单独操纵。 预计无线放大器技术的进一步开发将导致这样 应用作为工程组织的长期监测和原位化学感应 在消化道内。