Hair Cortisol as a Biomarker of Chronic Early Life Stress

头发皮质醇作为慢性早期生活压力的生物标志物

• 批准号: 9043154
• 负责人: Amanda Tarullo
• 金额: $ 8.81万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9043154
• 关键词: 1 year old; 2 year old; Acute; Address; Adrenal Glands; Adult; Age; Area Under Curve; Biological; Biological Markers; Brain; Breast Feeding; Buffers; Caregivers; Caring; Child; Child Rearing; Chronic; Chronic stress; Data; Deposition; Development; Exposure to; Glare; Hair; Hair shaft structure; Health; Hormones; Hour; Household; Hydrocortisone; Hypothalamic structure; Infant; Intervention; Knowledge; Lead; Life; Life Stress; Link; Literature; Measures; Medical; Mental Health; Methodology; Methods; Nursery Schools; Outcome; Pathway interactions; Physiological; Pituitary Gland; Poverty; Predisposition; Preschool Child; Preventive Intervention; Process; Public Health; Regulation; Research; Research Personnel; Risk; Salivary; Sampling; Shapes; Sleep; Socioeconomic Status; Stress; System; Testing; Work; acute stress; base; cohort; daily functioning; design; early childhood; environmental stressor; expectation; experience; hypothalamic-pituitary-adrenal axis; improved; indexing; infancy; innovation; low socioeconomic status; physical conditioning; prevent; psychosocial; social; stressor

 DESCRIPTION: Children who experience chronic stress in early childhood are at risk for poor physical and mental health in adulthood. Early life stress shapes biological stress systems, with lifelong health consequences. Given the powerful long term implications of early life stress for public health, it is important to investigate how chronic early life stress exerts such far-reachin effects and which environmental stressors have the greatest impact on biological stress. Young children depend on sensitive caregivers to provide social buffering, protecting the developing brain from being exposed to too much of the stress hormone cortisol. However, poverty, household chaos, and parenting stress can disrupt this social buffering and may increase exposure to the stress hormone cortisol. To fully understand this process, a biological marker of chronic stress in infancy and early childhood is critically needed. Salivary cortisol, the most widely used marker of biological stress, measures acute rather than chronic stress, and salivary cortisol levels vary greatly from day to day. Cortisol is deposited in the hair shaft as it grows, o hair cortisol measures chronic stress over several months with a single sample. We and others have demonstrated the feasibility of measuring hair cortisol in young children. Yet much remains unknown about how this new method relates to established salivary cortisol methods. Salivary and hair measures may provide distinct information about the biological stress system, indexing daily regulation versus cumulative exposure. It is critical for researchers to make informed decisions about whether to use hair or salivary cortisol measures or both, as we work toward a comprehensive understanding of the processes through which early life stress influences biological stress systems. The current study will measure hair and salivary cortisol in 80 infants and 80 preschool children. Our first objective is to examine the extent to which hair cortisol and diurnal salivary cortisol measures are related in young children. Our second objective is to understand how established early life stressors relate to hair cortisol levels in young children. We will assess maternal sensitivity; maternal hair cortisol; maternal and paternal perceived stress; sleep; breastfeeding; childcare; fearfulness; household chaos; and socioeconomic status (SES) as predictors of this hair cortisol measure of chronic stress. This essential research will yield valuable data about how the innovative hair cortisol measure compares to ubiquitous salivary cortisol measures for two age cohorts, infancy and preschool, and how it relates to environmental stressors. Results will move the field forward in the quest to fully understand how early life stress shapes the development of biological stress systems. Ultimately, this knowledge will inform targeted prevention and intervention approaches to buffer young children from the biological consequences of early life stress, thus reducing long term public health burden.

 描述：幼儿期慢性压力的儿童面临成年后身体和心理健康不良的风险。早期生活压力塑造生物压力系统，并带来终生的健康后果。鉴于早期生活压力对公共卫生的有力长期影响，重要的是要研究慢性早期生活压力如何产生这种深远的影响力以及哪些环境压力对生物压力产生最大的影响。幼儿依靠敏感的护理人员提供社交缓冲，保护发育中的大脑免于暴露于太多的压力马匹皮质醇。但是，贫困，家庭混乱和育儿压力会破坏这种社交缓冲，并可能增加对马赛皮质醇的压力。为了充分理解这一过程，迫切需要在婴儿期和幼儿期的慢性压力的生物学标记。唾液皮质醇是生物胁迫最广泛使用的标志物，测量急性而不是慢性应激，而唾液皮质醇水平每天每天都有很大差异。皮质醇随着生长而沉积在脱发中，o毛皮质醇用单个样品在几个月内测量慢性应激。我们和其他人证明了测量幼儿头发皮质醇的可行性。然而，对于这种新方法与已建立的唾液皮质醇方法的关系仍然不清楚。唾液和头发测量值可能会提供有关生物应力系统的不同信息，从而索引日常调节与累积暴露。对于研究人员而言，至关重要的是，当我们致力于对早期生活压力影响生物压力系统的过程的全面理解时，就使用头发还是使用唾液皮质醇测量或两者兼而有之，这一点至关重要。当前的研究将测量80名婴儿和80名学龄前儿童的头发和唾液皮质醇。我们的第一个目标是检查幼儿皮质醇和不同的唾液皮质醇措施的程度。我们的第二个目标是了解与幼儿头发皮质醇水平相关的早期生活压力源是如何建立的。我们将评估产妇的敏感性； Matal头发皮质醇；母亲和父亲感知的压力；睡觉;哺乳;育儿；恐惧；家庭混乱；和社会经济状况（SES）作为慢性压力的头发皮质醇测量的预测因子。这项基本的研究将产生有关创新性皮质蛋白质测量的宝贵数据，与两个年龄群，婴儿期和学前班的无处不在的唾液皮质醇测量以及与环境压力的关系。结果将推动该领域向前发展，以完全了解早期压力如何塑造生物压力系统的发展。最终，这些知识将为有针对性的预防和干预方法提供帮助，以减轻幼儿的生物学压力，从而减少长期公共卫生伯恩的生物学后果。

项目成果

Chronic stress in the mother-infant dyad: Maternal hair cortisol, infant salivary cortisol and interactional synchrony.

• DOI: 10.1016/j.infbeh.2017.03.007
• 发表时间: 2017-05
• 期刊: Infant behavior & development
• 影响因子: 2.1
• 作者: Tarullo AR;St John AM;Meyer JS
• 通讯作者: Meyer JS

Infant diurnal cortisol predicts sleep.

婴儿昼间皮质醇可预测睡眠。

• DOI: 10.1111/jsr.13357
• 发表时间: 2021
• 期刊: Journal of sleep research
• 影响因子: 4.4
• 作者: Tuladhar,CharuT;Schwartz,Sophie;StJohn,AshleyM;Meyer,JerroldS;Tarullo,AmandaR
• 通讯作者: Tarullo,AmandaR

Social Fear in US Infants: The Roles of Hair and Salivary Cortisol.

美国婴儿的社交恐惧：头发和唾液皮质醇的作用。

• 发表时间: 2022
• 期刊: The Yale journal of biology and medicine
• 作者: Winebrake,DeavenA;Almeida,CarlosF;Tuladhar,CharuT;Kao,Katie;Meyer,JerroldS;Tarullo,AmandaR
• 通讯作者: Tarullo,AmandaR

Parental and Family-Level Sociocontextual Correlates of Emergent Emotion Regulation: Implications for Early Social Competence.

• DOI: 10.1007/s10826-020-01706-4
• 发表时间: 2020-06
• 期刊: Journal of child and family studies
• 影响因子: 2.1
• 作者: Kao K;Tuladhar CT;Tarullo AR
• 通讯作者: Tarullo AR

Maternal cortisol slope at 6 months predicts infant cortisol slope and EEG power at 12 months.

6 个月时的母亲皮质醇斜率可预测 12 个月时的婴儿皮质醇斜率和脑电图功率。

• DOI: 10.1002/dev.21540
• 发表时间: 2017
• 期刊: Developmental psychobiology
• 影响因子: 2.2
• 作者: StJohn,AshleyM;Kao,Katie;Liederman,Jacqueline;Grieve,PhilipG;Tarullo,AmandaR
• 通讯作者: Tarullo,AmandaR