Biomarkers of Insufficient Sleep and Sleepiness

睡眠不足和困倦的生物标志物

基本信息

批准号：
9082143
负责人：
Nichole A Reisdorph
金额：
$ 61.19万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-20 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9082143
关键词：
Academy Accidents Address Administrative Supplement Advisory Committees Affect American Anxiety Automobile Driving Award Biological Markers Blood Chronic Circadian Rhythms Clinic Clinical Clinical Treatment Cognition Cognitive Data Diabetes Mellitus Diagnostic Disease Drowsy Driving Drug abuse Engineering Environment Epidemic Fatigue Goals Health Health Personnel Healthcare Homeostasis Hour Impairment Individual Inflammation Inflammatory Joints Laboratories Lipids Measures Medical Medicine Mental Depression Metabolic Military Personnel Monitor Obesity Occupations Outcome Performance Personal Satisfaction Phase Phenotype Plasma Polysomnography Population Precision Medicine Initiative Protocols documentation Public Health Quality of life Reporting Research Research Training Risk Safety Schedule Scientist Short-Term Memory Side Sleep Sleep Disorders Societies Staging Stress Task Performances Testing Time Training Translations Transportation Treatment outcome Triglycerides United States National Institutes of Health Visual attention Wakefulness Work base biomarker development biomarker discovery candidate marker clinical biomarkers cognitive performance cohort design diagnostic biomarker executive function fitness improved lipid metabolism metabolomics post-doctoral training potential biomarker primary outcome public health relevance response secondary outcome small molecule vigilance

项目摘要

DESCRIPTION (provided by applicant): Sleep and wakefulness disorders impact 50 to 70 million Americans and insufficient sleep is epidemic with over 50% of Americans reporting less than 7 hours of sleep per night. Health problems associated with insufficient sleep include inflammation, depression and anxiety, diabetes, stress, drug abuse, poor quality of life, obesity, and fatigue related accidents on the job/while driving. While the contribution of sleep to overall health, well-being, and public safety is recognized, no established clinical biomarkers of sleep deficiency exist. Such biomarkers would have utility as road-side biomarkers of sleepiness (e.g., drowsy driving), monitoring on the job fatigue/fitness for duty (e.g., transportation, military ops health care), monitoring sleep health, as well as for clinical diagnostics and measures of clinical treatment outcomes. Thus, we designed a controlled laboratory insufficient sleep protocol utilizing metabolomics to identify biomarkers of insufficient sleep. Preliminary metabolomics data from our NIH Administrative Supplement awarded to our existing R01 "Metabolic and Cognitive Consequences of Sleep Loss" set the stage for this proposal and facilitated our proposed discovery and targeted approaches. The current proposal is responsive to key goals of the 2014 Joint Task Force of the Sleep Research Society and American Academy of Sleep Medicine report. We propose to identify changes in metabolites that consistently occur during insufficient sleep. We will also target metabolites identified by our previous research efforts as potential biomarkers. As an exploratory outcome we will examine associated changes in metabolites and cognitive performance during insufficient sleep. These proposed outcomes support the NIH Precision Medicine Initiative and the 2011 NIH Sleep Disorders Research Plan to identify biomarkers of sleep deficiency and enabling sleep and circadian research training in cross-cutting domains to accelerate the pace of discovery and translation.

描述（由申请人提供）：睡眠和觉醒障碍影响着 50 至 7000 万美国人，睡眠不足是一种普遍现象，超过 50% 的美国人报告每晚睡眠不足 7 小时，包括炎症、抑郁和焦虑。虽然睡眠对整体健康、福祉和公共安全的贡献已得到认可，但尚无确定的临床生物标志物。睡眠不足此类生物标记物可用作路边困倦生物标记物（例如，疲劳驾驶）、监测工作疲劳/适合值班（例如，交通、军事行动医疗保健）、监测睡眠健康以及临床。临床诊断和测量因此，我们设计了一个受控实验室睡眠不足方案，利用代谢组学来识别睡眠不足的生物标志物，这些数据来自我们授予我们现有的 R01“睡眠不足的代谢和认知后果”的 NIH 行政补充资料。并促进了我们提出的发现和有针对性的方法，当前的提案响应了 2014 年睡眠研究协会和美国睡眠医学会联合工作组报告的主要目标。我们建议确定睡眠不足期间持续发生的代谢物变化，我们还将把我们之前的研究工作确定的代谢物作为潜在的生物标志物，作为探索性结果，我们将检查睡眠不足期间代谢物和认知表现的相关变化。支持 NIH 精准医学计划和 2011 年 NIH 睡眠障碍研究计划，以确定睡眠不足的生物标志物，并在跨领域开展睡眠和环昼夜研究培训，以加快发现和转化的步伐。