Latino

拉丁裔

基本信息

批准号：
10615172
负责人：
Tamar Gollan
金额：
$ 23.98万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10615172
关键词：
Address African American population Aging Agreement Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Area Attitude Autopsy Awareness Behavioral Biological Markers Birth Brain California Cardiovascular system Caring Clinic Clinical Clinical Research Clinical Trials Clinical assessments Cognition Cognitive Communities County Data Set Databases Dementia Development Diagnosis Disease Disparity population Early Diagnosis Early treatment Education Effectiveness Elderly Enrollment Ensure Environment Epidemiology Exposure to General Practitioners Genetic Health Healthcare Hispanic Insurance Investigation Knowledge Language Latino Latino Population Life Expectancy Linguistics Memory Metabolic Methods Mexican Americans Names Neurocognitive Neurologic Neuropsychology Participant Patients Persons Physicians Population Positioning Attribute Procedures Program Evaluation Reduce health disparities Registries Reporting Research Research Personnel Research Project Grants Research Support Role Sampling Screening procedure Services Spinal Puncture Study of Latinos Subgroup Testing Underserved Population United States National Institutes of Health Validation Work age related base bilingualism brain health burden of illness care burden caucasian American clinical center clinical outcome measures cognitive change cognitive testing cohort diagnostic tool disparity reduction education research health disparity innovation interest mild cognitive impairment neuroimaging novel outreach pre-clinical recruit research study screening social disparities tool willingness

项目摘要

LATINO CORE - SUMMARY/ ABSTRACT Alzheimer’s disease and related dementias (ADRD) among U.S. Latinos are projected to increase over nine-fold from 379,000 in 2012 to 3.5 million by 2060. Latinos represent 18% of the U.S. population and about 40% of the population of California. Latinos lag behind Whites and African-Americans in education and healthcare insurance, and have cardiovascular, metabolic, and other disease burdens that exceed those of Whites; however, Latino life-expectancy at birth surpasses that of Whites by over 3-years giving them greater exposure to age-related risk of ADRD. Because of these factors, and cultural differences in reporting behavioral, cognitive, and functional deficits, state-of-the-art clinical, neuropsychological, and neurological procedures used to diagnose AD, that were largely developed and validated in relatively homogeneous, well- educated, White, English-speaking populations, may not work effectively with monolingual Spanish-speaking or Spanish-English bilingual older Latinos. Thus, there is a need for AD-related research in older Latinos to overcome barriers to effective screening, assessment, diagnosis and treatment of early and preclinical disease. There is also a need to better understand factors that impede or facilitate participation of elderly Latinos (particularly Mexican-Americans) in AD-related research, including awareness of AD and its clinical features, level of concern about the consequences of AD and burden of care, and willingness to participate in research including procedures such as sampling of biomarkers, genetics, and autopsy. To address these needs, the overall aims of the Latino Core are to: 1) conduct a linguistically- and culturally-appropriate memory screening and evaluation program in predominantly Latino areas in San Diego to develop and maintain a registry of well-characterized older Latino individuals who are interested in research and have agreed to be contacted about on-going AD-related research studies; 2) conduct developmental research to refine and evaluate linguistically- and culturally-appropriate clinical and cognitive assessment procedures to accurately identify MCI and the transition to AD dementia in older Latinos; 3) conduct developmental research to determine degree of knowledge and attitudes towards AD, brain health, and participation in all aspects of AD research in older Latinos; and 4) serve as a conduit between the activities of the ADRC and a large-scale epidemiology project on cognitive changes in older Latinos known as the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) and other new national and state-wide Latino research initiatives. This will allow participants identified with possible Mild Cognitive Impairment or ADRD to receive more extensive clinical and neuropsychological characterization and to participate in AD-related research projects, including clinical trials. Thus, the Latino Core will ensure that the ADRC is well positioned to study ADRD in this significant yet underserved population, filling critical gaps in scientific knowledge essential for reducing the disparities related to ADRD diagnosis, treatment and care facing Latinos in our San Diego community and beyond.

拉丁美洲核心 - 总结/摘要美国拉丁裔中阿尔茨海默病和相关痴呆症 (ADRD) 的患病率预计将在从 2012 年的 379,000 人增加到 2060 年的 350 万，增长了九倍。拉丁美洲人占美国人口的 18%，约占加州 40% 的拉丁裔人口在教育和教育方面落后于白人和非裔美国人。拥有医疗保险，且心血管、代谢和其他疾病负担超过普通人然而，拉丁裔的出生时预期寿命比白人长 3 年多，这使他们的寿命更长由于这些因素以及报告中的文化差异，暴露于与年龄相关的 ADRD 风险。行为、认知和功能缺陷，最先进的临床、神经心理学和神经病学用于诊断 AD 的程序，主要是在相对同质、良好的环境中开发和验证的。受过教育的白人、讲英语的人群可能无法与只讲西班牙语的人有效地合作或西班牙语-英语双语老年拉丁裔因此，需要对老年拉丁裔进行 AD 相关研究。克服早期和临床前有效筛查、评估、诊断和治疗的障碍还需要更好地了解阻碍或促进老年人参与的因素。拉丁裔（尤其是墨西哥裔美国人）参与 AD 相关研究，包括对 AD 及其临床的认识特征、对 AD 后果的关注程度和护理负担以及参与的意愿研究包括生物标志物采样、遗传学和尸检等程序来解决这些问题。需求，拉丁裔核心的总体目标是：1）进行语言和文化上适当的记忆在圣地亚哥以拉丁裔为主的地区开展筛查和评估计划，以制定和维持对研究感兴趣并同意加入的具有良好特征的老年拉丁裔个人的登记册联系正在进行的 AD 相关研究；2) 进行发展研究以完善和评估语言和文化上适当的临床和认知评估程序，以准确地确定老年拉丁美洲人的 MCI 和 AD 痴呆的转变 3) 进行发展研究；确定对AD、大脑健康以及参与AD各个方面的知识和态度的程度对老年拉丁裔的研究；以及 4) 作为 ADRC 和大规模活动之间的桥梁。关于老年拉丁裔认知变化的流行病学项目，称为拉丁裔研究 - 调查神经认知老化（SOL-INCA）和其他新的国家和全州拉丁裔研究计划。允许被确定患有轻度认知障碍或 ADRD 的参与者接受更广泛的临床和神经心理学表征并参与 AD 相关研究项目，包括临床因此，拉丁美洲核心将确保 ADRC 处于有利位置来研究 ADRD 这一重大但尚未完成的任务。服务不足的人口，填补科学知识的关键空白，这对于减少相关差距至关重要圣地亚哥社区及其他地区拉丁裔面临的 ADRD 诊断、治疗和护理。