Analytic Core
分析核心
基本信息
- 批准号:9207387
- 负责人:
- 金额:$ 55.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AIDS preventionAccountingAddressAdolescentAlgorithmsBehaviorBehavioral ResearchBiologicalBiological MarkersBisexualCar PhoneCaringClinicCommunitiesComorbidityComplexComputer softwareConsultConsultationsCost Effectiveness AnalysisDataData AnalysesData CollectionData QualityData SecurityData Storage and RetrievalDevelopmentDrug usageElectronicsEnrollmentEnsureEvaluation StudiesGaysHIVHIV InfectionsHIV riskHealth Insurance Portability and Accountability ActHomeless YouthHomelessnessHot SpotInformation DisseminationInterventionLeadLeadershipMapsMental HealthMethodsModelingOnline SystemsOutcomeOutcome AssessmentOutcome MeasurePaperParticipantPatient Self-ReportPreventionPrevention strategyProtocols documentationPublicationsRandomizedRandomized Controlled TrialsRecruitment ActivityResearchResearch DesignResearch PersonnelResearch PriorityResearch SupportRiskRisk FactorsSamplingScientistServicesSiteSocial WorkSpottingsStatistical MethodsTechnologyTimeUnited States National Institutes of HealthUrsidae FamilyWorkWritingYouthabstractingbasebehavioral outcomecare deliverycloud basedcostcost effectivenessdata managementexperiencehigh riskimplementation scienceinnovationinterestmultilevel analysissocial mediasocial networking websitestandard of caretooltransgendertransmission processtreatment strategyweb portal
项目摘要
Project Summary/Abstract
Adolescent HIV interventions call for more advanced analytic approaches than traditional HIV studies have
used. HIV prevention and treatment research trials have traditionally been conducted in a randomized
controlled trial (RCT) framework where study participants, often recruited from social service agencies, are
randomized into an intervention or standard of care condition and followed over time. Outcome measures
consist of self-reported mental health and HIV transmission behaviors. Three large changes are necessary for
adolescent studies in the modern era of HIV research. First, youth are often difficult to identify and engage in
HIV care. Innovative recruitment strategies that make use of traditional and technology-based methods are
necessary to maximize efforts. Second, NIH research priorities target biomedical HIV endpoints. Combination
strategies that target HIV end points and comorbid conditions are needed. Lastly, researchers need to plan for
intervention delivery in real-world settings. Youth deal with many complex issues, such as homelessness, that
can impede access to and delivery of care, directly impacting biological outcome markers. Studies in the
proposed U19 proposal will address current challenges in HIV research by using comprehensive youth
engagement strategies and combination prevention strategies to address HIV end points and comorbidities.
Statistical methods will be used to evaluate interventions in the RCT framework through complex multilevel
models (MLM) to evaluate multiple end points over time. In addition, implementation science methods will be
used to examine barriers to HIV care and engagement in clinic settings.
The Analytic Core provides a range of technological, biomedical, and behavioral research expertise that will
support research in the current U19 proposal. The Analytic Core is comprised of statisticians with expertise in
fitting complex MLM in HIV studies that contain both biomarker and behavioral outcomes. Technologists are
also a part of the Core and have used social media recruitment tools, mobile phone-based assessment, and
cloud-based data storage in their own HIV research. The Analytic Core also fields expertise in implementation
science and cost effectiveness analysis that will be used to address study aims. The Analytic Core will support
research across U19 projects through the following specific aims. First, we will provide consultation on web-
based tools that will enhance standard recruitment methods and finalize the recruitment sample of
seronegative youth based on risk factors from a larger pool of seronegative youth. Second, data collection will
be centralized to maximize data quality and security, minimize costs, and facilitate analysis. Dimagi
CommCare software that we have used in prior HIV research will be used and provides an integrated package
to provide HIPAA-compliant cloud-based data storage and mobile phone or web-based data entry. Third, Core
scientists will conduct innovative analyses that include biological, engagement, and behavioral outcomes.
Lastly, the Analytic Core will coordinate with the Management Core for timely dissemination of study findings.
项目摘要/摘要
青春期的HIV干预措施要求比传统的HIV研究更高级分析方法
用过的。传统上是在一个随机的
对照试验(RCT)框架,在社会服务机构经常招募的研究参与者是
随机分为干预措施或护理条件,随着时间的推移。结果措施
由自我报告的心理健康和HIV传播行为组成。需要三个大变化
艾滋病毒研究时代的青少年研究。首先,年轻人通常很难识别和参与
艾滋病毒护理。利用传统和基于技术方法的创新招聘策略是
最大化努力所必需的。其次,NIH研究优先级针对生物医学HIV终点。组合
需要针对HIV终点和合并条件的策略。最后,研究人员需要计划
在现实世界中的干预交付。青年处理许多复杂问题,例如无家可归,
可以阻碍获得和提供护理的机会,直接影响生物学结果标记。研究
拟议的U19提案将通过使用全面的青年来解决HIV研究中当前挑战
参与策略和预防策略,以解决艾滋病毒终点和合并症。
统计方法将用于通过复杂的多级别评估RCT框架中的干预措施
随着时间的推移,模型(MLM)评估多个端点。此外,实施科学方法将是
用于检查临床环境中艾滋病毒护理和参与的障碍。
分析核心提供了一系列技术,生物医学和行为研究专业知识
支持当前U19提案中的研究。分析核心由具有专业知识的统计学家组成
在艾滋病毒研究中拟合复杂的MLM,其中包含生物标志物和行为结果。技术人员是
也是核心的一部分,并使用了社交媒体招聘工具,基于手机的评估和
基于云的数据存储在自己的艾滋病毒研究中。分析核心还规定了实施方面的专业知识
科学和成本效益分析将用于解决研究目标。分析核心将支持
通过以下特定目的进行U19项目的研究。首先,我们将提供有关网络的咨询
将增强标准招聘方法并最终确定招聘样本的基于工具
基于较大的血清神经青年的危险因素的血清阴性青年。第二,数据收集将
集中以最大化数据质量和安全性,最大程度地减少成本并促进分析。 Dimagi
我们将在先前的HIV研究中使用的Commcare软件将使用并提供集成软件包
提供符合HIPAA的基于云的数据存储和手机或基于Web的数据条目。第三,核心
科学家将进行创新的分析,包括生物学,参与和行为结果。
最后,分析核心将与管理核心协调研究结果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Warren Scott Comulada其他文献
Warren Scott Comulada的其他文献
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{{ truncateString('Warren Scott Comulada', 18)}}的其他基金
An mHealth platform for health care workers to link South Africans to HIV care
医疗保健工作者的移动医疗平台,将南非人与艾滋病毒护理联系起来
- 批准号:
9134211 - 财政年份:2015
- 资助金额:
$ 55.75万 - 项目类别:
Predicting HIV-related Behaviors of Social Networks in a MPS Environment
预测 MPS 环境中社交网络的 HIV 相关行为
- 批准号:
8012085 - 财政年份:2010
- 资助金额:
$ 55.75万 - 项目类别:
Predicting HIV-related Behaviors of Social Networks in a MPS Environment
预测 MPS 环境中社交网络的 HIV 相关行为
- 批准号:
8309291 - 财政年份:2010
- 资助金额:
$ 55.75万 - 项目类别:
Predicting HIV-related Behaviors of Social Networks in a MPS Environment
预测 MPS 环境中社交网络的 HIV 相关行为
- 批准号:
8530281 - 财政年份:2010
- 资助金额:
$ 55.75万 - 项目类别:
Predicting HIV-related Behaviors of Social Networks in a MPS Environment
预测 MPS 环境中社交网络的 HIV 相关行为
- 批准号:
8727096 - 财政年份:2010
- 资助金额:
$ 55.75万 - 项目类别:
Predicting HIV-related Behaviors of Social Networks in a MPS Environment
预测 MPS 环境中社交网络的 HIV 相关行为
- 批准号:
8145638 - 财政年份:2010
- 资助金额:
$ 55.75万 - 项目类别:
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