Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers

年轻成人低频吸烟者对减少尼古丁香烟的反应

• 批准号: 9194369
• 负责人: Francis Joseph McClernon
• 金额: $ 43.48万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9194369
• 关键词: Abstinence; Acute; Address; Adolescent; Adolescent and Young Adult; Adult; Affect; Age; Cigarette; Cotinine; Dependence; Dizziness; Dose; Double-Blind Method; Evaluation; Family Smoking Prevention and Tobacco Control Act; Frequencies; Goals; Health; Individual; Logistic Regressions; Methods; Nicotine; Nicotine Dependence; Participant; Pattern; Plasma; Public Health; Randomized; Reaction; Regression Analysis; Reporting; Research; Risk; Role; Sampling; Self-Administered; Series; Smoke; Smoker; Smoking; Smoking Behavior; Testing; Time; Tobacco; Tobacco Dependence; Tobacco smoke; Tobacco use; Toxicant exposure; authority; cigarette smoking; experience; improved; population health; reduce tobacco use; research study; sex; young adult

Passage of the Family Smoking Prevention and Tobacco Control Act in 2009 provides the FDA with regulatory authority to reduce the nicotine content of cigarettes if doing so will result in improved population health. Accumulating evidence suggests that reducing nicotine content in cigarettes reduces smoking behavior and toxicant exposure among adult daily, dependent smokers. However, such research leaves open the question of the effects of nicotine reduction on experimentation with cigarettes among adolescents and young adults at risk for progression to regular use and dependence. This is an important question since a nicotine content that reduces tobacco use and dependence among daily smokers could conceivably support continued experimentation and progression to dependence among non-daily smokers. The overarching goal of the proposed research is to evaluate reactions to, and choices to self-administer, cigarette smoke with varying nicotine content among low-frequency, non-dependent adolescent/young adult smokers between the ages of 18-25 yrs. The proposed sample (n=90) approximates the age and smoking patterns of individuals experimenting with cigarettes and as such, will provide critical information about the role of nicotine content in promoting and sustaining continued experimentation and progression to use. Participants will undergo three sessions in which their reactions to fixed doses of smoke from investigational cigarettes with three different nicotine contents (15.8 mg/gram of tobacco, 2.5 mg/g, and .4 mg/g). Following the third fixed-dose session, participants will return to the lab to choose one of the cigarettes to self-administer. Order of the fixed-dose sessions will be counterbalanced and randomly assigned; all tests will be conducted double-blind. We hypothesize that intermediate nicotine content cigarettes will produce greater positive reactions than very low nicotine content cigarettes and less negative reactions than normal nicotine content cigarettes. Participants will choose to self-administer intermediate content cigarettes over the others. The proposed research will provide an evaluation of the amount of nicotine in cigarette smoke that produces reactions associated with progression from initial smoking to nicotine dependence in a sample representative of individuals experimenting with cigarette use. Specifically, observing that a nicotine content level (2.4 mg/g) that reduces smoking among dependent, daily smokers, results in reactions and choices that are associated with progression to regular smoking and dependence, can have a significant impact in establishing new cigarette product standards.

2009年，《家庭预防吸烟和烟草控制法》的通过为FDA提供了监管 如果这样做的话，则授权减少香烟的尼古丁含量，从而改善人口健康。 积累的证据表明，减少香烟中的尼古丁含量会减少吸烟行为和 成人每日吸烟者的毒性暴露。但是，这样的研究留下了一个问题 尼古丁减少对青少年和年轻人在香烟实验的影响 有规律使用和依赖的风险。这是一个重要的问题，因为尼古丁含量 减少日常吸烟者中的烟草使用和依赖性可能会继续支持 非每日吸烟者的实验和对依赖性的发展。总体目标 拟议的研究是评估对自我管理的反应和选择，香烟烟雾有所不同 低频，非依赖青少年/年轻人吸烟者之间的尼古丁含量 18-25岁。提出的样本（n = 90）近似个体的年龄和吸烟方式 尝试香烟，因此将提供有关尼古丁含量在中的作用的关键信息 促进和维持持续的实验和进展。参与者将经历三个 他们对研究性香烟的固定剂量烟雾的反应与三种不同的烟雾 尼古丁含量（15.8 mg/gr烟草，2.5 mg/g和.4 mg/g）。遵循第三次固定剂量会话， 参与者将返回实验室，选择其中一种香烟来自我管理。固定剂量的顺序 会议将是平衡和随机分配的；所有测试将进行双盲。我们 假设中间尼古丁含量香烟会产生比非常低的阳性反应 尼古丁含量的香烟和尼古丁含量香烟的负面反应少。参与者会 选择自我管理中间内容的香烟。拟议的研究将提供 评估烟烟中尼古丁的数量，产生与进展相关的反应 从初始吸烟到代表实验的个体的样本中的尼古丁依赖性 使用香烟。具体而言，观察到尼古丁含量水平（2.4 mg/g）可以减少吸烟 依赖的每日吸烟者会导致与正常发展有关的反应和选择 吸烟和依赖性可能会对建立新的香烟产品标准产生重大影响。