Pressure and Temperature Monitoring and Regulating Insole

压力和温度监测和调节鞋垫

• 批准号: 9254119
• 负责人: GORDON B HIRSCHMAN
• 金额: $ 22.5万
• 依托单位: VIVONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9254119
• 关键词: Address; Adverse effects; Amputation; Animals; Applications Grants; Biological Markers; Biomechanics; Blood Circulation; Characteristics; Chemistry; Clinical Research; Decubitus ulcer; Devices; Diabetes Mellitus; Diabetic Foot; Diabetic Foot Ulcer; Diabetic Neuropathies; Elements; Esthesia; Etiology; Foot Ulcer; Future; Goals; Health; Healthcare Systems; Heating; Individual; Inflammatory; Injury; Ischemia; Lead; Left; Measures; Mechanics; Medicine; Metabolic; Methods; Monitor; Neuropathy; Pathology; Patient Monitoring; Patients; Phase; Phase Transition; Physical activity; Pilot Projects; Population; Property; Quality of life; Reporting; Research Personnel; Rest; Shoes; Skin; Skin Temperature; Small Business Innovation Research Grant; Specific qualifier value; Stress; Surface; System; Technology; Temperature; Testing; Texas; Textiles; Therapeutic; Therapeutic Effect; Thick; Time; Tissues; Transition Temperature; Ulcer; Universities; Walking; Work; base; clinical efficacy; cost; density; design; diabetic; diabetic patient; experience; foot; heating technology; human subject; in vivo; meetings; musculoskeletal injury; natural hypothermia; novel; phase change; physical model; pressure; prevent; programs; sensor; shear stress; success; tool; treadmill

PROJECT SUMMARY/ABSTRACT Diabetic foot ulceration has a complicated biomechanical pathology that involves not only plantar pressure but also shear stresses and physical activity, among other factors. A number of pressure ulcer studies have also demonstrated that warmer tissue is more vulnerable to breakdown when compared to cooler tissue. Diabetic ulceration and related amputations impairs quality of life and also is incredibly costly to the patient and to the US healthcare system, costing an estimated $30 billion dollars annually. Although the etiology of diabetic foot ulcers is still debated, pressure, shear, and temperature are all thought to be contributing factors. In this grant application, Vivonics and University of North Texas seek to develop new footwear that will monitor key biomarkers (pressure and temperature) that can report early tissue damage before it is clinically apparent and also counter pressure peaks and regulate temperature using a novel cooling/heating technology. This technology can later be utilized to assess the clinical efficacy of regulating temperature in preventing foot ulcers. Prior studies have shown that cooling the plantar surface can reduce skin breakdown and ulceration. Availability of a system that can be worn for long periods of time and can monitor plantar temperature and pressure, reduce pressure peaks and control the plantar temperature will enable researchers to conduct in vivo studies to explore the efficacy of a widely accepted therapeutic method (i.e., hypothermia) in diabetic ulceration. In the future this tool may also be used as a prescribed therapeutic insole for the diabetic population.

项目摘要/摘要 糖尿病足溃疡具有复杂的生物力学病理学，不仅涉及足底压力，而且还涉及 剪切应力和体育锻炼以及其他因素。许多压溃疡研究也 证明与较冷的组织相比，较温暖的组织更容易受到破坏的影响。糖尿病 溃疡和相关的截肢会损害生活质量，对患者和美国的成本也很高 医疗保健系统，估计每年耗资300亿美元。虽然糖尿病足溃疡的病因 仍认为仍有争议，压力，剪切和温度都是促成因素。 在此赠款申请中，Vivonics和North Dexas大学寻求开发新的鞋类，以监视 可以在临床明显之前报告早期组织损伤的关键生物标志物（压力和温度） 还使用新型的冷却/加热技术来对抗压力峰并调节温度。这 以后可以利用技术来评估调节温度在防止足溃疡中的临床功效。 先前的研究表明，冷却足底可以减少皮肤破裂和溃疡。 可以长时间佩戴的系统的可用性，可以监视足底温度和 压力，降低压力峰并控制足底温度将使研究人员能够在体内进行 探索广泛接受的治疗方法（即低温）在糖尿病性溃疡中的疗效的研究。 将来，该工具也可以用作糖尿病人群的处方治疗鞋垫。