Role of chemokines in neuronal function and survival

趋化因子在神经元功能和存活中的作用

• 批准号: 10610620
• 负责人: Olimpia Meucci
• 金额: $ 48.33万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10610620
• 关键词: Adult; Animal Model; Award; Back; Brain; CXCR4 Receptors; CXCR4 gene; Cells; Central Nervous System; Cognition; Cognitive deficits; Collaborations; Complement; Complex; Electrophysiology (science); Event; Future; HIV; HIV-associated neurocognitive disorder; Human; Image; Impaired cognition; Individual; Inflammation Mediators; Interneurons; Knowledge; Ligands; Measures; Medial; Mediating; Modeling; Molecular; Monitor; Morphine; Neuroglia; Neurons; Neurosurgeon; Neurotoxins; Opioid; Opioid Receptor; Opioid agonist; Outcome; Pathway interactions; Population; Prefrontal Cortex; Process; Proteins; Rattus; Regulation; Rodent; Role; Signal Transduction; Site; Slice; Somatostatin; Stimulus; Stromal Cell-Derived Factor 1; Substance Use Disorder; Synapses; Synaptic plasticity; Techniques; Testing; Therapeutic; Tissues; Transgenic Model; Transgenic Organisms; Vertebral column; Viral Proteins; Work; behavioral study; chemokine; chemokine receptor; hippocampal pyramidal neuron; improved; in vivo; inhibitory neuron; interest; knock-down; multi-electrode arrays; neuroAIDS; neurocognitive test; neuroprotection; opioid use; optogenetics; receptor; recruit; therapeutic evaluation; translational applications; two photon microscopy; validation studies