Mentoring in Musculoskeletal Pain Phenotypes

肌肉骨骼疼痛表型的指导

基本信息

批准号：
10610421
负责人：
Adam Goode
金额：
$ 18.68万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-15 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10610421
关键词：
Acute Address Affect Area Award Biochemical Biological Biological Markers Biomechanics Career Mobility Cartilage Chronic Chronic low back pain Clinic Clinical Clinical Research Clinical Sciences Collaborations Communities Complement Data Data Science Development Direct Costs Discipline Disease Educational process of instructing Electronic Health Record Ensure Environment Epidemiology Facilities and Administrative Costs Fostering Funding Generations Goals Health Health system Healthcare Healthcare Systems Heterogeneity High Prevalence Image Intervertebral disc structure Knee Osteoarthritis Learning Low Back Pain Mechanics Mentors Mentorship Methodology Methods Midcareer Investigator Award in Patient-Oriented Research Musculoskeletal Musculoskeletal Pain Occupational Therapy Orthopedic Surgery Outcome Pain Pain Research Pain management Patients Persons Phenotype Physical therapy Physicians Prevalence Process Productivity Quality of life Request for Applications Research Research Design Research Infrastructure Research Institute Research Methodology Research Personnel Research Project Grants Resources Risk Reduction Role Scientist Serum Societies Sociology Strategic Planning Time Training Training Programs Translational Research United States United States National Institutes of Health Universities Urine Vertebral column Wages Work career career development chronic musculoskeletal pain chronic pain chronic painful condition clinical care clinical implementation clinical pain clinical phenotype clinically significant collaboratory cost design experience health care service utilization innovation medical schools meniscus injury mid-career faculty multidisciplinary next generation opioid epidemic pain chronification patient oriented research population health pragmatic trial predictive marker prevent programs psychologic rehabilitation research skill acquisition skills systems research tool trial design years lived with disability

项目摘要

PROJECT SUMMARY/ ABSTRACT This is a submission for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Adam Goode, is a clinician-scientist and Associate Professor in the Duke University Department of Orthopedic Surgery. Throughout his career, Dr. Goode has worked on epidemiological and mechanistic studies to better understand the heterogeneity that exists with low back pain and musculoskeletal conditions. These studies use advanced imaging and biochemical biomarkers found in serum and urine to characterize disease status and progression. These efforts have resulted in a current R01 Mechanical Biomarkers of Chronic Low Back Pain (AR075399) on advanced imaging of the intervertebral disc to characterize the role of mechanical strain with low back pain and a recently funded R01 Biological and Biomechanical Predictors of Cartilage Health Following Meniscus Injury (AR079184). These activities and projects engage a broad multidisciplinary team focused on advancing our understanding of low back pain, spine and knee OA in patient oriented research. The current application requests funding (50% salary support) for 5 years to support the protected time necessary to conduct the proposed patient oriented research and to expand opportunities for mentoring within the Duke University. This protected time will allow Dr. Goode to continue to lead a productive research group and maintain minimal teaching and administrative responsibility at the Departmental and University levels. As part of this application Dr. Goode will advance his epidemiological and mechanistic expertise by combining these areas with incorporating real world data to understand the health care utilization along with the transition from acute to chronic low back pain. There are plentiful opportunities to expand the work Dr. Goode has begun, and extremely high potential for clinical break-through in this important area of clinical research.

项目摘要/摘要这是一份以患者为导向的职业生涯中期调查员奖的提交材料研究（K24）。申请人Adam Goode博士是杜克大学临床医生科学家兼副教授骨科。在他的整个职业生涯中，古德博士一直致力于流行病学和机制研究研究旨在更好地了解腰痛和肌肉骨骼疾病存在的异质性。这些研究使用在血清和尿液中发现的先进成像和生化生物标志物来表征疾病状态和进展。这些努力产生了当前的 R01 慢性腰痛机械生物标志物 (AR075399) 对椎间盘进行高级成像，以表征机械应变与腰痛和最近资助的 R01 半月板损伤后软骨健康的生物和生物力学预测因子（AR079184）。这些活动和项目吸引了广泛的多学科团队，致力于增进我们的理解以患者为导向的研究中的腰痛、脊柱和膝关节 OA。当前申请请求资金（50％工资支持）5年，以支持进行拟议的以患者为导向的研究所需的受保护时间，并扩大杜克大学内部的指导机会。这段受保护的时间将使古德博士能够继续领导一个富有成效的研究小组，并在院系和部门维持最低限度的教学和行政责任大学水平。作为该应用程序的一部分，古德博士将通过以下方式提高他的流行病学和机制专业知识：将这些领域与现实世界数据相结合，以了解医疗保健利用情况以及转型从急性到慢性腰痛。有很多机会可以扩展古德博士已经开始的工作，并且在这一重要的临床研究领域中具有极高的临床突破潜力。