The Effect of Pubertal Hormones on theDevelopment of Neural Oscillatory Dynamics in Youth

青春期激素对青少年神经振荡动力学发育的影响

• 批准号: 10605727
• 负责人: Abraham Killanin
• 金额: $ 4.16万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-13 至 2026-09-12
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10605727
• 关键词: Academic achievement; Address; Adolescence; Adolescent; Affect; Affective; Age; Animals; Anxiety; Area; Attention; Behavior; Behavioral; Brain; Brain Mapping; Child; Childhood; Chronology; Clinical Skills; Cognition; Cognitive; Data; Dendritic Spines; Development; Development Plans; Disease; Doctor of Philosophy; Emotional; Estradiol; Event; Fellowship; Female; Foundations; Future; Goals; Gonadal Hormones; Gonadal Steroid Hormones; Hair; Hormonal Change; Hormones; Hospitals; Human; Incidence; Individual; Insula of Reil; International; Journals; Knowledge; Laboratories; Life; Link; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Magnetoencephalography; Manuscripts; Measures; Medical center; Mental Depression; Mental disorders; Mentors; Methods; Minority; Nebraska; Neurophysiology - biologic function; Neurosecretory Systems; Parietal; Participant; Performance; Physicians; Plasma; Prevalence; Proxy; Psychiatry; Psychopathology; Puberty; Reaction Time; Recording of previous events; Research; Research Design; Research Support; Rodent Model; Role; Sampling; Scientist; Sex Differences; Short-Term Memory; Socioeconomic Status; Source; Structure; Sum; Symptoms; Testing; Testosterone; Training; Universities; Visuospatial; Work; Youth; age effect; base; boys; career; career development; cognitive development; cognitive enhancement; cognitive function; cognitive neuroscience; cognitive system; critical period; dehydroepiandrosterone; density; design; doctoral student; frontier; gray matter; imaging study; improved; male; memory process; neural circuit; neural network; neurodevelopment; neuroimaging; programs; puberty transition; reconstruction; relating to nervous system; research and development; selective attention; sex; statistics; symposium

Project Summary This application describes the research plan and program of study leading to a PhD as part of a combined MD- PhD Program at the University of Nebraska Medical Center and the Boys Town National Research Hospital. The central goal of this research plan is to identify how dehydroepiandrosterone (DHEA), testosterone, and estradiol modulate the development of cognitive systems serving selective attention and working memory processing. Briefly, the pubertal transition period is marked by significant increases in these hormones and substantial developmental advancements in higher-order cognitive functions, including working memory, selective attention, and others. However, on the other hand, the incidence of psychiatric disease also increases during puberty, and is accompanied by greater sex differences in disease prevalence. It has been suggested that this emergence of psychiatric illness during puberty might be associated with the drastic hormonal changes that mark this developmental stage, but the net impact of these hormonal changes on brain function and cognition is poorly understood. This F30 fellowship proposal will examine the sex and region-specific effects of DHEA, testosterone, and estradiol on working memory and selective attention processing using an advanced dynamic functional mapping approach based on magnetoencephalography (MEG), and includes a rigorous training and career development plan for a future physician-scientist in the areas of pediatric psychiatry and developmental cognitive neuro- science. The specific aims are (1) to examine the unique effects of pubertal hormones in predicting performance on selective attention and working memory tasks and (2) to identify the relationship between sex steroid hormone levels, neural oscillatory dynamics, and behavior during attention and working memory tasks. The trainee is a minority MD/PhD student in his 2nd year of PhD study who has already distinguished himself through two first- authored manuscripts in top journals, participation and presentation in scientific conferences, and a strong history of academic achievement. In sum, this application for an F30 fellowship will use MEG, advanced source reconstruction methods, neural oscillatory analyses, and hair-sampled hormone analysis to delineate the relationship between pubertal hormone levels, brain dynamics, and cognitive development. The program of study is designed to support this research plan through rigorous training by an internationally known expert in MEG and dynamic brain mapping who has a strong record of mentoring trainees, as well as an expert collaborator in pubertal hormone analysis and interpretation, with the primary goals of developing and expanding the research and clinical skills of the applicant to produce a physician-scientist who is well equipped and prepared for the next stage of his career.

项目概要 该申请描述了获得博士学位的研究计划和学习计划，作为联合医学博士- 内布拉斯加大学医学中心和男孩镇国家研究医院的博士项目。这 该研究计划的中心目标是确定脱氢表雄酮 (DHEA)、睾酮和雌二醇如何 调节服务于选择性注意和工作记忆处理的认知系统的发展。 简而言之，青春期过渡期的特点是这些激素显着增加，并且大量 高阶认知功能的发展进步，包括工作记忆、选择性注意力、 和其他人。但另一方面，青春期精神疾病的发病率也随之增加， 伴随着疾病患病率的更大性别差异。有人提出，这种现象的出现 青春期的精神疾病可能与荷尔蒙的剧烈变化有关 发育阶段，但这些荷尔蒙变化对大脑功能和认知的净影响很差 明白了。 这项 F30 奖学金提案将研究 DHEA、睾酮和 使用先进的动态功能映射研究雌二醇对工作记忆和选择性注意处理的影响 基于脑磁图 (MEG) 的方法，包括严格的培训和职业发展 为儿科精神病学和发育认知神经学领域的未来医师科学家制定计划 科学。具体目标是（1）检查青春期激素在预测表现方面的独特作用 关于选择性注意和工作记忆任务以及（2）确定性类固醇激素之间的关系 水平、神经振荡动力学以及注意力和工作记忆任务期间的行为。实习生是一位 少数族裔医学博士/博士生，正在进行博士研究的第二年，他已经通过两项第一- 在顶级期刊上撰写手稿，参加科学会议并发表演讲，以及悠久的历史 的学术成就。总之，此 F30 奖学金申请将使用 MEG、高级源 重建方法、神经振荡分析和头发采样激素分析来描绘 青春期激素水平、大脑动态和认知发展之间的关系。学习计划 旨在通过国际知名 MEG 专家的严格培训来支持该研究计划 和动态大脑图谱，他在指导学员方面拥有良好的记录，也是一位专家合作者 青春期激素分析和解释，主要目标是发展和扩大研究 申请人的临床技能，以培养出一位装备精良并为下一步做好准备的医师科学家 他职业生涯的阶段。