Developmental Research Program

发展研究计划

• 批准号: 9071068
• 负责人: James Brugarolas
• 金额: $ 16.85万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9071068
• 关键词: Antisense Oligonucleotides; Area; Augmented Reality; Award; Budgets; Cancer Center; Cancer Patient; Cancer Research Project; Clinical; Collaborations; Development; Dose; Eligibility Determination; Ensure; Evaluation; Fostering; Funding; Funding Agency; Goals; Grant; Human; Hypertension; IL2 gene; Immune; International; Leadership; Letters; Medical center; Mentors; Minority; Mission; Molecular; Mus; Nephrectomy; Operative Surgical Procedures; Outcome; Participant; Patients; Peer Review; Phase II Clinical Trials; Physicians; Preparation; Program Research Project Grants; Publications; Qualifying; Radiation; Raptors; Recruitment Activity; Renal carcinoma; Request for Applications; Research; Research Personnel; Resources; Robotics; Scientific Advances and Accomplishments; Scientist; Seeds; Selection Criteria; Signal Transduction; Source; Texas; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Woman; Work; anticancer research; biomarker identification; design; high risk; improved outcome; innovation; interest; meetings; multidisciplinary; programs; research study; response; success; synergism; tool; transcription factor; trend; tumor

Project Summary The Developmental Research Program (DRP) of the UTSW kidney cancer SPORE grant provides seed funding for promising translational projects that can significantly impact kidney cancer research. The DRP will fund pilot and/or high-impact/high-risk projects using innovative approaches, with the potential to generate groundbreaking discoveries, and a focus on translation. The DRP is led by Dr. Brugarolas, the SPORE Director, and Project 4 Co-Leader, Dr. Mendell. Their research is characterized by innovation and translation, two attributes sought in DRP projects. DRP proposals will be solicited via the Administrative Core; they will be prescreened for eligibility, suitability, and relevance by the DRP leadership; reviewed by two internal and one external expert; and approved for funding by the SPORE Executive Committee. As part of our mission to increase diversity, mechanisms are in place to recruit women and minorities. In addition to the $100,000/yr designated for the DRP through the SPORE grant, UTSW, via the Simmons Cancer Center, is committing an additional $100,000/yr for a total of $200,000 to fund DRP projects annually. The DRP will award 2-4 projects per year (a total of 15-20 projects over 5 years). Criteria for selection include: significance, innovation, approach, investigator qualifications, and translational potential (or synergism with existing projects). Priority will be given to projects with the potential to become full SPORE projects. The specific aims of the DRP are to: 1) Serve as a mechanism to provide seed funding for promising projects. 2) Identify and recruit a pool of promising scientists and physician-scientists. 3) Facilitate the development and progress of the DRP projects and the transition of successful projects into competitive applications for peer-reviewed funding. 4) Support SPORE DRP awardees to ensure that scientific advances are translated into improved outcomes for kidney cancer patients. DRP awardees will have full use of SPORE Core resources, will benefit from the expertise and leadership of the SPORE investigators (who may serve as mentors), and will be an integral part of SPORE meetings, where they will regularly present their work. Metrics of success for DRP recipients include: invitations to present at national and international scientific meetings; successful competition for independent NIH grant support (in particular R01 grants); publication of original research studies in the supported area; and, institutional recognition by promotion through the academic ranks. DRP projects that make significant progress towards their translational goals have the potential to be promoted to full SPORE projects. In response to a request for applications, 9 letters of intent were received including 4 that are showcased. A rich and diverse pipeline of research interests/expertise pertinent to kidney cancers at UTSW populates a dynamic DRP, expanding the breadth and depth of the SPORE/Kidney Cancer Program research.

项目摘要 UTSW肾脏癌孢子的发展研究计划（DRP）提供了种子 为有希望的翻译项目提供资金，这些项目可能会对肾脏癌研究产生重大影响。 DRP会 使用创新的方法进行基金飞行员和/或高风险/高风险项目，有可能产生 开创性的发现，重点是翻译。 DRP由孢子Brugarolas博士领导 董事和项目4联合领导者门德尔博士。他们的研究以创新和翻译为特征， DRP项目中寻求的两个属性。 DRP建议将通过行政核心征求；他们会的 DRP领导人的资格，适合性和相关性得到了预先筛选；由两个内部和一个审查 外部专家；并获得了孢子执行委员会的批准。作为我们任务的一部分 增加多样性，招募妇女和少数民族的机制。除了$ 100,000/年 通过西蒙斯癌症中心（Simmons Cancer Center 每年额外的100,000美元/年，总计200,000美元，每年为DRP项目提供资金。 DRP将授予2-4个项目 每年（在5年内总共有15-20个项目）。选择标准包括：意义，创新， 方法，研究者资格和翻译潜力（或现有项目的协同作用）。优先事项 将提供有可能成为全孢子项目的项目。 DRP的具体目的是： 1）作为为有前途的项目提供种子资金的机制。 2）识别并招募一个池 有前途的科学家和医师科学家。 3）促进DRP项目的发展和进步 以及成功的项目过渡到同行评审资金的竞争应用程序。 4）支持 孢子DRP获奖者，以确保将科学进步转化为肾脏的改善结果 癌症患者。 DRP获奖者将充分利用孢子核心资源，将从专业知识中受益， 孢子调查人员的领导（可以担任导师），并将成为孢子的组成部分 会议，他们将定期介绍自己的工作。 DRP接收者成功的指标包括： 邀请在国家和国际科学会议上举行；成功的独立竞争 NIH赠款支持（特别是R01赠款）；在受支持地区的原始研究发表；和， 通过学术界晋升的机构认可。 DRP项目取得了重大进展 实现他们的翻译目标有可能将其促进到完整的孢子项目。响应一个 申请请求，收到了9封意向书，其中包括4个展示的。富人多样 与UTSW的肾癌有关的研究兴趣/专业知识的管道填充了动态的DRP， 扩大孢子/肾癌计划研究的广度和深度。