A Study of Pulmonary Congestion and Patient-reported Outcomes in Heart Failure (MONITOR - HF)

心力衰竭肺充血和患者报告结果的研究 (MONITOR - HF)

• 批准号: 9190617
• 负责人: Jonathan Patrick Auld
• 金额: $ 4.36万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9190617
• 关键词: Address; Admission activity; Adult; Affect; Behavior; Behavioral; Biological; Biological Markers; Biology; Cardiac; Cardiopulmonary; Cardiovascular Diseases; Clinical; Clinical Management; Data; Defibrillators; Development; Devices; Diagnosis; Distress; Dyspnea; EFRAC; Edema; Elderly; Fatigue; Fellowship; Foundations; Frequencies; Functional disorder; Goals; Heart; Heart failure; Hospitalization; Hospitals; Implant; In Situ; Incidence; Influentials; Interdisciplinary Study; Intervention; Knowledge; Link; Lung; Measures; Mission; Modeling; Monitor; Morbidity - disease rate; National Institute of Nursing Research; National Research Service Awards; Nurses; Pacemakers; Patient Outcomes Assessments; Patients; Prevalence; Quality of life; Research Proposals; Research Training; Role; Scientist; Self Care; Self Management; Signs and Symptoms; Surveys; Symptoms; Technology; Testing; Time; Training; United States; Weight Gain; Work; base; behavior influence; clinically significant; cohort; experience; health related quality of life; heart function; hemodynamics; improved; improved outcome; innovation; insight; longitudinal design; mortality; physical symptom; pressure; prevent; programs; reduce symptoms; symptom management; symptom self management

Project Summary Heart failure (HF) is the fastest growing cardiovascular disorder in the United States and continues to be associated with high morbidity and mortality. Recognition of symptoms is a critical factor in the diagnosis and treatment of HF because symptoms are key drivers of hospitalizations and health-related quality of life (HRQOL). Our ability to predict who will experience more burdensome symptoms is hindered by the lack of association between objective markers of heart function and symptoms. A critical gap in our knowledge of HF symptom biology is how pulmonary congestion, an objective measure of HF pathophysiology, is related to HF symptoms, self-management behaviors and HRQOL. Accordingly, the overall goals of this study is to determine the association of pulmonary congestion that is detected by devices used in the clinical management of HF with physical symptoms of HF and HRQOL and to examine the role of self-management in moderating the relationship between device-detected congestion, symptoms and quality of life. Employing a longitudinal design and integrating data remotely downloaded from implanted defibrillator/pacemakers and data collected via survey in a cohort of 60 adults with symptomatic HF, we will address two specific aims: 1) quantify the association between device-detected congestion with both HF symptoms and HRQOL and 2) determine the influence of HF self-care management on the relationship between device-detected congestion and HF symptoms and HRQOL. This innovative study will be the first to examine associations between pulmonary congestion and physical HF symptoms and the first to determine the role of patient self-care management in moderating the relationship between device-detected congestion, HRQOL and symptoms of HF. Furthermore, as a research proposal supported by a National Research Service Award, this study will contribute to the development of the applicant into an independent nurse scientist with an influential program of study focusing on biological and behavioral foundations of HF symptoms. The proposed study and training plan integrate the combined clinical and analytic expertise of a well-established interdisciplinary team. This proposed fellowship research and training plan is well-aligned with the mission and goals of National Institute of Nursing Research through the focus on symptom biology, self-management behaviors, and the development of influential and independent nurse scientists.

项目摘要 心力衰竭（HF）是美国增长最快的心血管疾病，继续是 与高发病和死亡率有关。识别症状是诊断的关键因素 HF的治疗是因为症状是住院和与健康相关的生活质量的关键驱动因素 （HRQOL）。由于缺乏 心脏功能和症状的客观标记之间的关联。我们对HF的了解的关键差距 症状生物学是HF病理生理学的客观测量肺充血与HF有关 症状，自我管理行为和HRQOL。因此，这项研究的总体目标是 确定由临床中使用的设备检测到的肺部充血的关联 HF和HF和HRQOL的身体症状的管理，并检查自我管理的作用 调节设备发现的拥塞，症状和生活质量之间的关系。雇用 纵向设计和集成了从植入的除颤器/起搏器和 通过调查收集的60名有症状HF成年人的研究，我们将解决两个具体目标：1） 量化设备确定的拥塞与HF症状和HRQOL之间的关联，以及2） 确定HF自我护理管理对设备检测拥塞之间关系的影响 以及HF症状和HRQOL。这项创新的研究将是第一个研究关联的研究 肺部充血和身体HF症状，第一个确定患者自我护理的作用 管理设备发现的拥塞，HRQOL和症状之间的关系 HF。此外，作为由国家研究服务奖支持的研究建议，本研究将 通过有影响力的计划，将申请人发展成独立护士科学家 研究重点是HF症状的生物学和行为基础。拟议的研究和培训 计划整合了一个良好的跨学科团队的临床和分析专业知识。这 拟议的奖学金研究和培训计划与国家研究所的使命和目标齐全 通过关注症状生物学，自我管理行为和发展的护理研究 有影响力的独立护士科学家。