Mentoring and Research on Cognitive Deficits in Schizophrenia

精神分裂症认知缺陷的指导和研究

基本信息

批准号：
8957920
负责人：
DARA S MANOACH
金额：
$ 17万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-12-01 至 2017-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8957920
关键词：
Affect Animal Model Animals Attention Brain Chronic Clinic Clinical Cognition Cognitive Cognitive deficits Collaborations Contralateral Data Analyses Double-Blind Method Dreams Electroencephalography Environment Eszopiclone Evolution Failure Foundations Funding General Hospitals Generations Goals Health Human Impaired cognition Individual Investigation Laboratories Lead Learning Licensing Link Literature Magnetic Resonance Imaging Magnetoencephalography Massachusetts Mediating Memory Memory impairment Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methods Modeling Motor Motor Cortex National Institute of Mental Health Nature Neurosciences Parents Patients Pharmaceutical Preparations Physiology Pilot Projects Placebo Control Play Polysomnography Population Probability Process Psychiatry Psychologist Psychology Quality of life Research Research Personnel Research Support Research Training Role Schizophrenia Scientist Senior Scientist Sleep Sleep disturbances Solid Techniques Thalamic Nuclei Time Training Translating Translational Research Work base career cognitive function effective intervention effective therapy executive function functional outcomes hypnotic improved improved outcome mathematical model medical schools memory consolidation memory process mid-career faculty neuroimaging neuropsychiatric disorder neuroregulation novel marker patient oriented patient oriented research procedural memory programs receptor relating to nervous system skills spatiotemporal success therapy development translational study

Affect Animal Model Animals Attention Brain Chronic Clinic Clinical Cognition Cognitive Cognitive deficits Collaborations Contralateral Data Analyses Double-Blind Method Dreams Electroencephalography Environment Eszopiclone Evolution Failure Foundations Funding General Hospitals Generations Goals Health Human Impaired cognition Individual Investigation Laboratories Lead Learning Licensing Link Literature Magnetic Resonance Imaging Magnetoencephalography Massachusetts Mediating Memory Memory impairment Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methods Modeling Motor Motor Cortex National Institute of Mental Health Nature Neurosciences Parents Patients Pharmaceutical Preparations Physiology Pilot Projects Placebo Control Play Polysomnography Population Probability Process Psychiatry Psychologist Psychology Quality of life Research Research Personnel Research Support Research Training Role Schizophrenia Scientist Senior Scientist Sleep Sleep disturbances Solid Techniques Thalamic Nuclei Time Training Translating Translational Research Work base career cognitive function effective intervention effective therapy executive function functional outcomes hypnotic improved improved outcome mathematical model medical schools memory consolidation memory process mid-career faculty neuroimaging neuropsychiatric disorder neuroregulation novel marker patient oriented patient oriented research procedural memory programs receptor relating to nervous system skills spatiotemporal success therapy development translational study

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项目摘要

DESCRIPTION (provided by applicant): I am a licensed clinical neuropsychologist and a cognitive neuroscientist. I have devoted my career to understanding the neural basis and nature of fundamental cognitive deficits in neuropsychiatric disorders, primarily schizophrenia. I serve as a Psychologist and an Associate Professor of Psychology in the Department of Psychiatry at Massachusetts General Hospital (MGH) and Harvard Medical School. I also serve as the Director of the Laboratory for Multimodal Neuroimaging of Executive Function in the Division of Psychiatric Neuroimaging at MGH. I have been conducting NIMH sponsored patient oriented research (POR) continuously since the initiation of my K23 award in 1999. Since 2003, I have been the PI on an R01 entitled, Spatiotemporal dynamics of context processing in schizophrenia. The goal of this work is to identify the neural bases of fundamental cognitive deficits using complementary neuroimaging techniques. I am also the PI on the new parent R01 entitled, Sleep-Dependent Memory Processing in Schizophrenia, which will link a specific cognitive deficit (impaired memory consolidation) to a particular mechanism (abnormal sleep spindles) and provide an effective treatment (eszopiclone, which restored sleep spindles and memory in a placebo-controlled pilot study). More broadly, this research program has the potential to substantially expand current models of cognitive deficits in neuropsychiatric disorders and lead to effective interventions. I work in an incredibly rich environment for clinica research and have assembled a dream team of collaborators. I receive no institutional support for mentoring or research and without additional funding, I will have to curtail these activities t assume significant clinical responsibilities beginning in 2012. The K24 will protect time that would otherwise be diverted to clinical responsibilities and allow me to devote more time to providing intensive ongoing mentorship to junior investigators in POR (30%) and to further develop my expertise in the neuroscience and measurement of sleep via new training and research (20%) while continuing to devote 50% of my effort to conducting funded POR that translates advances in neuroscience into treatments for cognitive deficits.

描述（由申请人提供）：我是有执照的临床神经心理学家和认知神经科学家。我致力于理解神经精神疾病（主要是精神分裂症）的基本认知缺陷的神经基础和性质。我担任马萨诸塞州综合医院（MGH）和哈佛医学院精神病学系的心理学家和心理学副教授。我还担任MGH精神神经影像学部执行功能多模式神经影像学实验室主任。自从1999年启动我的K23奖以来，我一直在不断进行NIMH赞助的NIMH赞助患者研究（POR）。自2003年以来，我一直是精神分裂症上下文处理的R01的PI。这项工作的目的是使用互补的神经影像技术来确定基本认知缺陷的神经底座。我也是精神分裂症中题为“睡眠依赖性记忆处理”的新父r01的PI，它将将特定的认知缺陷（记忆巩固受损）与特定机制（异常睡眠纺锤体）联系起来，并提供有效的治疗方法（Eszopiclone（Eszopiclone）（Eszopiclone）（Eszopiclone）（Eszopiclone）（恢复了安慰剂训练的睡眠和记忆力）。更广泛地说，该研究计划有可能大大扩大神经精神疾病中认知缺陷的当前模型，并导致有效的干预措施。我在一个非常丰富的环境中为临床研究工作，并组建了一个梦想中的合作者团队。我没有获得指导或研究的机构支持，如果没有额外的资金，我将不得不限制这些活动，从2012年开始，我将承担重要的临床责任。K24将保护时间，这些时间将保护时间，这些时间将转移到临床责任中，并让我更多地花费更多的时间，使我能够为近期的培训（30％）的专业知识（30％）提供了持续的持续培训，并在培训中，并通过培训（30％），并以新的培训（30％），并获得了新的专业知识（30％），并在此方面获得了专业知识（30％）的专业知识，并将我将50％的努力用于进行资助的POR，将神经科学的进步转化为认知缺陷的治疗方法。