Shared Resource: Laboratory Animal Facility

共享资源：实验动物设施

基本信息

批准号：
9331464
负责人：
Hilton J. Klein
金额：
$ 17.27万
依托单位：
RESEARCH INST OF FOX CHASE CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9331464
关键词：
Abbreviations Accreditation Advisory Committees Animal Experimentation Animal Housing Animal Husbandry Animal Model Animal Welfare Animals Antibodies Award Bioinformatics Biological Biological Assay Biological Models Biometry Blood Cells Bone Marrow Transplantation Breeding Cancer Biology Cancer Center Cancer Center Support Grant Cancer Control Caring Cell Culture Techniques Cell Separation Cesarean section Communicable Diseases Comprehensive Cancer Center Consultations Data Collection Detection Development Doctor of Philosophy Embryo Transfer Ensure Enzymes Epigenetic Process Equipment Fox Chase Cancer Center Foxes Funding Genes Genetic Genomics Germ-Free Health Health Services Health Services Accessibility Health system Hematopoiesis Hematopoietic Histopathology Facility Image Immunocompetent Immunocompromised Host Immunology Impairment Infectious Agent Interleukin-6 International Interruption Investments Knowledge Laboratory Animal Shared Resource Laboratory Animals Leadership Link Malignant Neoplasms Mammals Medical Research Modeling Modification Molecular Molecular Models Mus NCI Center for Cancer Research Organism Oryctolagus cuniculus Parents Patients Peer Review Pharmaceutical Preparations Polymerase Chain Reaction Population Study Procedures Protocols documentation Rana Rattus Recommendation Reporting Research Research Personnel Resource Sharing Resources Risk Rodent Science Services Site Surveillance Program Therapeutic Tissue Banks Transgenic Mouse Facility Transgenic Organisms Travel Treatment Protocols United States Department of Agriculture Universities University Hospitals Xenograft procedure Zebrafish animal care animal facility cancer prevention cell type comparative cost cost effective cost efficient experience gene discovery guide for the care and use of laboratory animals high throughput screening in vivo laboratory facility medical schools member molecular modeling oncology pathogen peer support programs repository skills square foot

项目摘要

MODEL SYSTEMS SHARED RESOURCE: LABORATORY ANIMAL FACILITY (LAF) PROJECT SUMMARY/ABSTRACT The Laboratory Animal Facility (LAF) allows the creation and use of translational animal models to facilitate research for Cancer Center members. The animal care program at FCCC has been fully accredited by AAALAC International since 1969 and has been awarded Emeritus status. The LAF is in full compliance with regulatory agencies including the Drug Enforcement Administration, United States Department of Agriculture, and Office of Laboratory Animal Welfare. Under the direction of Hilton Klein, VMD and with the support of 16 LAF management and technical staff, the LAF provides animal husbandry and animal support services for Cancer Center members who require mice, rabbits, frogs or other rodents for their research. Under the direction of Jennifer Rhodes, PhD, and the support of a scientific technician, a new Zebrafish service line is now available to Cancer Center members. Zebrafish are an ideal model to discover genes that are essential for hematopoietic development in vivo. The spectrum of blood cell types and the genes known to regulate normal hematopoiesis are well conserved between zebrafish and mammals, suggesting that the regulatory mechanisms directing lineage specification and differentiation are similar across vertebrate species. 38 Cancer Center members used the LAF in 2014. 95% of the mouse cages occupied in 2014 supported the science of investigators with peer-reviewed funding. 100% of the use of zebrafish services was in support of peer-review funded investigators in 2014. For the period 2011-2014, the LAF was utilized by 55 Cancer Center members from all five Research Programs. A Comparative Medical Research Building was constructed during the last cycle at a cost of $14M. ARRA funds of $8M were matched with institutional investment of $6M. This new vivarium adjoins the existing LAF building and provides an additional 12,511 net square feet for animal housing and procedures. FCCC invested $765,783 in renovations and equipment to make zebrafish services available. An on-site, centralized LAF is cost efficient and critical to the peer-reviewed, funded research programs at FCCC. The research animals and animal care staff are readily available to investigators and modifications in breeding, husbandry, or treatment protocols can be readily accomplished reducing any delay or misinterpretation. Although an off-site commercial facility could conceivably supply and care for FCCC research animals, the inconvenience to the investigators in both travel and transporting animals to and from FCCC would be a serious impairment to research. The majority (90%) of the approved animal use protocols involve at least weekly, in some instances daily, observations, data, or tissue collections by the research staff. The LAF is advised by a dedicated Facility Advisory Committee (FAC) that meets at least annually. FAC recommendations are directed to a governing Facility Parent Oversight Committee (FPOC), which serves to ensure that the LAF continues to have the necessary resources to provide the highest quality services. The FPOC issues reports to senior leadership.

模型系统共享资源：实验动物设施 (LAF) 项目概要/摘要实验动物设施 (LAF) 允许创建和使用转化动物模型，以促进癌症中心成员的研究。 FCCC 的动物护理计划已获得以下机构的充分认可： AAALAC International 自 1969 年以来一直被授予荣誉称号。 LAF 完全符合监管机构包括缉毒局、美国农业部、和实验动物福利办公室。在VMD Hilton Klein的指导下并得到16位的支持 LAF管理和技术人员，LAF为以下动物提供畜牧业和动物支持服务需要小鼠、兔子、青蛙或其他啮齿动物进行研究的癌症中心成员。下在 Jennifer Rhodes 博士的指导和科学技术人员的支持下，一条新的斑马鱼服务线正在建立现在可供癌症中心会员使用。斑马鱼是发现重要基因的理想模型用于体内造血发育。血细胞类型的范围和已知调节的基因斑马鱼和哺乳动物之间的正常造血功能得到了很好的保存，这表明调节脊椎动物物种中指导谱系规范和分化的机制是相似的。 38 癌症中心成员在 2014 年使用了 LAF。2014 年占用的小鼠笼中 95% 支持具有同行评审资金的研究人员科学。斑马鱼服务 100% 的使用是为了支持 2014 年同行评审资助的研究人员。2011-2014 年期间，55 名癌症患者使用了 LAF 中心成员来自所有五个研究项目。比较医学研究大楼落成在上一个周期中，成本为 1400 万美元。 800 万美元的 ARRA 资金与 600 万美元的机构投资相匹配。这个新的动物园毗邻现有的 LAF 大楼，并提供额外的 12,511 净平方英尺动物圈舍和程序。 FCCC 投资 765,783 美元用于翻新和设备生产斑马鱼可用的服务。现场集中式 LAF 具有成本效益，对于同行评审、资助的项目至关重要 FCCC 的研究项目。研究人员可以随时联系研究动物和动物护理人员并且可以很容易地完成育种、饲养或治疗方案的修改，从而减少任何延误或误解。尽管场外的商业设施可以想象供应和照顾 FCCC 研究动物，研究人员在旅行和运输动物方面的不便 FCCC 的影响将严重损害研究。大多数（90%）批准的动物用途方案至少每周，在某些情况下每天，由研究人员进行观察、数据或组织收集。研究人员。 LAF 由专门的设施咨询委员会 (FAC) 提供建议，该委员会至少召开会议每年。 FAC 建议直接提交给管理机构家长监督委员会 (FPOC)，这有助于确保 LAF 继续拥有必要的资源来提供最高质量的服务服务。 FPOC 向高级领导层发布报告。